Uveitis Basics What is uveitis Uveitis Basics What

Uveitis: Basics What is uveitis?

Uveitis: Basics What is uveitis? In theory at least, it refers to inflammation of one or more components of the uvea

Uveitis: Basics What is uveitis? In theory at least, it refers to inflammation of one or more components of the uvea What three structures comprise the uvea?

Uveitis: Basics What is uveitis? In theory at least, it refers to inflammation of one or more components of the uvea What three structures comprise the uvea? The choroid, ciliary body and iris

5 Uveitis: Basics Uvea The eye can be thought to consist of three layers or tunics: A tough outer tunic consisting of the sclera and cornea; the inner retinal tunic; and, between the other two, the highly vascular tunic called the uvea

Uveitis: Basics What is uveitis? In theory at least, it refers to inflammation of one or more components of the uvea What three structures comprise the uvea? The choroid, ciliary body and iris Why did the first answer include the hedge ‘in theory at least’? Because in clinical parlance, some of the inflammatory conditions to which the term uveitis is applied involve non-uveal tissues (eg, the retina)

Uveitis: Basics What is uveitis? In theory at least, it refers to inflammation of one or more components of the uvea What three structures comprise the uvea? The choroid, ciliary body and iris Why did the first answer include the hedge ‘in theory at least’? Because in clinical parlance, some of the inflammatory conditions to which the term uveitis is applied involve non-uveal tissues (eg, the retina; vitreous)

Uveitis: Basics What is uveitis? In theory at least, it refers to inflammation of one or more components of the uvea What three structures comprise the uvea? The choroid, ciliary body and iris In a nutshell, how should the process of evaluating and managing a case of uveitis proceed? 1) The uveitis is ‘named; ’ ie, key aspects of the case are identified (more on this shortly). 2) The named case is ‘meshed; ’ ie, the identified aspects of the case are compared to the aspects known to characterize common uveitides (ditto). 3) Based on the meshing, a differential diagnosis list is generated. 4) Specific lab/imaging studies are obtained to winnow the differential, and identify the etiology. 5)

Uveitis: Basics What is uveitis? In theory at least, it refers to inflammation of one or more components of the uvea What three structures comprise the uvea? The choroid, ciliary body and iris In a nutshell, how should the process of evaluating and managing a case of uveitis proceed? 1) The uveitis is ‘profiled; ’ ie, key aspects of the case are identified (more on this shortly). 2) The named case is ‘meshed; ’ ie, the identified aspects of the case are compared to the aspects known to characterize common uveitides (ditto). 3) Based on the meshing, a differential diagnosis list is generated. 4) Specific lab/imaging studies are obtained to winnow the differential, and identify the etiology. 5) Treatment appropriate for the etiology is initiated. We will unpack all of these steps through the course of this slide-set!

Uveitis: Basics What is uveitis? In theory at least, it refers to inflammation of one or more components of the uvea What three structures comprise the uvea? The choroid, ciliary body and iris In a nutshell, how should the process of evaluating and managing a case of uveitis proceed? 1) The uveitis is ‘profiled; ’ ie, key aspects of the case are identified (more on this shortly). 2) The profiled case is ‘meshed; ’ ie, the identified aspects of the case are compared to the aspects known to characterize common uveitides (ditto). 3) Based on the meshing, a differential diagnosis list is generated. 4) Specific lab/imaging studies are obtained to winnow the differential, and identify the etiology. 5) Treatment appropriate for the etiology is initiated. We will unpack all of these steps through the course of this slide-set!

Uveitis: Basics What is uveitis? In theory at least, it refers to inflammation of one or more components of the uvea What three structures comprise the uvea? The choroid, ciliary body and iris In a nutshell, how should the process of evaluating and managing a case of uveitis proceed? 1) The uveitis is ‘profiled; ’ ie, key aspects of the case are identified (more on this shortly). 2) The profiled case is ‘meshed; ’ ie, the identified aspects of the case are compared to the aspects known to characterize common uveitides (ditto). 3) Based on the meshing, a differential diagnosis list is generated. 4) Specific lab/imaging studies are obtained to winnow the differential, and identify the etiology. 5) Treatment appropriate for the etiology is initiated.

