Weed Pot Reefer Cannabis Anybody want to get
Weed, Pot, Reefer, Cannabis Anybody want to get a pizza? Biology/Psychology 3506
Introduction • Cannabis sativia • May also be other species (C. Indica) • One type is actually very low in THC and quite useful for cloth, rope, paper, etc. • Speaking of THC, it is the active ingredient in pot • Delta-9 -Tetrahdrocannabinol • Also Delta-8 - Tetrahdrocannabinol • Delta 9 is the biggie though
Administration • You can: • Eat it • Cookies, brownies • Smoke it • Joints, bongs, onehits • Hash and hah oil/weed oil • Drink it • Tea
‘Roll Your Own’ • Recently some synthetics have been developed • Don’t work as well as taking a hit off a Doobie • synhexyl • nabilone • Used in chemo treatment • dronabinol • (Marinol)
A little History • Initially spread by the Scythians • Where do you think the word Assassin comes from? • Chinese liked it, then they got the munchies and ordered Chinese food… • 6000 years ago • Got to India • Ganja and bhang
More History • In Europe and North America it was used for rope, cloth etc, intoxicating effects were noticed for years. • George Washington grew Hemp! • Gauthier’s ‘Le Club de Hachichins’ • Big as a cash crop in the States • (Still is…) • 1937 Marijuana Tax Act • 1970 Became Illegal in the US, Canada.
Recent History • Medical Marijuana laws in US and Canada • Feds actually growing weed in Flon, MB • Netherlands • Pot was almost legal in Canada in 2002, and will be in mid 2018 • Washington and Colorado
Absorption, Distribution, Etc…. . • VERY lipid soluble • Very slowly absorbed when administered orally • 3 x the dose than for smoked pot • Much longer lasting high • Smoking works way better • 50% of THC goes to lungs • Then to your brain
Absorption etc… • Many of the compounds created during burning are also psychoactive • Metabolized in liver mostly • Other places too • Lungs if smoked • Intestines if eaten • Metabolites are active • Cannabidiol blocks metabolism of THC
Neuropharmacology • Radioactive Levonantradol • (syntehtic cannabinoid) • Group in the next lab found a gene that coded for a receptor site • The maps matched! • Science is cool
So, where are the receptors for THC? • Cortex • Hippocampus • Cerebellum • Basal ganglia • Spinal cord • Brainstem • Hypothalamus • Spleen!
Effects • Bloodshot eyes • Droopy eyes • The drys • The munchies • Increased heart rate • Reduction of pressure of fluid in eye!
Capitalism
More effects • Stops nausea • Anticonvulsant • Antibiotic • Sleep effects • Everything is way funny • Mood changes
Even more effects • Analgesic • Memory • Recall not recognition • STM • HP effect? • Attentional effects
Hey man, this weed has lots of effects…. • DON’T DRIVE A CAR • Biphasic effects on SMA • Taming effect • Timing effects • Crystal (2003) • Reverse Tolerance? • Mild Withdrawal
You wanna get high? • Other species don’t do it • Titration • Usually smoked in groups • Most users are casual users • ritualistic
Cannabidiol Effects • Anti psychotic effects • Decreases limbic system activity • Fewer memory effects • It is an antagonist to the cannabanoid receptor • Much of this may be due to it being a 5 Ht agonist and stabilizing effect on NMDA pathways
Bad stuff • Violence? • Makes crazy people go nuts • Freak outs • Gateway drug? • Reproductive effects? • Cancer, lung disease? • Probably, but how much is smoked?
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