What is 5 billion worth Magda Gunn IMI

What is € 5 billion worth? Magda Gunn, IMI Scientific Project Manager

Drug discovery is complex

Key concepts Focus on unmet needs Competitive Calls for proposals Open collaboration in public-private consortia A partnership between EU Commission and the European Federation of Pharmaceutical Industries and Association (EFPIA) Data sharing, dissemination of results… Industry contribution is in kind

Typical IMI project Industry Private Investment in kind Pharma 1 Pharma 2 Pharma 3 EU Public Funding cash Pharma 4 Pharma 5 Pharma 6 SMALL AND MEDIUM-SIZED ENTERPRISES ACADEMIA PATIENTS’ ORGANISATIONS HOSPITALS REGULATORS

Many stakeholders many expectations

17 68 2. 6 billion 2. 7 billion CALLS FOR PROPOSALS PROJECTS COMMITTED REMAINING Infectious diseases Drug Discovery Brain disorders Metabolic disorders Drug safety Stem cells Data Management Cancer Inflamatory disorders Biologicals Geriatrics Vaccines Education and Training Lung diseases Sustainable chemistry Drug delivery Drug kinetics Relative Effectiveness 0% 5% 10% 15% 20% 25% 30% 35% 40%

Performance monitoring framework Scientific output Impact on drug development Impact on regulatory framework Business opportunities and sustainability Socio-economic impact Information, communication and dissemination

Scientific Output

IMI scientific output 1134 9359 2. 19 24% PUBLICATIONS CITATION IMPACT HIGHLY CITED 1134 publications by Dec 2014 224 20102011 427 376 2012 2013 2014

Benchmarking IMI vs. EU in various research fields Citation impact IMI vs. comparators 0. 0 IMI Genetics & Heredity FNIH Psychiatry MRC Clinical Neurology WT Neurosciences GCGH Rheumatology CSIRO Biochemistry & Molecular. . . C-Path Immunology EU-28 Pharmacology & Pharmacy World Toxicology ICMR Endocrinology & Metabolism 0 0. 5 1 1. 5 2 2. 5 IMI papers 0. 5 1. 0 1. 5 EU papers 2. 0 2. 5 3. 0 3. 5 4. 0

Collaboration delivers excellence Collaboration BETWEEN SECTORS 61% of IMI publications collaboration BETWEEN INSTITUTIONS INTERNATIONAL collaboration of IMI publications 75% 50% Citation impact 3 2 1 0 Cross-institution Collaborative Cross-sector Non-collaborative Data & analysis: Thomson Reuters (Custom Analytics & Engineered Solutions) International

Tracking collaborations across EU Co-authorship between IMI-supported researchers Calls 1 -4 Pre IMI funding award Post IMI funding award Data & analysis: Thomson Reuters (Custom Analytics & Engineered Solutions)

Securing regulatory relevance

Securing regulatory relevance New standards and best practices derived from IMI projects Number of scientific advice and qualified opinions initiated by the IMI projects at the EMA and FDA Number of regulatory guidelines derived from IMI projects

Business development and sustainability

IMI project patenting trends 20 patent applications 3. 2 patents per € 10 million of costs accepted by IMI

Business relevant outputs (n=50) Spin-offs breakdown New Projects Companies & joint ventures Foundations & non-profits

Job creation as a result of IMI projects 2 272 direct jobs created 13 000 indirect jobs* * https: //researchcouncil. files. wordpress. com/2013/08/walifescienceseconimpactstudy. pdf

Key stakeholder involvement

Promoting SME participation SMEs receive 18% of IMI funding 15% of IMI participants are SMEs Thanks to IMI the company went from 6 to 50 employees. Now they are ready to further expand. “ 1 st product released to the market in 2013 – IMI was instrumental in validation of the first cell line product, 2 nd product release planned this year, 3 rd diagnostic product in development. In preparation: a new patent filing to protect technologies for the creation of third generation human beta cell lines.

Conclusions A mix of quantitative indicators and qualitative assessment is needed to fully address the “So what? ” question Need to address criteria relevant to both public and corporate worlds is a challenge Evaluation framework needs to incentivize desired outcomes and be the basis of a reward system Long term impact measures still remain challenging.

Thank you! Magda. Gunn@imi. europa. eu www. imi. europa. eu @IMI_JU