Uveitis: Basics What is uveitis? In theory at least, it refers to inflammation of one or more components of the uvea What three structures comprise the uvea? The choroid, ciliary body and iris In a nutshell, how should the process of evaluating and managing a case of uveitis proceed? 1) The uveitis is ‘profiled; ’ ie, key aspects of the case are identified. 2) The profiled case is ‘meshed; ’ ie, the identified aspects of the case are compared to the aspects known to characterize common uveitides. 3) Based on the meshing, a differential diagnosis list is generated. 4) Specific lab/imaging studies are obtained to winnow the differential, and identify the etiology. 5) Treatment appropriate for the etiology is initiated. (We will address all of these steps through the course of this topic. )

Uveitis: Profiling In the context of uveitis, to what does ‘profiling’ refer? 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated

Uveitis: Profiling 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, to what does ‘profiling’ refer? It refers to identifying three components of a uveitis case: 1) Germane aspects of the pt’s personal history, demographics, etc; 2) nonocular signs and symptoms associated with the uveitis; and 3)

Uveitis: Profiling 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, to what does ‘profiling’ refer? It refers to identifying three components of a uveitis case: 1) Germane aspects of the pt’s personal history, demographics, etc; 2) nonocular signs and symptoms associated with the uveitis; and 3) certain key features of the inflammation itself (eg, location, duration, etc)

Uveitis: Profiling 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, to what does ‘profiling’ refer? It refers to identifying three components of a uveitis case: 1) Germane aspects of the pt’s personal history, demographics, etc; 2) nonocular signs and symptoms associated with the uveitis; and 3) certain key features of the inflammation itself (eg, location, duration, etc) What is the goal of the profiling process?

Uveitis: Profiling 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, to what does ‘profiling’ refer? It refers to identifying three components of a uveitis case: 1) Germane aspects of the pt’s personal history, demographics, etc; 2) nonocular signs and symptoms associated with the uveitis; and 3) certain key features of the inflammation itself (eg, location, duration, etc) What is the goal of the profiling process? A concise declarative statement that captures the important features of the case; eg, ‘Ms. Jones is a 40 y. o. female of Middle-Eastern descent who presents with a chronic bilateral granulomatous panuveitis associated with headache and tinnitus. ’

Uveitis: Profiling 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, to what does ‘profiling’ refer? It refers to identifying three components of a uveitis case: 1) Germane aspects of the pt’s personal history, demographics, etc; 2) nonocular signs and symptoms associated with the uveitis; and 3) certain key features of the inflammation itself (eg, location, duration, etc) What specifically constitute the ‘germane aspects’ of a pt’s identity? --Age What is the goal of the profiling process? --Gender A concise--Ethnicity/race declarative statement that captures the important features of the case; eg, ‘Ms. Jones is a 40 history y. o. female of Middle-Eastern descent who presents with a --Geographic chronic bilateral panuveitis associated with headache and tinnitus. ’ --Familygranulomatous history --Social history --Vocational/avocational activities

Uveitis: Profiling 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, to what does ‘profiling’ refer? It refers to identifying three components of a uveitis case: 1) Germane aspects of the pt’s personal history, demographics, etc; 2) nonocular signs and symptoms associated with the uveitis; and 3) certain key features of the inflammation itself (eg, location, duration, etc) What specifically constitute the ‘germane aspects’ of a pt’s identity? --Age? What is the goal of the profiling process? --Gender? A concise--Ethnicity/race? declarative statement that captures the important features of the case; eg, ‘Ms. Jones is a 40 history? y. o. female of Middle-Eastern descent presents with --Geographic Of these, which three who are far-and-away theamost important? chronic bilateral panuveitis associated with headache and tinnitus. ’ --Familygranulomatous history? --Social history? --Vocational/avocational activities?

