Vitamins and Minerals 1 The Nature of Vitamins

Vitamins and Minerals 1

The Nature of Vitamins l l l 2 Vitamins are organic (carbon) compounds needed for normal function, growth and maintenance. Vitamins are cofactors, they don’t do anything by themselves. They are not a source of calories.

Fat Soluble Vitamins 3 l A – orange, carotenoids, vision, antioxidant- used as color and antioxidant l D – we make it with sunlight, deficiency causes rickets, in milk, regulates Ca: P ratios l E – tocopherols, antioxidants, role in preventing stroke, cancer, heart disease- used as antioxidant l K – contributes to blood clotting factor

Vitamin Requirements l Daily Values (DV): standard nutrient intake values developed by FDA – Includes DRIs (Daily Recommended Intakes for Individuals) and (DRVs) Daily Recommended Values (Proteins, etc. ) – Disease prevention – Best met through a consumption of a wide variety of foods

Vitamin Requirements l 5 Dietary Reference Intakes (DRI): recommendation for individuals (more accurate, but would be impossible to label) – Age – Gender – Pregnancy – Lactation

Vitamin Requirements l l 6 Daily Reference Values (DRV): standards established for protein and other dietary components lacking a RDA or nutrient standard Constitute part of the Daily Values (DV) used on food labels

Dietary Supplements $6 Billion Market l l They are classified as “Nutritional Supplements” They are not foods, and not drugs. * Supplements are “Product intended to supplement the diet and contains vitamins, minerals, botanicals, amino acids, and their extracts. ” NOT consumed as a food replacement Loosely regulated, “not evaluated by FDA” By definition a “drug” is used to “prevent, treat or cure” disease. These terms cannot be used with supplements. Use of some supplements is backed by scientific data.

Vitamin A Lots of double bonds, good anti-oxidant 8

Vitamin A l l l 9 Carrotinoids Used in food industry as a colorant (orange) (label friendly) Antioxidant (label friendly) Stored in liver Important for sight – Deficiency causes ~500, 000 cases of “night blindness” worldwide Genetically engineered rice with high Vitamin A can prevent night blindness Carrotenosis

Vitamin D 10 l Also known as calciferol due to its role in calcium absorption l Main role is to maintain calcium and potassium levels l It is the only fat soluble vitamin that we can make- in the presence of sunlight l Can be made from cholesterol

Vitamin D l l 11 Can be stored in fat tissues (as can all fat soluble vitamins) Elderly and shut ins are at risk- not enough sunlight We get vitamin D form fortified milk and cereal Toxicity is very dangerous – Occurs only from excess supplementation – Can lead to calcium deposits in kidneys, heart and blood vessels

Vitamin D Rickets can be caused by lack of sunlight, but also from insufficient calcium. Vitamin D linked to calcium absorption. (Rickets reported in NYC. ) 12

Vitamin E l l l 13 A family of eight naturally occurring compounds Used as an anti-oxidant in foods Since aging is considered an “oxidation” reaction, many “anti-oxidants” are used as dietary supplements Deficiencies are not well understood Role is stroke, cancer, heart, and immune response Americans spend $300 million per year on vitamin E supplements

Vitamin K 14 l Contributes to synthesis of seven blood clotting factors l Can be reactivated to continue biological action l Works as a cofactor for an enzyme that makes two bone proteins

Water Soluble Vitamins l l 15 Relatively cheap to add to food Only Vitamin C is used for its functionality

Water Soluble Vitamins l l l l l 16 B 1, thiamine B 2, riboflavin B 6, pyridoxamine B 12 Biotin Panothenic acid Niacin Folacin Vitamin C

Water Soluble Vitamins l Vitamin B 1 – Thiamine – Involved in carbohydrate metabolism – Helps body metabolize glucose, affects central nervous system – Deficiency causes Beri beri (Singlese, “I can’t, I can’t”) l B 2 - riboflavin – Energy metabolism

Water Soluble Vitamins l B 6 - Pyridoxamine – l B 12 – – 18 Neurotransmitter, co-enzyme in over 100 reactions Development of red blood cells Lack of it makes one anemic Hard for vegans to get

Water Soluble Vitamins l Biotin – – – l Panthothenic acid – – 19 Involved in fatty acid synthesis Deficiency causes skin disease and hair loss Found in many foods Essential for metabolism of carbohydrates, protein, alcohol and fat

Water Soluble Vitamins l Choline – – 20 A major component of cell membranes Folacin = Folate = Folic acid Deficiency causes neural tube defects – in utero Took Rutgers Professor 20 years to for FDA approval as enrichment Why?

