WHICAP Washington HeightsHamilton Heights Inwood Columbia Aging Project
WHICAP Washington Heights/Hamilton Heights. Inwood Columbia Aging Project Jennifer J. Manly, Ph. D Laura B. Zahodne, Ph. D
Acknowledgements • Funded in part by Grant R 13 AG 030995 -01 A 1 from the National Institute on Aging • The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U. S. Government.
Collaborators Maria Glymour Christopher Weiss Sze “Sam” Liu Adam Brickman Karen Siedlecki Laura Zahodne Danurys Sanchez Yaakov Stern Richard Mayeux Nicole Schupf Supported by • NIA R 01 AG 16206 (PI: Manly) • NIA P 01 AG 07232 (PI: Mayeux)
od o w Ham n ilto gh Hei H ts h g ei • • • PI: Richard Mayeux N > 6, 500 older adults Age 65 and older Spanish or English speaking Seen in home at 18 – 24 month intervals Dementia dx based on neuropsychological test battery, medical & functional interview Percent of sample n gto in sh a W WHICAP ts In
Annual age-specific incidence Age-Specific Incidence of Alzheimer’s Disease Tang et al. , 2001; Neurology 56: 49 -56
Recruitment across 3 Consensus cohorts diagnosis of • Inclusion/exclusion criteria • 1992: focus on prevalence in residents as is • 1999: focus on incidence in equal N ethnic groups, exclude for selfreported dementia diagnosis or serious memory complaints • 2009: + capacity to consent and willingness to give blood • Recruitment method • 1992/1999: Medicare lists • 2009: Relevate consumer data • Neighborhood • 65. 5% reduction in crime 1993 to 2007 dementia at baseline
N and availability of measures Visit 1 1992 2337 (1773) … 2 3 4 5 6 7 8 9 367 1531 1187 946 605 485 338 227 122 2174 1575 1173 780 459 318 2091 1032 386 1999 2009 Neuropsych upon positive dementia screen Neuropsych as part of core visits CESD Color Trails Education and literacy questions PSES, Sleep Structural MRI
Cognition Siedlecki 2008 2 = 1022. 27 RMSEA =. 04 CFI =. 93
Childhood health variables • Adult height • Tibia Length
Childhood SES variables • Mother’s grade/credential • Father’s grade/credential • Mother’s occupation at age 16 • Father’s occupation at age 16 • Country and state of birth • Rural versus urban • Year of immigration • Number of siblings • Early death of parent
Education variables • Years of education • State of elementary & HS education • Historical quality variables • Private vs. public • Rural vs. urban setting • Racial/ethnic breakdown of schools • Size (one room school vs. multi-room)
Reading Level English Spanish Wide Range Achievement Test reading subtest Word Accentuation Test I V Z J Q see red milk was between cliff stalk grunt clarify residenceurge rancid conspiracy deny quarantine deteriorate regime beatify internecine regicidal puerile factitious lucubration epithalamion inefficacious synecdoche ACULLA ABOGACIA ANOMALO CELIBE ALELI RABI APATRIDA HUSAR LEGORIA MANCHU DIAMETRO MOARE CONCAVO AMBAR PUGIL POLIGAMO ACME SILICE GRISU ALBEDRIO CANON PIFANO TACTIL VOLATIL DESCORTES DISCOLO BULGARO BALADI ACOLITO CUPULA Del Ser et al. , 1997 Identificacion de letras y palabras de la es uno por niño ciudad página vertical zaramugullón medicoquirúrgico corpóreo
Adult SES variables • Years of education • Joint monthly income • Occupation during most of life • Own or rent home • (Neighborhood)
Adult health variables • Self-reported medical diagnoses • Hypertension • Diabetes • Heart disease • Stroke • Medication categories • Head injury history • Blood pressure • Height, weight, BMI • Lipids, HBA 1 C, Cpeptide, (glucose)
Adult health behavior variables • Smoking • Alcohol • Exercise questionnaire • Leisure activities questionnaire
Adult psychosocial variables • Marital status • Living status • DSM depression checklist • CES-D
Genetic variables • APOE genotype • GWAS
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