Uveitis: Profiling 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, to what does ‘profiling’ refer? It refers to identifying three components of a uveitis case: 1) Germane aspects of the pt’s personal history, demographics, etc; 2) nonocular signs and symptoms associated with the uveitis; and 3) certain key features of the inflammation itself (eg, location, duration, etc) What specifically constitute the ‘germane aspects’ of a pt’s identity? --Age What is the goal of the profiling process? These three are far-and-away the most important! --Gender A concise--Ethnicity/race declarative statement that captures the important features of the case; eg, ‘Ms. Jones is a 40 history y. o. female of Middle-Eastern descent who presents with a --Geographic chronic bilateral panuveitis associated with headache and tinnitus. ’ --Familygranulomatous history --Social history --Vocational/avocational activities

Uveitis: Profiling 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, to what does ‘profiling’ refer? It refers to identifying three components of a uveitis case: 1) Germane aspects of the pt’s personal history, demographics, etc; 2) nonocular signs and symptoms associated with the uveitis; and 3) certain key features of the inflammation itself (eg, location, duration, etc) What specifically constitute the ‘germane aspects’ of a pt’s identity? --Age? What is the goal of the profiling process? Of these three, which is far-and-away the most important? --Gender? A concise--Ethnicity/race? declarative statement that captures the important features of the case; eg, ‘Ms. Jones is a 40 history y. o. female of Middle-Eastern descent who presents with a --Geographic chronic bilateral panuveitis associated with headache and tinnitus. ’ --Familygranulomatous history --Social history --Vocational/avocational activities

Uveitis: Profiling 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, to what does ‘profiling’ refer? It refers to identifying three components of a uveitis case: 1) Germane aspects of the pt’s personal history, demographics, etc; 2) nonocular signs and symptoms associated with the uveitis; and 3) certain key features of the inflammation itself (eg, location, duration, etc) What specifically constitute the ‘germane aspects’ of a pt’s identity? Age is far-and-away the most important! --Age What is the goal of the profiling process? --Gender A concise--Ethnicity/race declarative statement that captures the important features of the case; eg, ‘Ms. Jones is a 40 history y. o. female of Middle-Eastern descent who presents with a --Geographic chronic bilateral panuveitis associated with headache and tinnitus. ’ --Familygranulomatous history --Social history --Vocational/avocational activities

Uveitis: Profiling 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, to what does ‘profiling’ refer? It refers to identifying three components of a uveitis case: 1) Germane aspects of the pt’s personal history, demographics, etc; 2) nonocular signs and symptoms associated with the uveitis; and 3) certain key features of the inflammation itself (eg, location, duration, etc) What specifically constitute the ‘germane aspects’ of a pt’s identity? --Age What is the goal of the profiling process? --Gender How specific does the agethat need to be? the important features of the case; A concise--Ethnicity/race declarative statement captures Age can considered in terms of stages of life; descent ie, infancy, childhood, eg, ‘Ms. Jones is abe 40 y. o. female of Middle-Eastern who presents with a --Geographic history adolescence, young adulthood, elderly chronic bilateral panuveitis associated with headache and tinnitus. ’ --Familygranulomatous history --Social history --Vocational/avocational activities

Uveitis: Profiling 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, to what does ‘profiling’ refer? It refers to identifying three components of a uveitis case: 1) Germane aspects of the pt’s personal history, demographics, etc; 2) nonocular signs and symptoms associated with the uveitis; and 3) certain key features of the inflammation itselfsigns (eg, and location, duration, etc) How does one go about identifying associated symptoms? Via a careful Review of Systems and Physical Exam What is the goal of the profiling process? A concise declarative statement that captures the important features of the case; eg, ‘Ms. Jones is a 40 y. o. female of Middle-Eastern descent who presents with a chronic bilateral granulomatous panuveitis associated with headache and tinnitus. ’

