Zalypsis has in vitro activity in acute myeloid

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Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through

Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response by Enrique Colado, Teresa Paíno, Patricia Maiso, Enrique M. Ocio, Xi Chen, Stela Álvarez-Fernández, Norma C. Gutiérrez, Jesús Martín-Sánchez, Juan Flores. Montero, Laura San Segundo, Mercedes Garayoa, Diego Fernández-Lázaro, Maria. Belen Vidriales, Carlos M. Galmarini, Pablo Avilés, Carmen Cuevas, Atanasio Pandiella, and Jesús F. San-Miguel haematol Volume 96(5): 687 -695 April 29, 2011 © 2011 by Ferrata Storti Foundation

Baseline characteristics of the AML patients’ samples. Enrique Colado et al. Haematologica 2011; 96:

Baseline characteristics of the AML patients’ samples. Enrique Colado et al. Haematologica 2011; 96: 687 -695 © 2011 by Ferrata Storti Foundation

Effect of zalypsis on the proliferation of acute myeloid leukemia (AML) cells. Enrique Colado

Effect of zalypsis on the proliferation of acute myeloid leukemia (AML) cells. Enrique Colado et al. Haematologica 2011; 96: 687 -695 © 2011 by Ferrata Storti Foundation

Zalypsis causes apoptotic cell death in acute myeloid leukemia cell lines. Enrique Colado et

Zalypsis causes apoptotic cell death in acute myeloid leukemia cell lines. Enrique Colado et al. Haematologica 2011; 96: 687 -695 © 2011 by Ferrata Storti Foundation

Zalypsis causes cell death through caspase-independent mechanisms. Enrique Colado et al. Haematologica 2011; 96:

Zalypsis causes cell death through caspase-independent mechanisms. Enrique Colado et al. Haematologica 2011; 96: 687 -695 © 2011 by Ferrata Storti Foundation

Zalypsis stimulates a DNA damage response through the induction of double-strand breaks. Enrique Colado

Zalypsis stimulates a DNA damage response through the induction of double-strand breaks. Enrique Colado et al. Haematologica 2011; 96: 687 -695 © 2011 by Ferrata Storti Foundation

Genes involved in the DNA damage pathway deregulated by zalypsis in HEL and HL

Genes involved in the DNA damage pathway deregulated by zalypsis in HEL and HL 60 cell lines. Enrique Colado et al. Haematologica 2011; 96: 687 -695 © 2011 by Ferrata Storti Foundation

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