VIETNAM MILITARY MEDICAL UNIVERSITY LOGO RELATIONSHIP BETWEEN THE

VIETNAM MILITARY MEDICAL UNIVERSITY LOGO RELATIONSHIP BETWEEN THE DIFFERENTIATION OF HEPATOCELLULAR CARCINOMA WITH A NUMBER OF PARACLINICAL INDECES Doctor Nguyen Thuy Linh

LOGO BACKGROUND Worldwide cancer mortality statistics, GLOBOCAN 2012: Clinic Paraclinic Differentiation HCC Histopathology

PURPOSE LOGO 1. Study of clinical characteristics and histopathology of HCC 2. Study relationship between the differentiation of HCC with a number of paraclinical indeces: AFP, GOT, GPT, Total Bilirubin and Albumin.

LOGO GENERAL Variants of HCC clearcell Pleomorphic fibrolamellar sarcomatoid oncocytic sclerosing small

GENERAL Differentiation of HCC Well differentiated Moderately differentiated Poorly differentiated Undifferentiated LOGO

Objects and Methods LOGO 53 patients diagnosed with HCC Histopathology Differentiation Age, Sex Clinic History Combined diseases Rea lat diff ionship eren tiati with on Paraclinic Microbiological test Hepatitis viruses AFP Imaging tests Biochemical test GOT, GPT Albumin Bilirubin

RESULTS AND DISCUSSION LOGO Age and sex: Our result Vauthey Le Minh Huy Average 59, 3 59 54, 8 Group >60 years 50, 9% Male/female ratio 4, 3/1 3, 9/1 Vu Minh Huy 35, 1% 34, 8% 3, 4/1 6, 8/1

RESULTS AND DISCUSSION LOGO The proportion of patients with HCC was infected hepatitis viruses, Alcoholism and combined diseases Japan Le Minh Huy Vu Minh Thang HBV 19, 5% 66, 1% 86% HCV 65, 5% 21, 7% 10, 5% Alcoholism 22, 2%

RESULTS AND DISCUSSION LOGO Tumor number and size Number Size Our result Vauthey Vu Minh Thang Thai Doan Ky The world 1 tumor 69, 8% 67% 76, 2% 57, 1% ≥ 2 tumors 30, 2% 33% 23, 8% 42, 9% Average 6, 4 cm 5 cm 8, 43 cm 7, 8 cm 4 -5 cm >5 cm 58, 5% 63, 95% 87, 6% 46, 3%

LOGO RESULTS AND DISCUSSION Stage STAGE Child-Pugh (%) Barcelona (%) VU MINH THANG THAI DOAN KY TNM Minagawa A 66, 7 94, 5 I 16, 3 B 33, 3 II 53, 8 A 17, 44 11, 4 III 23, 7 B 70 78, 1 IVA 6, 6 C 12, 8 10, 5 IVB 0, 6

RESULTS AND DISCUSSION Differentiation: G 1 G 2 Differentiation (%) Vauthey Le Minh Huy G 1 12 12, 8 G 2 43 67, 1 G 3 45 15, 7 G 4 1 4, 5 G 3 LOGO

RESULTS AND DISCUSSION LOGO RELATIONSHIP BETWEEN THE DIFFERENTATION OF HEPATOCELLULAR CARCINOMA WITH A NUMBER OF PARACLINICAL INDEXES * RELATIONSHIP BETWEEN THE DIFFERENTATION WITH AFP Authors AFP ≥ 200 ng/ml Our result 57, 7% Le Minh Huy 45, 4% Thai Doan Ky 33, 3% The lower the differentiation of HCC, the higher the rate of patients with AFP> 200 ng/ml

RESULTS AND DISCUSSION LOGO ** RELATIONSHIP BETWEEN THE DIFFERENTATION WITH GOT and GPT: The lower the differentiation of HCC, the higher proportion of patients with GOT/GPT <1

RESULTS AND DISCUSSION LOGO *** RELATIONSHIP BETWEEN THE DIFFERENTATION WITH TOTAL BILIRUBIN AND ALBUMIN Total bilirubin increased (> 17μmol / l) and albumin decreased (<40 g/l) in groups of well, moderately and poorly differentiated HCC, is a statistically significant difference (p> 0. 05).

CONCLUSION LOGO 1. A number of clinical characteristics and histopathology of HCC Ø Ø Ø The average was 59. 3 ± 10. 9; The male / female ratio was 4. 3 / 1 60. 4% infected with HBV, 1. 9% with HCV and 47. 2% Alcoholism Mean tumor size : 6. 4 ± 3. 2 cm, 69. 8% 1 tumor. 50. 9% well differentiated, 34% moderately differentiated and 15. 1% poorly differentiated. GĐ: § Child-Pugh A : 69, 8%. § Barcenola (2005): 49, 1% the intermediate stage. § TNM theo AJCC (2010): 47, 2% IIIA stage. 50, 9% , BH vừa 34% và BH kém 15, 1%. 2. Relationship between the differentiation of HCC with a number of paraclinical indexes: AFP, GOT, GPT, Total Bilirubin and Albumin. ØThe lower the differentiation of HCC, the higher the rate of patients with AFP> 200 ng/ml and the higher proportion of patients with GOT/GPT <1 ØTotal bilirubin increased (> 17μmol / l) and albumin decreased (<40 g/l) in groups of well, moderately and poorly differentiated HCC, is a statistically significant difference

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