Uveitis: Profiling 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, to what does ‘profiling’ refer? It refers to identifying three components of a uveitis case: 1) Germane aspects of the pt’s personal history, demographics, etc; 2) nonocular signs and symptoms associated with the uveitis; and 3) certain key features of the inflammation itselfsigns (eg, and location, duration, etc) How does one go about identifying associated symptoms? Via a careful Review of Systems and Physical Exam What is the goal of the profiling process? needs tostatement be coveredthat in the ROS/PE? Everything!!!! A concise What declarative captures the important features of the case; -eg, ‘Ms. Jones is a 40 y. o. female of Middle-Eastern descent who presents with a -chronic bilateral granulomatous panuveitis associated with headache and tinnitus. ’ ----

Uveitis: Profiling 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, to what does ‘profiling’ refer? It refers to identifying three components of a uveitis case: 1) Germane aspects of the pt’s personal history, demographics, etc; 2) nonocular signs and symptoms associated with the uveitis; and 3) certain key features of the inflammation itselfsigns (eg, and location, duration, etc) How does one go about identifying associated symptoms? Via a careful Review of Systems and Physical Exam What is the goal of the profiling process? needs tostatement be coveredthat in the ROS/PE? Everything!!!! A concise What declarative captures the important features of the case; --Constitutional eg, ‘Ms. Jones is a 40 y. o. female of Middle-Eastern descent who presents with a --Neuro chronic bilateral granulomatous panuveitis associated with headache and tinnitus. ’ --ENT --Skin --Pulmonary --Cardiac --GI --GU --Musculoskeletal

Uveitis: Profiling 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, to what does ‘profiling’ refer? It refers to identifying (ie, profiling) two components of a uveitis case: 1) Germane aspects of the pt’s personal history, demographics, etc; and 2) Certain key features of the inflammation itself (eg, location, duration, etc) What isprecisely the goal of constitutes the profiling process? What ‘certain key features of the inflammation itself’ A concise declarative statement that captures the important features of the case; is the subject of the next section… eg, ‘Ms. Jones is a 40 y. o. female of Middle-Eastern descent who presents with a chronic bilateral granulomatous panuveitis. ’

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for?

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group?

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they?

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis The onset, duration and course of the uveitis The severity of the uveitis

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --? --? What are the four locations? The onset, duration and course of the uveitis The severity of the uveitis

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis What are the four locations? The onset, duration and course of the uveitis The severity of the uveitis

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis somethingvs vs something --Onset: Sudden insidious --Duration --Course How are onset, duration and course delineated? The severity of the uveitis

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration --Course How are onset, duration and course delineated? The severity of the uveitis

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious something --Duration: Limited vsvspersistent --Course How are onset, duration and course delineated? The severity of the uveitis

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course How are onset, duration and course delineated? The severity of the uveitis

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vsvsrecurrent something vs… vs chronic …something How are onset, duration and course delineated? The severity of the uveitis

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic How are onset, duration and course delineated? The severity of the uveitis

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis words --AC celltwograde two grade words --AC flare two score words --Vitreous haze How is severity determined?

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score How is severity determined?

