NAVIFY Decision Support Portfolio Decision support software with

NAVIFY Decision Support Portfolio Decision support software with 120 years of medical innovation rooted in science 1

Increasing medical complexities demand new tools and approaches that enable personalised healthcare Complexity Disease Research has identified ~1. 2 million mutations from more than 20 tumour types 1 Diagnosis An estimated 60%-70% of decision-making in healthcare is influenced by diagnostic testing 2 Treatment >500 pharmaceutical treatments exist for cancer and conditions related to cancer 3 Workflow Patient information resides in disparate sources and formats across specialty teams Need New research and development approaches Comprehensive diagnostics are essential to personalised care Better awareness of and access to myriad treatment options More streamlined and efficient clinical workflow Cell. “Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns to Shape the Cancer Genome. ” November 2013. https: //www. ncbi. nlm. nih. gov/pmc/articles/PMC 3891052/#R 3 (accessed November 13, 2018) 2 National Academies of Sciences, Engineering, and Medicine. 2018. Improving Cancer Diagnosis and Care: Patient Access to Oncologic Imaging and Pathology Expertise and Technologies: Proceedings of a Workshop. Washington, DC: The National Academies Press. https: //doi. org/10. 17226/25163 (accessed November 7, 2018) 3 National Institutes of Health National Cancer Institute. “A to Z List of Cancer Drugs. ” https: //www. cancer. gov/about-cancer/treatment/drugs? redirect=true (accessed October 18, 2018) 1 2

Present Improved data Looking at the disease and the patient at the same time 3

Future Individualised treatment NAVIFY Portfolio use all relevant available medical data to personalise healthcare Targeted therapy Genomic profile Real-world data Evidenced-based data 4

NAVIFY Decision Supportfolio Clinical and scientific actionable insights drive personalised healthcare Electronic Medical Records Diagnostics (LIS) Molecular data Imaging (PACS) NAVIFY Portfolio Clinical trials Publications Digital pathology 5

NAVIFY Decision Supportfolio Modular. Extendable. Scalable. Value-Added services NAVIFY Clinical Decision Support apps Publicatio n Search* Roche and GE NAVIFY apps NAVIFY Tumor Board Partn er apps NAVIFY Workflow solution NAVIFY platform Security Privacy Available now Thirdparty apps In development Analytics NAVIFY Workflow products Clinical Trial Match* NAVIFY Clinical Decision Support apps • Fully integrate with NAVIFY workflow products • Provide timely and relevant, patient-specific, actionable insights to treatment decisions • Present additional treatment and research information NAVIFY Workflow products • Streamline workflow • Increase collaboration • Standardise processes NAVIFY platform • Provides secure infrastructure • Facilitates data management • Offers unified core services to power multiple solutions *Powered by Molecular. Match, Inc. 6

NAVIFY Tumor Board 7

NAVIFY Tumor Board NAVIFY Clinical Decision Support apps The clinical decision support apps ecosystem is secured and fully integrated with NAVIFY Tumor Board. NAVIFY Clinical Trial Match app* Easily search the largest international trial registries, including Clinical. Trials. gov, European Medicines Agency and private institutions NAVIFY Publication Search app* A cloud-based workflow product that securely integrates and displays relevant aggregated data into a single, holistic patient dashboard for oncology care teams to review, align and decide Effortlessly search more than 300, 000 publications across Pub. Med, American Society of Clinical Oncology and American Association of Cancer Research. on the optimal treatment for the patient. *Powered by Molecular. Match, Inc. 8

NAVIFY Tumor Board Benefits that improve MDT effectiveness and relevance Collaboration among specialists Increased workflow efficiency Comprehensive patient overview NAVIFY Tumor Board could shorten MDT preparation time for oncologists by as much as 53 percent. 1 MDT decision follow-up Standardisation across MDT Patient data security *Improved workflow efficiency with shorter tumor board preparation time for oncologists (-53%), radiologists (-12%) and surgeons (-8%). 1 Journal of Pathology Informatics. “A new software platform to improve multi-disciplinary tumor board workflows and user satisfaction: A pilot study. ” July 2018. 9

NAVIFY Clinical Trial Match app* Publication Search app* • All in one place • Current information in real-time • Unbiased results • Trusted, curated databases • Search in real-time • Integrated functionality • Current Information • All in one place • Patient-specific searches based on • Patient-specific results based on • Age • Stage • Gender • Genomic alterations • Biomarkers • Tumour location • Tumour information Results typically returned in seconds ** | Results can be filtered and pinned into NAVIFY Tumor Board patient presentations *Powered by Molecular. Match, Inc. ** Depends speeds on connection 10

NAVIFY Clinical Decision Support apps ecosystem Application Program Interface (API) NAVIFY Clinical Decision Support apps NAVIFY Clinical Trial Match app* NAVIFY Publication Search app* More NAVIFY apps Fully integrated with NAVIFY Tumor Partner apps Partner app 1 Partner app 2 Board, these apps deliver intelligent information and options for each patient in one place within the MDT. Software Development Kit (SDK) Thirdparty apps Available now TBD In development *Powered by Molecular. Match, Inc. 11

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