versatility Xpanded Trilogy Series mixedmode ventilators versatility Xpanded

versatility Xpanded Trilogy Series mixed-mode ventilators

versatility Xpanded We’re expanding the versatility of our Trilogy Series mixed-mode ventilators • Expanding ventilatory support • Expanding volume targeting • Expanding clinical control Confidential Sector, MMMM dd, yyyy, Reference 2

Expanding ventilatory support • Mouthpiece ventilation (MPV) • Increased pressure support to 40 cm H 2 O Confidential Sector, MMMM dd, yyyy, Reference 3

Expanding ventilatory support Mouthpiece ventilation (MPV) MPV is a form of volume ventilation whereby the patient’s normal state is disconnected from the ventilator and the patient initiates a breath, as needed, through an oral interface. Confidential Sector, MMMM dd, yyyy, Reference 4

What type of patient could benefit from MPV? Conditions with respiratory muscle dysfunction • Muscular dystrophies • ALS • Other myopathies: acid maltase deficiency, polymyositis, mitochondrial disorders • Neurological disorders: spinal muscular atrophies (SMA l, lll) • Neuropathies: Guillain-Barre syndrome, multiple sclerosis • Skeletal pathologies such as kyphoscoliosis, rigid spine syndrome Confidential Sector, MMMM dd, yyyy, Reference 5

Traditional neuromuscular disease clinical pathway Dx NIV night Confidential NIV day and night NIV night Sector, MMMM dd, yyyy, Reference Trach MPV day……………… 6

Which would patients choose? Confidential Sector, MMMM dd, yyyy, Reference 7

Why isn’t MPV more widely utilized? • Familiarity with current trends in NIV therapy • Existing vents require significant modification • Perceived risk and anxiety about the modifications Confidential Sector, MMMM dd, yyyy, Reference 8

What is the risk of using Trilogy’s MPV feature • The MPV feature represents no more risk than any other form of NIV • MPV may be used an entire lifetime by some neuromuscular patients and may extend the quality of life for patients who will eventually need invasive ventilation Confidential Sector, MMMM dd, yyyy, Reference 9

Kiss trigger and MPV support system • A new ‘kiss’ trigger with signal flow technology detects when the patient engages and disengages from the mouthpiece to deliver on-demand ventilation • This feature combines with a mouthpiece ventilation (MPV) support system to enhance ease of use Confidential Sector, MMMM dd, yyyy, Reference 10

PN 1102866 – MPV disposable circuit 10 pk • Each circuit kit contains two mouthpiece options, the angled mouthpiece and a straw, and all of the necessary adapters for each • The mini flex tube is optional; it should be in place for patients who appreciate the added comfort, but removed for patients that have extremely limited mobility of the head Confidential Sector, MMMM dd, yyyy, Reference 11

PN 1102862 – MPV support system • Each support system kit contains an assembled clamp and 2 ft. bendable tube holder, and one MPV disposable circuit • The clamp can be modified for rail or flat mounting Confidential Sector, MMMM dd, yyyy, Reference 12

Expanding ventilatory support Trilogy Series mixed-mode ventilators are lightweight, versatile and easy to use. The addition of MPV is a unique upgrade that offers an opportunity to improve the quality of life for patients and the possibility of increasing the time before a tracheostomy becomes a patient’s only option. Confidential Sector, MMMM dd, yyyy, Reference 13

Increased pressure support (PS) • Pressure support is increased to 40 cm H 2 O Confidential Sector, MMMM dd, yyyy, Reference 14

versatility Xpanded We’re expanding the versatility of our Trilogy Series mixed-mode ventilators • Expanding ventilatory support • Expanding volume targeting • Expanding clinical control Confidential Sector, MMMM dd, yyyy, Reference 15

Expanding volume targeting • AVAPS-AE • Adjustable AVAPS Confidential Sector, MMMM dd, yyyy, Reference 16

AVAPS-AE is a auto-titration mode of noninvasive ventilation designed to better treat respiratory insufficiency patients (OHS, COPD and NMD) in the hospital and homecare environments Achieving a targeted volume is now completely automatic • Proven performance of AVAPS • Auto EPAP • Auto backup rate Confidential Sector, MMMM dd, yyyy, Reference 17

AVAPS-AE Auto EPAP maintains patent upper airway at a comfortable pressure • Auto adjusting EPAP to meet changing patient needs • Maintains a patent airway Confidential Sector, MMMM dd, yyyy, Reference 18

AVAPS-AE Auto Back-up rate Auto backup rate provides comfortable assistance when needed • Auto backup rate is near resting rate • No manual adjustments (auto-default setting) Confidential Sector, MMMM dd, yyyy, Reference 19

Adjustable AVAPS • Adjustable AVAPS allows you to adjust the maximum rate at which the pressure support automatically changes to achieve the target tidal volume • It can be set from 1 cm H 2 O per minute to 5 cm H 2 O per minute • Allows clinician to customize the setting to the patient’s needs Confidential Sector, MMMM dd, yyyy, Reference 20

versatility Xpanded We’re expanding the versatility of our Trilogy Series mixed-mode ventilators • Expanding ventilatory support • Expanding volume targeting • Expanding clinical control Confidential Sector, MMMM dd, yyyy, Reference 21

Expanding clinical control • On-screen waveforms • Sensitive Auto-Trak Confidential Sector, MMMM dd, yyyy, Reference 22

On-screen waveforms allow clinicians to visually identify … • Triggering • Cycling • Synchrony Confidential Sector, MMMM dd, yyyy, Reference 23

Sensitive Auto-Trak • Provides an enhanced triggering response for patients with minimal respiratory effort • Digital Auto-Trak requires 6 cc of volume change to initiate a breath • Sensitive Auto-Trak requires 3 cc Inhale Exhale TIME Confidential Sector, MMMM dd, yyyy, Reference 24

Additional features In-line nebulizer treatment feature – Alarm sensitivity is adjusted for a 20 -minute period in order to reduce nuisance alarms Battery count/discharge on screen – Allows clinicians to easily determine life of battery Circuit type on screen Confidential Sector, MMMM dd, yyyy, Reference 25

Trilogy Series manual addendum The following warning and associated notes are removed in all Trilogy manuals: C-Flex, Bi-Flex and AVAPS are intended for use by adult patients Confidential Sector, MMMM dd, yyyy, Reference 26

At Philips Respironics we’re listening carefully to you and working toward solutions that contribute to healthy patients and healthy businesses. Confidential Sector, MMMM dd, yyyy, Reference 27