Mitochondrial DNA mt DNA How it is inherited

Mitochondrial DNA (mt. DNA) * How it is inherited? * How it is used in science? * Practice problems

Inheritance of DNA: * Mitochondrial DNA is only inherited from mother to child 100% from the mother * Nuclear DNA is inherited from both parents 50% from each parent

How mt. DNA is used? To identify unrecognizable human remains plane crash murder (Wm. Pickton) MIA soldiers World Trade Center disaster To identify maternity of adopted or missing children Chilean dictator Pinochet's death squads created many orphans who were reunited with family members via U of A assistance mass grave idents in Rwanda & Bosnia

How mt. DNA is used? mt. DNA has been used to assess the ancestry of all races, identify their origins & identify relationships among our species

Mitochondrial DNA Disease: Mutations may exist on mt. DNA which pass from mother to child Mutations the father may have inherited would never pass to offspring

Problems involving mt. DNA: 1) A loved ones remains have possibly been located in a field. Explain how each of the following relatives can be of use to help connect the remains with their genetic relatives via blood samples: a) victim's siblings e) victim's father b) victim's mother f) victim's father's siblings c) victim's mother's siblings g) victim's children d) victim's uncles 2) A paternity suit has been launched to determine the father. Can mt. DNA be used to determine the father of this child? Explain.

Diploma Q involving mt. DNA & Gender based inheritance: 1) Male Mussels of the genus Mytilus inherit their mitochondrial DNA (mt. DNA) from both their mother and father. The inheritance of mt. DNA in humans differs from that in male Mytilus mussels because human mt. DNA is A. identical to the mother's nuclear DNA B. transmitted from the father to all offspring C. transmitted from the mother to all offspring D. a mixture of the father's mt. DNA and nuclear DNA 2) Some men have a defect of the Y chromosome called an AZFc deletion, which results in low sperm production. Intracytoplasmic sperm injection (ICSI) is a reproductive technology that enables men with this genetic defect to father children. In ICSI, a sperm is injected directly into an egg. Men who have the AZFc deletion and who father children the ICSI procedure will pass on the infertility trait to A. their sons only C. their daughters only B. all their children D. none of their children through