Week 6 Particle Based Drug Delivery Systems References
Week 6 Particle Based Drug Delivery Systems References LANGER, R. S. & PEPPAS, N. A. (1981) Present and future applications of biomaterials in controlled drug delivery systems. Biomaterials. 2, 201 -214.
Solvent Casting Method
Solvent Casting Method
Double Emulsion Method PROTEIN SOLUTION POLYMER-DCM SOLUTION ADD TO PVA IN WATER & MIX ULTRA SONICATION PRIMARY EMULSION (W/O) SECONDARY EMULSION (W/O/W) SOLVENT EVAPORATION FILTRATION AND DRYING
Spray Dried Microspheres • Inlet temperature • Polymer concentration • Pump feed rate • Aspirator ratio • Compressed air flow rate • Drug loadings
F. J. Wang and C. H. Wang, “Sustained Release of Etanidazole from Spray Dried Microspheres Prepared by Non-halogenated Solvents”, J. Controlled Release, 81 263 -280 (2002). Microsphere surface morphology using different polymer solution concentrations A B C D
F. J. Wang, T. K. Y. Lee and C. H. Wang , “PEG Modulated Release of Etanidazole from Implantable PLGA/PDLA Discs”, Biomaterials, 23 3555 -3566 (2002). . Degradation of microspheres PLGA 50: 50 1 month PLGA 85: 15 3 month PLGA 65: 35 1 month PDLA 3 month
F. J. Wang, T. K. Y. Lee and C. H. Wang , “PEG Modulated Release of Etanidazole from Implantable PLGA/PDLA Discs”, Biomaterials, 23 3555 -3566 (2002). Modulation of release by PEG small discs (diameter = 5 mm, thickness =1 mm) large discs (diameter =13 mm, thickness = 1 mm)
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