VH IVUS IVUS EEM Area Lumen Area EEM

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VH IVUS图像

VH IVUS图像

检测方法-灰阶IVUS测定斑块体积 EEM Area Lumen Area (EEM area — Lumen Area) * 斑�+中膜体� =外�力膜体� (EEM)-管腔体�

检测方法-灰阶IVUS测定斑块体积 EEM Area Lumen Area (EEM area — Lumen Area) * 斑�+中膜体� =外�力膜体� (EEM)-管腔体� (Lumen) Nasu et al. J Am Coll Cardiol Intv 2009; 2: 689 -96

氟伐他汀对斑块的影响 Effect of Fluvastatin on Progression of Coronary Atherosclerotic Plaque Evaluated by Virtual Histology

氟伐他汀对斑块的影响 Effect of Fluvastatin on Progression of Coronary Atherosclerotic Plaque Evaluated by Virtual Histology Intravascular Ultrasound J AM Coll Cardiol Intv 2009 既评价了他汀应用后对斑块体积的影响, 又评价了他汀对斑块组份的影响

JUPITER结果再分析: hs-CRP的下降是心血管获益的原因之一 人数 HR 安慰剂 7832 1. 11 hs. CRP 达到值 > 2 mg/L

JUPITER结果再分析: hs-CRP的下降是心血管获益的原因之一 人数 HR 安慰剂 7832 1. 11 hs. CRP 达到值 > 2 mg/L 4305 0. 77 hs. CRP 达到值 < 2 mg/L 3411 0. 42 安慰剂 7832 1. 11 hs. CRP降低 < 50 % 4143 0. 70 hs. CRP降低 > 50 % 3573 0. 51 P < 0. 001 0. 25 0. 5 有利于瑞舒伐他汀 1. 0 2. 0 有利于安慰剂 JUPITER Trial Study Group. www. thelancet. com Published online March 29, 2009 DOI: 10. 1016/S 0140 -6736(09)60447 -5 4. 0

JUPITER结果再分析: hs-CRP的下降是他汀的独立作用, 与LDL-C下降无关 JUPITER Trial Study Group. www. thelancet. com Published online March 29,

JUPITER结果再分析: hs-CRP的下降是他汀的独立作用, 与LDL-C下降无关 JUPITER Trial Study Group. www. thelancet. com Published online March 29, 2009 DOI: 10. 1016/S 0140 -6736(09)60447 -5

本研究:氟伐他汀降低LDL-C的同时 显著降低CRP和TG LDL-C TG hs-CRP 实验室指标较基线变化% 0 -10 -20 -30 -40 -50 -31. 8%

本研究:氟伐他汀降低LDL-C的同时 显著降低CRP和TG LDL-C TG hs-CRP 实验室指标较基线变化% 0 -10 -20 -30 -40 -50 -31. 8% -44. 5% -48. 9% Nasu et al. J Am Coll Cardiol Intv 2009; 2: 689 -96

《NATURE》动脉粥样硬化的可能干预点: 脂质代谢和炎症反应 At present, the two main conceptual approaches to therapy for atherosclerosis are

《NATURE》动脉粥样硬化的可能干预点: 脂质代谢和炎症反应 At present, the two main conceptual approaches to therapy for atherosclerosis are manipulation of plasma lipoprotein metabolism or cellular cholesterol metabolism, and manipulation of inflammatory processes. 迄今为止,干预脂质代谢和干预炎症反应是理论上 干预动脉粥样硬化的两大治疗手段 Darviel J et al 2008; 451: 904 -913