Vitamin C l l 21 Ascorbic acid Very inexpensive to add to food, marketing tool. Antioxidant Deficiency leads to bleeding gums, hemorrhages High in citrus fruits, limes, (Limeys)

Vitamin C - Scurvy 22

Niacin (B 3) l l Energy metabolism Disease – pellagra – The Four D’s – – 23 Dermatitis Diarrhea Dementia Death

Minerals l 24 Issues – Absorption – Bioavailability

Minerals l Percent of Body weight – – – – 25 Calcium Phosphorus Potassium Sulfur Sodium Chloride Magnesium Iron 2% 1% 0. 3% 0. 2% 0. 1% 0. 05% 0. 04%

Minerals l 26 Calcium – 99% is structural – ~25% absorption – Vitamin D aids absorption – 75% is obtained from dairy products – Many products are fortified with it – Built in youth, lost in maturity Very hard for vegans to get enough calcium

Calcium l 27 Osteoporosis – a pediatric disease with geriatric consequences – 1. 5 million fractures each year - major cause of subsequent mortality (25% within one year) – 14 billion in direct health cost – 25 million women at risk – DRI women 600 – 800 mg/day National Osteoporosis Foundation www. nof. org

Calcium 28

Risk Factors- By Mayo Clinic staff Your gender. Age. Race. Frame size. Eating disorders. Low calcium intake. Excess soda consumption (Ca: P ratio). The link between osteoporosis and caffeinated sodas isn't clear, but caffeine may interfere with calcium absorption and its diuretic effect may increase mineral loss. In addition, the phosphoric acid in soda may contribute to bone loss. Bone density can be improved at any time.

Soda is the devil’s drink l l 30 Extra calories Poor nutrient density Interferes with calcification Replaces more nutritious drinks

31

Minerals 32 l Phosphorus – Easily absorbed by the body – Enhanced by Vitamin D – Deficiency are rare – Soda, phosphoric acid l Potassium – A primary electrolyte in blood – Associated with lower blood pressure – Athletes

Minerals l 33 Sodium and Chloride – Added during processing – Enhances flavor – We consume 2 X of what we need (DV = 2. 4 grams, 1/10 ounce) (show) – Excess Sodium can lead to hypertension l High blood pressure l Salt sensitivity – genetics and race

Salt – Uses in Food l l l l 34 Enhances other flavors, cuts cost Salty taste, per se Increases consumer acceptance Raises boiling point of liquids (pasta) Masks bitter tastes Food safety Water binding

Minerals 35 l Sulfur – Necessary for collagen formation l Magnesium – Abundant in plants

Minerals l Iron – – – Most common and easily preventable deficiency Needed for oxygen absorption, immune function, developmental performance Poor absorption from plant sources Low iron causes anemia, especially in menstruating women Toxicity l 6 – 12 vitamins with 100% iron content will kill a small child (The dose makes the poison. )

Fortification vs Enrichment Fortification - restores lost nutrients due to processing l Enrichment – adds nutritional value to meet a specific standard l Old London Restaurant Style Croutons. Seasoned Sourdough. Enriched Bread, [Enriched Flour (Flour, Niacin, Ferrous Sulfate, Thiamin Mononitrate, Riboflavin, Folic Acid), Water, Yeast, Sugar, Salt, Partially Hydrogenated Soybean Oil , Vinegar, Ascorbic Acid] Bean Oil with BHT added as a Dextrin

Enriched Uranium “Enriched Uranium