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior? --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber, +/- cells found no further posterior than the anterior vitreous Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior? --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working. Anterior group appointed by the uveitis International Ocular Inflammation Society …Is divided into three subtypes based on what attribute? Cell location What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior? --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis It is called: --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: ? Acute vs recurrent vs ? chronic It is called: ? With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working. Anterior group appointed by the uveitis International Ocular Inflammation Society If cell is located… What was the task of the SUN Working Group? To standardize uveitis nomenclature ? ? What are they? The SUN classification system is based on three sets of criteria. The location of the uveitis --Anterior? --Intermediate --Posterior --Panuveitis What areand the three ‘cell locations’? The onset, duration course of the uveitis It is called: --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: ? Acute vs recurrent vs ? chronic ? It is called: ? With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working. Anterior group appointed by the uveitis International Ocular Inflammation Society If cell is located… What was the task of the SUN Working Group? To standardize uveitis nomenclature Exclusively In the AC and the The SUN classification system is based on three sets of criteria. vitreous What are they? in the AC anterior The location of the uveitis --Anterior? --Intermediate --Posterior --Panuveitis What areand the three ‘cell locations’? The onset, duration course of the uveitis It is called: --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: ? Acute vs recurrent vs ? chronic Exclusively in the AVit It is called: ? With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working. Anterior group appointed by the uveitis International Ocular Inflammation Society If cell is located… What was the task of the SUN Working Group? To standardize uveitis nomenclature Exclusively In the AC and the The SUN classification system is based on three sets of criteria. vitreous What are they? in the AC anterior The location of the uveitis --Anterior? --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis It is called: --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: ? Acute vs recurrent vs ? chronic Exclusively in the AVit It is called: ? With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working. Anterior group appointed by the uveitis International Ocular Inflammation Society If cell is located… What was the task of the SUN Working Group? To standardize uveitis nomenclature Exclusively In the AC and the The SUN classification system is based on three sets of criteria. vitreous What are they? in the AC anterior The location of the uveitis --Anterior? --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis It is called: --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs ? Iritis chronic Exclusively in the AVit It is called: ? With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working. Anterior group appointed by the uveitis International Ocular Inflammation Society If cell is located… What was the task of the SUN Working Group? To standardize uveitis nomenclature Exclusively In the AC and the The SUN classification system is based on three sets of criteria. vitreous What are they? in the AC anterior The location of the uveitis --Anterior? --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis It is called: --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs ? Iritis chronic Exclusively in the AVit It is called: Anterior cyclitis With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working. Anterior group appointed by the uveitis International Ocular Inflammation Society If cell is located… What was the task of the SUN Working Group? To standardize uveitis nomenclature Exclusively In the AC and the The SUN classification system is based on three sets of criteria. vitreous What are they? in the AC anterior The location of the uveitis --Anterior? --Intermediate --Posterior --Panuveitis Exclusively in the AVit The severity of the uveitis The onset, duration and --AC cell grade course of the uveitis --AC flare grade It is called: --Onset: Sudden vs insidious --Vitreous haze score --Duration: Limited vs persistent Anterior --Course: Acute vs recurrent vs Iritis Iridocyclitis chronic With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate? --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate? --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score When inflammatory cells aggregate in small clumps in the periphery, are these location of inflammation in… With respect to far uveitis: Wherewhat is the primary aggregates called? Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Snowballs Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head When the aggregates cover a much largerinvolved area Panuveitis? All three locations are equally of the far periphery, what are they called? Snowbanks

