What is the bottleneck What is the bottleneck
What is the bottleneck?
What is the bottleneck? • ICSG 2000 – Yokohama, Japan • • • Protein production Protein purification Crystallization Data collection Data analysis Refinement
What is the bottleneck? • ICSG 2000 – Yokohama, Japan • • • Protein production Protein purification Crystallization Data collection Data analysis Model refinement
What is the bottleneck? • ICSG 2000 – Yokohama, Japan • • • Protein production Protein purification Crystallization Data collection Data analysis Model refinement
What is the bottleneck? • ICSG 2000 – Yokohama, Japan • • • Protein production Protein purification Crystallization Data collection Data analysis Model refinement
What is the bottleneck? • ICSG 2000 – Yokohama, Japan • • • Protein production Protein purification Crystallization Data collection Data analysis Model refinement
What is the bottleneck? • “Bottlenecks” 2006 – Washington, DC • • • Protein production Protein purification Crystallization Data collection Data analysis Model refinement
What is the bottleneck? • “Bottlenecks” 2006 – Washington, DC • • • Protein production Protein purification Crystallization Data collection Data analysis Model refinement
Useful technique 20% 15% Cooling in loop 10% oil f n l 5% o Co o g in 0% % glycerol required 25% Rob Thorne 0 1 5 10 50 100 Drop size (um) 500 1000 5000
Useful technique Rob Thorne 0 C ~1 cm -195 C l. N 2
Useful technique Rob Thorne ~0. 5 cm l. N 2 0 C -195 C
Useful technique Rob Thorne warm, dry N 2 ~0. 5 cm l. N 2 0 C -195 C
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