YERSINIAE Yersinia Morphology Important species Pathogenesis Disease caused

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YERSINIAE

YERSINIAE

Yersinia • • Morphology Important species Pathogenesis Disease caused

Yersinia • • Morphology Important species Pathogenesis Disease caused

Y. pestis - Morphology • Gram negative • Plump/ovoid • Bipolar staining/ Safety pin

Y. pestis - Morphology • Gram negative • Plump/ovoid • Bipolar staining/ Safety pin appearance • Pleomorphic

Pathogenesis Highly complex antigenic structure No serotypes 20 antigens Fraction I, V and W

Pathogenesis Highly complex antigenic structure No serotypes 20 antigens Fraction I, V and W antigens, Pesticin, Coagulase, Fibrinolysin • Plague toxin- endotoxin and murine toxin = inhibit phagocytosis and intracellular killing of bacteria. • •

PLAGUE Ancient disease Himalayas/ Central Asia Epidemics/ pandemics Black death 14 th century -

PLAGUE Ancient disease Himalayas/ Central Asia Epidemics/ pandemics Black death 14 th century - killed a quarter of humans on earth • 18 and 19 th century- less • • •

Plague Last pandemic- Hong Kong, 1894 India worst hit 1896 - 1918 – 10

Plague Last pandemic- Hong Kong, 1894 India worst hit 1896 - 1918 – 10 million deaths Lessened , 1967 - 94 – no cases August 1994 - outbreak in Beed dist of Maharashtra • September 1994 – Surat, Gujarat • 6000 cases , 60 deaths • 2002 – Simla, 4 deaths • • •

Plague • Foci in India – Kolar, Beed – Latur, Rhoru, Uttaranchal • Types

Plague • Foci in India – Kolar, Beed – Latur, Rhoru, Uttaranchal • Types : Bubonic, Pneumonic, Septecemic • Spread/ Transmission : Flea bite, Droplet • No human carriers

Plague - A zoonosis • Rodents • Rat flea: Xenopsylla cheopis • Urban cycle

Plague - A zoonosis • Rodents • Rat flea: Xenopsylla cheopis • Urban cycle • Domestic cycle

Diagnosis • Specimens • Methods : Gram stain, Wayson stain, Fluorescent stain, Culture: NA,

Diagnosis • Specimens • Methods : Gram stain, Wayson stain, Fluorescent stain, Culture: NA, BA, MA, CA Non lactose fermenting colonies on MA Identified by biochemical tests Animal inoculation Serology PCR

Disposal , Prophylaxis, Treatment • 0. 5% phenol for 15 min • Carcasses –

Disposal , Prophylaxis, Treatment • 0. 5% phenol for 15 min • Carcasses – 3% lysol • Killed vaccine • Streptomycin, Doxycycline

Other Yersinia • Y. enterocolitica – Gastroenteritis, Mesenteric adenitis, Bacteremia • Y. pseudotuberculosis -

Other Yersinia • Y. enterocolitica – Gastroenteritis, Mesenteric adenitis, Bacteremia • Y. pseudotuberculosis - infections in rodents only

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Thank you

PATHOGENIC YERSINIAE CATEGORY PATHOGENS DISEASE Pathogenic Yersiniae DianePATHOGENIC YERSINIAE CATEGORY PATHOGENS DISEASE Pathogenic Yersiniae Diane
Yersinia Dr Salma Yersinia pestis Black death taxonomyYersinia Dr Salma Yersinia pestis Black death taxonomy
Yersinia Genre Yersinia Famille des Enterobacteriaceae Les espcesYersinia Genre Yersinia Famille des Enterobacteriaceae Les espces
YERSINIA PASTEURELLA GENUS YERSINIA Short gram negative bacilliYERSINIA PASTEURELLA GENUS YERSINIA Short gram negative bacilli
Yersinia Pestis Yersinia Y pestis Y pseudoctuberculosis YYersinia Pestis Yersinia Y pestis Y pseudoctuberculosis Y
Yersinia Pasteurella Francisella INTRODUCTION v The name YersiniaYersinia Pasteurella Francisella INTRODUCTION v The name Yersinia
an infectious disease caused by the bacteria Yersiniaan infectious disease caused by the bacteria Yersinia
Same species Same species Same species Same speciesSame species Same species Same species Same species
MORPHOLOGY THE STRUCTURE OF WORDS MORPHOLOGY Morphology dealsMORPHOLOGY THE STRUCTURE OF WORDS MORPHOLOGY Morphology deals
MORPHOLOGY LINGUISTICS WHATS MORPHOLOGY a Morphology is theMORPHOLOGY LINGUISTICS WHATS MORPHOLOGY a Morphology is the
Morphology NLP Morphology Morphology is the branch ofMorphology NLP Morphology Morphology is the branch of
III MORPHOLOGY III Morphology 1 Morphology The studyIII MORPHOLOGY III Morphology 1 Morphology The study