Vesicular Traffic II Endocytic and secretory pathways red

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Vesicular Traffic II

Vesicular Traffic II

Endocytic and secretory pathways red = secretory green = endocytic blue = recycling

Endocytic and secretory pathways red = secretory green = endocytic blue = recycling

Different coats are used for different transport steps in the cell

Different coats are used for different transport steps in the cell

Assembly and disassembly of clathrin coat

Assembly and disassembly of clathrin coat

Dynamin pinches clathrin coated vesicles from the membrane

Dynamin pinches clathrin coated vesicles from the membrane

Electron micrograph from Drosophila mutant

Electron micrograph from Drosophila mutant

Resting Chemical Synapse

Resting Chemical Synapse

Drosophila mutant can not recycle synaptic vesicles

Drosophila mutant can not recycle synaptic vesicles

SNARE proteins guide vesicular transport

SNARE proteins guide vesicular transport

Active Chemical Synapse

Active Chemical Synapse

Interaction of SNARE proteins while docking synaptic vesicle at nerve terminal

Interaction of SNARE proteins while docking synaptic vesicle at nerve terminal

Model for membrane fusion. Tight SNARE pairing forces water molecules from area between lipid

Model for membrane fusion. Tight SNARE pairing forces water molecules from area between lipid bilayers

Entry of HIV into lymphocytes

Entry of HIV into lymphocytes

Recruitment of cargo molecules into ER transport vesicles

Recruitment of cargo molecules into ER transport vesicles

Vesicular tubular clusters move along microtubules to carry proteins from ER to Golgi apparatus

Vesicular tubular clusters move along microtubules to carry proteins from ER to Golgi apparatus

Vesicular tubular clusters

Vesicular tubular clusters

Microtubules

Microtubules

Microtubules

Microtubules

DVD Clip 58

DVD Clip 58

3 -dimensional model of the Golgi Apparatus

3 -dimensional model of the Golgi Apparatus

Golgi apparatus in an algal cell

Golgi apparatus in an algal cell

ER – Golgi transitional zone in an animal cell

ER – Golgi transitional zone in an animal cell

Some enzymes are enriched in cis or trans compartments of the Golgi substrates specific

Some enzymes are enriched in cis or trans compartments of the Golgi substrates specific for certain enzymes such as acid phosphatase

Functional Compartmentalization of the Golgi Apparatus

Functional Compartmentalization of the Golgi Apparatus

Golgi apparatus stained with GFP

Golgi apparatus stained with GFP

Golgi apparatus can be polarly distributed In this fibroblast Golgi is facing the direction

Golgi apparatus can be polarly distributed In this fibroblast Golgi is facing the direction in which the cell is crawling

Drawing of goblet cell in the intestinal epithelium Secretes polysaccharide rich mucus into the

Drawing of goblet cell in the intestinal epithelium Secretes polysaccharide rich mucus into the small intestine Golgi is highly polarized to facilitate release of mucus through exocytosis at the apical domain

N-linked glycosylation because sugar is added to N of asparagine. original precursor oligosaccharide added

N-linked glycosylation because sugar is added to N of asparagine. original precursor oligosaccharide added to most proteins in the ER

Oligosaccharide chains are processed in the Golgi complex common core high-mannose

Oligosaccharide chains are processed in the Golgi complex common core high-mannose

Vesicular transport model

Vesicular transport model

Cisternal Maturation Model

Cisternal Maturation Model

Lysosome interior is different from cytosol

Lysosome interior is different from cytosol

Detection of acid phosphatase in lysosomes Small spheres may be vesicles delivering the enzyme

Detection of acid phosphatase in lysosomes Small spheres may be vesicles delivering the enzyme from the Golgi Apparatus

Unit 7 Endomembranes Unit 7 SECRETORY PATHWAY SecretoryUnit 7 Endomembranes Unit 7 SECRETORY PATHWAY Secretory
TOPIC VESICULAR TRAFFICKING GENERAL INTRODUCTION Vesicles Vesicular traffickingTOPIC VESICULAR TRAFFICKING GENERAL INTRODUCTION Vesicles Vesicular trafficking
Traffic Engineering Traffic Control Devices Traffic Control TrafficTraffic Engineering Traffic Control Devices Traffic Control Traffic
The role of endocytic pathways in cellular uptakeThe role of endocytic pathways in cellular uptake
Red acadmica y Red comercial Red Acadmica RedRed acadmica y Red comercial Red Acadmica Red
Chapter 13 Intracellular Vesicular Traffic The molecular mechanismsChapter 13 Intracellular Vesicular Traffic The molecular mechanisms
TRAFFIC POLICE DIRECTORATE Traffic Security Section TRAFFIC METODOLOGYTRAFFIC POLICE DIRECTORATE Traffic Security Section TRAFFIC METODOLOGY
TS 4273 Traffic Engineering Traffic Stream Characteristics TrafficTS 4273 Traffic Engineering Traffic Stream Characteristics Traffic
Safety on Traffic Stops Traffic Contacts A trafficSafety on Traffic Stops Traffic Contacts A traffic
AIR TRAFFIC ONTROL Air Traffic Control Air trafficAIR TRAFFIC ONTROL Air Traffic Control Air traffic
AIR TRAFFIC CONTROL Air Traffic Control Air trafficAIR TRAFFIC CONTROL Air Traffic Control Air traffic
Traffic Assignment Definition of Traffic Assignment Traffic AssignmentTraffic Assignment Definition of Traffic Assignment Traffic Assignment
On the Kinetics of Polyplex Endocytic Trafficking ImplicationsOn the Kinetics of Polyplex Endocytic Trafficking Implications
Endocytic network in plants trans Golgi network OskarEndocytic network in plants trans Golgi network Oskar
Mouse LYVE1 Is an Endocytic Receptor for HyaluronanMouse LYVE1 Is an Endocytic Receptor for Hyaluronan
Red Tide What is Red Tide Red TideRed Tide What is Red Tide Red Tide
COBERTURA RED GPON COBERTURA RED GPON COBERTURA REDCOBERTURA RED GPON COBERTURA RED GPON COBERTURA RED
RED EYE differential diagnosis RED EYE l RedRED EYE differential diagnosis RED EYE l Red
Red IRIS Red IRIS Red IRIS is aRed IRIS Red IRIS Red IRIS is a
RED EYE differential diagnosis RED EYE l RedRED EYE differential diagnosis RED EYE l Red
Red River Red River Settlement Red River SettlementRed River Red River Settlement Red River Settlement
Red Ravnoteza Nastanak kibernetike Aleksandra Obradovi RED RedRed Ravnoteza Nastanak kibernetike Aleksandra Obradovi RED Red
Constitutive and regulated secretion of secretory leukocyte proteinaseConstitutive and regulated secretion of secretory leukocyte proteinase
Lecture 12 The secretory pathway The fission andLecture 12 The secretory pathway The fission and