WEARABLE SENSORS MJFFS WEARABLE SENSOR PLATFORM TO QUANTIFY

WEARABLE SENSORS: MJFF'S WEARABLE SENSOR PLATFORM TO QUANTIFY PD IN CLINICAL TRIALS AND ACROSS PATIENT POPULATIONS KEN KUBOTA DIRECTOR OF DATA SCIENCE AT THE MICHAEL J FOX FOUNDATION SHAHAR SHPIGELMAN INTEL BIG DATA ANALYTICS

MJFF IS THE WORLD’S LARGEST NONPROFIT FUNDER OF PD RESEARCH OUR MISSION TO ACCELERATE THE DEVELOPMENT OF IMPROVED THERAPIES, AND ULTIMATELY A CURE, FOR PEOPLE LIVING WITH PARKINSON’S DISEASE TODAY. » $500 MILLION IN RESEARCH FUNDED TO DATE » $70 MILLION IN RESEARCH GRANTS FUNDED IN 2014 » 1, 500 PROJECTS FUNDED TO DATE » 500 ACTIVE GRANTS IN CURRENT PORTFOLIO » 30% OF FUNDED PROJECT ARE OUTSIDE OF THE U. S. » FUND ACADEMICS, BIOTECHS AND PHARMA 2

THE PAUCITY OF “REAL” CLINICAL MEASURES, COST OF TRIALS AND THE ABILITY TO SCALE. Need for more sensitive diverse measures COST OF TRIALS are in the scales of $M Detect natural progression <1 yr VERY SMALL number of patients contribute to research Continuous measures in the real world AVERAGE TRIAL SIZE < 100 PATIENTS 3

HISTORY Big data analytics IOT 4

IMPORTANT NEXUS IN TECHNOLOGY “Biosensing wearable products being developed today could not have existed just 4 years ago” • Bluetooth Low Energy radio, i. Phone 4 s was the 1 st to implement • Wireless Qi charging coil standard • MEMS accelerometers price drops 5 x 5

PROGRAM TO IMPLEMENT WEARABLE SENSOR TECHNOLOGIES FOR PD AIMS: • SPEED TRIALS WHILE REDUCING COST • IDENTIFY NEW PHENOTYPES OF PARKINSON’S DISEASE • IMPROVE THE QUALITY OF CARE OF PARKINSON’S DISEASE PATIENTS

THE SYSTEM RESEARCHER MANAGE THE DISEASE USING DATA Data for Analysis Analytics BIG DATA CLOUD Patient and CLINICIAN INSIGHT / VALUE Clinically Meaningful Data 7

OUR DATA INFRASTRUCTURE Historical trials Patient de-identification • Patient stratification (unsupervised analysis) • Disease progression models (machine learning) • Report sharing Curation Time series data model ETL tool Initial phase of portal 8

KEY LEARNING 9

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Iterative Design and Discovery

CLINICAL TRIALS DATA GATHERING TRIAL L-DOPA RESPONSE TRIAL Create and Validate Algorithm & Measures SCRIPPS TREMOR TRIAL 17

Population Trials POPULATION STUDY Generate insights Using Big data analytics REAL PD FOX INSIGHT WEAR 18

THE ROAD AHEAD » THIS SUMMER: – INTEGRATION OF MPOWER AS OUR PILOT IPHONE OFFERING » THIS WINTER: – INTEGRATION OF FEATURES ACROSS BOTH ANDROID AND IOS AS OUR CROSS PLATFORM OFFERING 19

CALL TO ACTION » Let’s free the data • • Write broad consent forms that allow data to be shared openly Let the patient own the data » Put research in the hands of the patient • Come to us with your ideas and proposals

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