WHAT IS VITAMIN D Vitamin D is classified

WHAT IS VITAMIN D? Vitamin D is classified as a fat soluble vitamin There are two important groups of this compound in humans: v Vitamin D 2 (Ergocalciferol) v Vitamin D 3 (Cholecalciferol) Pure Science. Innovative Thinking. Unparalleled Quality 1

Uses of Vitamin D • Regulates calcium uptake: Liver converts cholecalciferol into calcidiol kidney converts calcidiol to calcitriol Transported to intestinal tract, triggering the production of Calcium uptake proteins. • Suppresses abnormal cell growth • Stimulates immunity and prevents the development of autoimmune diseases. • Regulates the release of renin; citing its role in the cardiovascular system Pure Science. Innovative Thinking. Unparalleled Quality 2

Deficiency of vitamin D Prevalence of vitamin D deficiency is 30 -50% in the general population. Following disorders are the consequences resulting from this deficiency: • Osteoporosis and other bone abnormalities • Hip and vertebral fractures • Hypertension • Congestive heart failure • Autoimmune diseases • Chronic muscle aches Pure Science. Innovative Thinking. Unparalleled Quality 3

Diagnostic values Serum concentration of 25(OH)D 3 are used as diagnostic markers for Vitamin D • Normal levels are 30 -60 ng/ml • Concentrations < 12 -20 ng/ml are considered deficient • Levels > 60 ng/ml are considered toxic to the body. Recommended daily intake of vitamin D is 600 -800 IU Remember that 100 IU = 1 ng/ml Pure Science. Innovative Thinking. Unparalleled Quality 4

Sources of Vitamin D Food source: Very little food contains adequate amounts of vitamin D. The flesh of certain fatty fish ( salmon, tuna) and cod liver oil is a good source. Small amounts are also found in cheese , beef liver and egg yolks. Sun Exposure: Exposure to sunlight manufactures Vitamin D 3 through our skin, that’s why this vitamin is also known as the “sunshine vitamin”. Dietary supplements: Dietary supplements come in both forms of vitamin D. Research has shown D 2 to have lesser potency and short duration of action, rendering it half as effective as D 3 Pure Science. Innovative Thinking. Unparalleled Quality 5

Introducing…D-Sorb™ A wide range of vitamin D-3 potencies using the patented VESIsorb® colloidal droplet technology Pure Science. Innovative Thinking. Unparalleled Quality 6

D-Sorb™ in both Liquid Droplets and Solid Dosage Forms • Droplets A) 500 IU Vit. D*/drop (1 drop = 25 mg) B) 2'000 IU Vit. D*/drop (1 drop = 25 mg) *as D 3 plus Pre-D 3 • Available in various potencies from 500 IU to 15, 000 IU of D-3 per capsule and capsule sizes and D-3 potency can be customized Pure Science. Innovative Thinking. Unparalleled Quality 7

Vitamin D Bioavailability & VESIsorb (I) • Enhanced solubilization of Vitamin D 3 by VESIsorb®. . . ”Body Ready”. . . Vitamin D 3, like Coenzyme Q 10, is a poorly water-soluble compound. Thus, enhanced solubilization of Vitamin D 3 within the GI fluid by VESIsorb® may improve its oral bioavailability. • Fat/food independent absorption The absorption of Vitamin D 3, like the one of other poorly water-soluble vitamins, is dependent on food respectively fat. Like other solubilizing delivery system VESIsorb can reduce this food/fat effects and hence may provide more reproducible Vitamin D 3 plasma levels. Pure Science. Innovative Thinking. Unparalleled Quality 8

Vitamin D Bioavailability & VESIsorb (II) • MCT Vitamin D 3 dissolved in medium-chain triglycerides (MCT) produced a 4. 25 times greater increase in serum 25(OH)D levels than an ethanol vehicle. Reference: Maalouf et al. J. Clin. Endocrinol. Metab. 93: 2693 -2701, 2008 Remember: MCT is a main ingredients of D-Sorb/VESIsorb® • Improved lymphatic absorption Vitamin D 3 absorption is associated with lymphatic transport. Reference: Cuiné JF et al. Pharmaceutical Research, 24: 748 -757, 2007 DSorb/VESIsorb formulation contains ingredients that are known to increase the lymphatic transport capacity Pure Science. Innovative Thinking. Unparalleled Quality 9