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointeduveitis by the Intermediate International Ocular Inflammation Society …Is divided into two subtypes based on what attribute? Whether it is idiopathic, vs associated with an What was the task of the SUN Working Group? infection or systemic inflammatory condition To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate? --Posterior --Panuveitis The onset, duration and course Itofisthe uveitis called: --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute ? vs recurrent vs chronic It is called: ? With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointeduveitis by the Intermediate International Ocular Inflammation Society If condition is… What was the task of the SUN Working Group? To standardize uveitis nomenclature Idiopathic idiopathic The SUN classification system is based on three sets of criteria. What are Not they? The location of the uveitis --Anterior --Intermediate? --Posterior --Panuveitis The onset, duration and course Itofisthe uveitis called: --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute ? vs recurrent vs chronic It is called: ? With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointeduveitis by the Intermediate International Ocular Inflammation Society If condition is… What was the task of the SUN Working Group? To standardize uveitis nomenclature Idiopathic idiopathic The SUN classification system is based on three sets of criteria. What are Not they? The location of the uveitis --Anterior --Intermediate? --Posterior --Panuveitis The onset, duration and course Itofisthe uveitis called: --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs Pars planitis chronic It is called: ? With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointeduveitis by the Intermediate International Ocular Inflammation Society If condition is… What was the task of the SUN Working Group? To standardize uveitis nomenclature Idiopathic idiopathic The SUN classification system is based on three sets of criteria. What are Not they? The location of the uveitis --Anterior --Intermediate? --Posterior --Panuveitis The onset, duration and course Itofisthe uveitis called: --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs Pars planitis chronic It is called: Intermediate uveitis With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior? --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the Posterior uveitis International Ocular Inflammation Society …Is divided into three subtypes based on what attribute? What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior? --Panuveitis The severity of the uveitis The onset, duration and --AC severity cell grade of the uveitis --AC course of the uveitis --AC cell flaregrade It is called: --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: ? Acute vs recurrent vs ? chronic --AC flare grade --Vitreous haze score ? With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the Posterior uveitis International Ocular Inflammation Society …Is divided into three subtypes based on what attribute? Inflammation location What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior? --Panuveitis The severity of the uveitis The onset, duration and --AC severity cell grade of the uveitis --AC course of the uveitis --AC cell flaregrade It is called: --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: ? Acute vs recurrent vs ? chronic --AC flare grade --Vitreous haze score ? With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the Posterior uveitis International Ocular Inflammation Society If inflammation is located… What was the task of the SUN Working Group? To standardize uveitis nomenclature ? ? What are they? The SUN classification system is based on three sets of criteria. The location of the uveitis --Anterior --Intermediate --Posterior? --Panuveitis ? The severity of the uveitis What are the and three ‘inflammation locations’? The onset, duration --AC severity cell grade of the uveitis --AC course of the uveitis --AC cell flaregrade It is called: --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: ? Acute vs recurrent vs ? chronic --AC flare grade --Vitreous haze score ? With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the Posterior uveitis International Ocular Inflammation Society If inflammation is located… What was the task of the SUN Working Group? To standardize uveitis nomenclature Exclusively in In both the choroid Exclusively The SUN classification system is based on three sets of criteria. What are they? the choroid and the retina in the retina The location of the uveitis --Anterior --Intermediate --Posterior? --Panuveitis The severity of the uveitis What are the and three ‘inflammation locations’? The onset, duration --AC severity cell grade of the uveitis --AC course of the uveitis --AC cell flaregrade It is called: --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: ? Acute vs recurrent vs ? chronic --AC flare grade --Vitreous haze score ? With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the Posterior uveitis International Ocular Inflammation Society If inflammation is located… What was the task of the SUN Working Group? To standardize uveitis nomenclature Exclusively in In both the choroid Exclusively The SUN classification system is based on three sets of criteria. What are they? the choroid and the retina in the retina The location of the uveitis --Anterior --Intermediate --Posterior? --Panuveitis The severity of the uveitis The onset, duration and --AC severity cell grade of the uveitis --AC course of the uveitis --AC cell flaregrade It is called: --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: ? Acute vs recurrent vs ? chronic --AC flare grade --Vitreous haze score ? With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the Posterior uveitis International Ocular Inflammation Society If inflammation is located… What was the task of the SUN Working Group? To standardize uveitis nomenclature Exclusively in In both the choroid Exclusively The SUN classification system is based on three sets of criteria. What are they? the choroid and the retina