XCEDE Use Cases 2008 m BIRN AHM San

XCEDE Use Cases 2008 m. BIRN AHM San Juan, Puerto Rico

Overview • Users: • MR Therapy (MRT) Retrospective Data • • Neuro, Prostate • CVRG • IGT Ongoing Work • PNL Needs Discussion

MR Therapy Retrospective • Over 1000 Slicer-Guided Open MR Craniotomies • Large Subset (~200) Cases Collated with Preand Intra-Operative Images • • Various acq. , 1. 5 T and 0. 5 T • GE or NRRD format (not DICOM) National Center for Image Guided Therapy (Jolesz, BWH) Goal to Share the Data • Talos, Archip, and Haker Working with Marcus et al for Upload to XNAT Central • Prostate Brachitherapy Data Also Available for Upload

Psychiatry Neuroimaging Lab (PNL) • PNL (Shenton, Kubicki, Boiux BWH/VA) Schizophrenia Research • Structural Imaging, DTI, f. MRI • Demographics, Protocols, Clinical Assessments • • Label Maps, Activation Maps Currently Using Ad Hoc Methods • Shared Network Drive, Access Database, Spreadsheets… • Reluctant to Change if Database Administrator is Required • Would Greatly Benefit from Informatics Infrastructure If Easy To Use

CVRG • Cardiovascular Research Grid (Winslow, JHU) • Broad Range of Potential inputs: CT, MR, EKG, Pet, DWI… • Initial Three Cases of CT Torso Cases Uploaded to XNAT Central • Data from Drs. Triedman and Jolley, Boston Childrens Pediatric Cardiology • • Includes Detailed Heart Segmentation JHU Canine Heart DTI

Ongoing Image Guided Therapy Use • Collect Pre-Therapy Imaging • Run Diverse Analysis Routines • • Evolving Research Code • Multiple Investigators Bring Patient Maps into Real Time Navigation / Robotic System • Feed Procedure Images and Data Back to Database

Scenario 1: Manual Per-Subject Target Clinical Study Scenario: 1. Search XNAT or HID for Target Data 2. Receive. xcat File of Result URIs 3. Slicer 3 Retrieves Data and Metadata 4. Analysis, Visualization, Annotation 5. New Data and Provenance is Uploaded and Linked to Original Data

Scenario 2: Population Analysis Target Clinical Study Scenario: 1. Search XNAT or HID Target Population 2. Receive. xcat File of Result URIs 3. Search or Load Parameter Files for Tools 4. Dispatch Analysis for Remote Processing 5. Results are Uploaded to Database from Remote Analysis Machines

Scenario 3: Population Statistics Target Clinical Study Scenario: 1. Search XNAT or HID Processed Studies 2. Receive. xcat File of Result URIs 3. Specify Group Statistics Parameters 4. Dispatch Analysis for Remote Processing 5. Summary Results are Uploaded to Database from Remote Analysis Machines 6. Parametric Maps Downloaded to Local Tool for Interpretation

Requirements • Easy To Install XCEDE Compliant Server • • • XNAT Desktop? Web Services API • The Simpler the Better • Several Examples are Available • Digital. Bucket • Gene. Network Server-to-Server Data Migration • Automatic Synchronization? • cvs/svn-like checkouts and commits?