Wednesday 17 September Finish Ch 11 Endocrine System

Wednesday, 17 September Finish Ch 11 Endocrine System Start Ch 6 Nervous System • Psychology Seminar: Thursday, 11 am Dr. Steven St. John on “Salt Appetite” • Examples of endocrine disorders • Stress and cortisol • Ch 6 Part A Basic terms • Quiz on Monday (Endocrine Chapter & Endocrine Case Studies Lab)

Tropic hormones control the function Trophic hormones promote survival and growth of targets Short-loop Neg. Feed. Long-loop negative feedback Releasing Hormone Release Inhibiting Hormone

Endemic Goiter TRH TSH T 3 & T 4 Goiter Elevates basal metabolic rate, potentiates response to EPI • Symptoms of hypothyroidism • Levels of TSH and TH? • Explain enlarged thyroid gland • Cause: Inadequate dietary intake of iodine • Treatment?

Age 16, 33, 52 No Relation!

Acromegaly • Excessive growth of bones and soft tissues of face and hands, and feet. • Hypersecretion of Growth Hormone from adenohypophysis or ectopic tumor • Treatment? • Transphenoidal resection/ablation with focal radiation • Somatostatin analogs • GH receptor blockers Compare to Pituitary Gigantism

Vasopressin Cytokines from immune cells CRH from Hypothalamus Physical trauma Prolonged exposure to cold Prolonged intense exercise Infection Sleep deprivation Pain Fright Emotional distress ACTH from Ant. Pit ⇧Cortisol secretion from Adrenal Cortex Mobilize fuel from muscle & adipose tissue Suppress non-essential functions (reproduction & growth) Suppress inflammatory & immune responses Cushing’s Syndrome Potentiates response to EPI (vascular smooth Excess Cortisol from 1) adrenal cortex tumor (primary) or muscle) 2) hypersecretion of ACTH from anterior pituitary (secondary)

Endocrine disorders • Hypersecretion – Primary – Secondary • Hyposecretion – Primary – Secondary hypothalamus CRH Anterior pituitary ACTH Adrenal Cortex Cortisol

Lab Next Week • Critically reading a Scientific Paper King et al. , 1999. Effects of oral androstenedione on serum testosterone and adaptations to resistance training in young men. JAMA 281: 2020 -2028

Questions so far?

Neurons? Endocrine cells? Neuroendocrine cells?

Endocrine System Nervous System • Common features • Major differences