WATER EXCRETION NA or other 5 HT 1
- Slides: 12
- WATER EXCRETION NA or other 5 HT 1 or 2 Enk + + 5 -HT Proximal Contraction + + 5 HT 3 5 HT 4 NANC ACh - + Enk Distal Relaxation -- , ACh D 2 - + PERISTALTIC REFLEX DA
Water Excretion - X ACh NA or other ACh + Motility +
Don’t forget hormone actions esp. motilin, somatostatin ACh + Motility
ACh D 2 + - DA
X ACh D 2 - METOCLOPRAMIDE + DA
5 -HT Proximal Contraction Distal Relaxation + + 5 HT 3 5 HT 4 NANC ACh - + ACh + PERISTALTIC REFLEX
CISAPRIDE TEGASEROD (5 HT 4 agonists) 5 HT 4 ACh +
ONDANSETRON ALOSETRON (5 HT 3 antagonists) 5 -HT X + INCREASED CONTRACTION BUT DECREASED MOTILITY! 5 HT 3 NANC ACh +
Enk -- , ACh +
- NA or other 5 HT 1 or 2 Enk + + 5 -HT + inhibition of 5 -HT mediating segmentation (not shown) Enk -- , ACh +
- NA or other 5 HT 1 or 2 + 5 -HT DIPHENOXYLATE LOPERAMIDE , ACh +
ALVIMOPAN and METHYLNALTREXONE are opioid receptor antagonists that increase motility and increase secretion NA or other 5 HT 1 or 2 Enk + + CISAPRIDE and TEGASEROD are 5 Ht 4 agonist s that increase motility The “SETRONS”are 5 Ht 3 antagonist s that inhibit peristalsis 5 -HT + + 5 HT 3 5 HT 4 NANC ACh - + Enk -- , DIPHENOXYLATE & LOPERAMIDE are opioids that decrease motility and reduce secretion ACh D 2 + - DA METOCLOPRAMIDE is a DA antagonis that acts as cholinomimetics to increase motility