Why is Photostability Important 1 Biggest Innovation in

Why is Photostability Important? 1

Biggest Innovation in UVA Protection has Been the Invention of Avobenzone • Avobenzone provides broad spectrum beyond 370 nm 2. 5 With avobenzone Absorbance 2 1. 5 1 With oxybenzone 0. 5 0 290 310 330 350 370 390 Wavelength (nm) Data on file, Johnson & Johnson Neutrogena. 2

An Example of Avobenzone Photoinstability in a Sunscreen Formulation 2. 0 1. 8 Absorbance 1. 6 1. 4 1. 2 Static SPF 1. 0 10 J 0. 8 20 J 0. 6 50 J 0. 4 0. 2 0 290 310 330 350 370 390 Wavelength (nm) Data on file, Johnson & Johnson Neutrogena. 3

Why is Photostability Important? Photostable and non-photostable spf products have the same protection up to their SPF value, but protection after first MED is very different 4

How Can You Tell Which Ones Are Photostable? • Currently, there is no uniform test method or communication device on products to indicate photostability of products or extent of UVA protection 5

™ Helioplex Technology 6

What Comprises Helioplex™ Technology? • Photostable UVA – Contains avobenzone—provides broad UVA protection – Contains diethylhexyl 2, 6 -naphthalate (DEHN)— an avobenzone stabilizer – Contains benzophenone (oxybenzone, sulisobenzone, or dioxybenzone)—stabilizes avobenzone and adds UVA protection • Added SPF drivers – Conventional UV filters to build SPF Data on file, Johnson & Johnson Neutrogena. 7

Mechanism of Action of Helioplex™ UV UV 8

Mechanism of Action of Helioplex™ UV UV DEHN DEHN 9

Ultraviolet Photography demonstrates the red fluorescence of Helioplex® Photograph courtesy of Darrell Rigel, MD 10

Neutrogena Now Offers Broad-Spectrum Protection That Is Photostable Absorbance Neutrogena Ultra Sheer SPF 50+ With Helioplex™ Nonphotostable Sunscreen 1. 8 1. 6 1. 4 1. 2 1. 0 0. 8 30 J 0. 6 50 J 0. 4 0. 2 0 290 0 J 10 J 20 J 0 310 330 350 370 390 290 310 330 350 370 390 Wavelength (nm) Data on file, Johnson & Johnson Neutrogena. 11

Photostable in Real Sunlight Neutrogena Ultra Sheer SPF 50+ holds up under sunlight 2. 0 Absorbance 1. 5 Baseline 1. 5 hours of sun 1. 0 0. 5 0 290 310 330 350 370 390 Wavelength (nm) Data on file, Johnson & Johnson Neutrogena. 12

Photostable in Real Sunlight 2 1. 8 Neutrogena Ultra Sheer SPF 50+: PFA 12. 1 Absorbance 1. 6 1. 4 20% Zn. O SPF 4: PFA 4 1. 2 1 9% Ti. O 2 SPF 30: PFA 4. 5 0. 8 0. 6 0. 4 0. 2 0 290 310 330 350 370 390 Wavelength (nm) Data on file, Johnson & Johnson Neutrogena. 13

Photostability of Helioplex™ Compared With Anthelios SPF 60+ With Mexoryl® In Vitro Photostability (COLIPA Method) % Loss After 50 J Simulated Exposure % Loss 0 – 15% – 39% 20 COLIPA n = 5 avg 40 Neutrogena Ultra Sheer SPF 50+ With Helioplex™ Data on file, Johnson & Johnson Neutrogena. Anthelios XL 60+ 14

Photostable Even Under Direct Tropical Sun Exposure* 15

Helioplex™ technology offers a step change in protection • Helioplex™ technology offers exceptional and photostable UVA protection – PA +++! – PFA protection values for Helioplex products exceed 20 (PA+++ only requires PFA = 8) • Comparable protection to Mexoryl Anthelios XL 60 technology with better photostability 16

PLE Protection by Ultra Sheer SPF 50+ With Helioplex™: Results 17

PLE Protection by Ultra Sheer SPF 50+ With Helioplex™: Conclusions Subject Self-Perception Efficacy and Aesthetics Overall rating (excellent-good) Is gentle Does not sting Absorbs quickly/evenly Is not greasy/oily/tacky Weightless feeling Lengthens time outdoors 75 80 85 90 95 100 Percent Agreement Leyden J, et al. Multi-center evaluation of protective benefits of a photostable UVA/UVB sunscreen for polymorphic light eruption. Poster presentation at: American Academy of Dermatology 64 th Annual Meeting; March 3 -7, 2006; San Francisco, Calif. 18

PLE Protection by Ultra Sheer SPF 50+ With Helioplex™: Conclusions • Complete inhibition of PLE by Ultra Sheer SPF 50+ with Helioplex™ • The aesthetics of Ultra Sheer SPF 50+ with Helioplex™ was favorably rated by users with PLE; this may enhance compliance with use Leyden J, et al. Multi-center evaluation of protective benefits of a photostable UVA/UVB sunscreen for polymorphic light eruption. Poster presentation at: American Academy of Dermatology 64 th Annual Meeting; March 3 -7, 2006; San Francisco, Calif. 19

Neutrogena Helioplex Sunscreens • • • Does not leave a film/residue Is not tacky Is not sticky Is not greasy Leaves a velvety skin feel Leaves the skin feeling nourished Data on file, Johnson & Johnson Neutrogena. 20

Sunscreen With Helioplex™: Ultra Sheer Aesthetics • • Unsurpassed Protection Superior Aesthetics and Skinfeel Outstanding Value Dermatologists Preferred for themselves and their families 21