Very Smart Therapeutics Really smart Applications drugs Tumor

Very Smart Therapeutics Really smart Applications drugs

Tumor Killing Bacteria Tami Tolpa, Technology Review, 2007 Applications

Engineering for Distinct Really smart Environments Bloodstream Tumor drugs. Systems Cell Surface Intracellular

Engineering for Distinct Really smart Environments Bloodstream Shielding No Growth Tumor Activation Deshielding No Growth drugs. Systems Cell Surface Adhesion Secretion Invasion No Growth Actuation Intracellular Lysis Killing

Engineering for Distinct Really smart Environments Bloodstream High Glucose High O 2 Low lactate Tumor Low Glucose Low O 2 Low lactate drugs. Systems Cell Surface 1 -Integrin TF Antigen Her 2 Sialyl Lewis X Sensing Intracellular Vacuole Metabolites

Bacteria in the bloodstream Uncontrolled bacterial growth Sepsis Innate Immune responses Complement-mediated lysis Phagocytosis

Growth Rate Control Really smart drugs. Chassis Modifications to high-affinity iron transport “Conditional Starvation” of mutants requiring a non-mammalian metabolite Genetic circuits that actively regulate growth rate

Serum and Complement Really smart Resistance drugs. Chassis Increase serum half-life from <5 min to 4 hours K 1 phenotypes are robust to animal host Poorly antigenic

The Target Systemsmart Really drugs. Systems