in the retina The location of the uveitis --Anterior --Intermediate --Posterior? --Panuveitis The severity of the uveitis The onset, duration and --AC severity cell grade of the uveitis --AC course of the uveitis --AC cell flaregrade It is called: --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs ? Choroiditis chronic --AC flare grade --Vitreous haze score ? With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the Posterior uveitis International Ocular Inflammation Society If inflammation is located… What was the task of the SUN Working Group? To standardize uveitis nomenclature Exclusively in In both the choroid Exclusively The SUN classification system is based on three sets of criteria. What are they? the choroid and the retina in the retina The location of the uveitis --Anterior --Intermediate --Posterior? --Panuveitis The severity of the uveitis The onset, duration and --AC severity cell grade of the uveitis --AC course of the uveitis --AC cell flaregrade It is called: --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs ? Choroiditis chronic --AC flare grade --Vitreous haze score Retinitis With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the Posterior uveitis International Ocular Inflammation Society If inflammation is located… What was the task of the SUN Working Group? To standardize uveitis nomenclature Exclusively in In both the choroid Exclusively The SUN classification system is based on three sets of criteria. What are they? the choroid and the retina in the retina The location of the uveitis --Anterior --Intermediate --Posterior? --Panuveitis The severity of the uveitis The onset, duration and --AC severity cell grade of the uveitis --AC course of the uveitis --AC cell flaregrade It is called: --AC flare grade --Onset: Sudden vs insidious --Vitreous haze score --Duration: Limited vs persistent Retinitis --Course: Acute vs recurrent vs Choroiditis Chorioretinitis or chronic Retinochoroiditis With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the Posterior uveitis International Ocular Inflammation Society If inflammation is located… What was the task of the SUN Working Group? To standardize uveitis nomenclature Optic nerve head Exclusively in In both the choroid Exclusively The SUN classification system is based on three sets of criteria. What are they? the choroid and the retina in the retina The location of the uveitis --Anterior --Intermediate --Posterior? --Panuveitis The severity of the uveitis The onset, duration and --AC severity cell grade of the uveitis --AC course of the uveitis --AC cell flaregrade It is called: --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs ? Choroiditis chronic --AC flare grade --Vitreous haze score Retinitis With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the Posterior uveitis International Ocular Inflammation Society If inflammation is located… What was the task of the SUN Working Group? To standardize uveitis nomenclature Optic nerve head Exclusively in In both the choroid Exclusively The SUN classification system is based on three sets of criteria. What are they? the choroid and the retina in the retina The location of the uveitis --Anterior --Intermediate --Posterior? --Panuveitis The severity of the uveitis The onset, duration and --AC severity cell grade of the uveitis --AC course of the uveitis --AC cell flaregrade It is called: --AC flare grade --Onset: Sudden vs insidious --Vitreous haze score --Duration: Limited vs persistent Retinitis --Course: Acute vs recurrent vs Choroiditis Neuroretinitis chronic With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis? The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score With respect to uveitis: Where is the primary location of inflammation in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The main vitreous cavity, +/- the peripheral retina and/or pars plana Posterior uveitis? The retina, choroid, and/or optic nerve head Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The severity of the uveitis The onset, duration and --AC cell grade course the uveitis A pt has dense AC cell, scantof anterior vitreous cell, and cystoid macular edema. Given all The location of the uveitis --Anterior --Intermediate three locations are involved, --Onset: this Sudden insidious yes? --AC flare grade pt hasvspanuveitis, --Vitreous score --Posterior Limited persistent No. The description --Duration: clearly suggests the vs pt has an anterior uveitis with haze spillover of cell into --Panuveitis vsmacular recurrent vs caused by the anterior uveitis. In the anterior vitreous, --Course: along with. Acute cystoid edema chronic other words, despite the fact that all three locations are involved, the primary location is anterior, making this an anterior uveitis. With respect to uveitis, where is the primary inflammation located in… Anterior uveitis? The anterior chamber (although cell ‘spillover’ into the anterior vitreous may occur) Intermediate uveitis? The vitreous, peripheral retina and/or pars plana Posterior uveitis? The retina and/or choroid Panuveitis? All three locations are equally involved

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score With respect to uveitis, what is the difference between… Sudden vs insidious onset? Sudden-onset uveitis presents with abrupt development of symptoms (pain, photophobia) and signs (injection); whereas insidious uveitis is largely sign- and symptom-free Limited and persistent duration? Limited lasts < 3 months; persistent > 3 months Acute, recurrent and chronic course? Acute uveitis comes on suddenly and resolves fairly quickly. Recurrent uveitis eventually relapses, but is quiescent off-treatment for at least 3 months. Chronic uveitis also relapses, but its quiescent periods off-treatment will last less than 3 months.

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score With respect to uveitis, what is the difference between… Sudden vs insidious onset? Sudden-onset uveitis presents with abrupt development of symptoms (pain, photophobia) and signs (injection); insidious uveitis is largely sign- and symptom-free Limited and persistent duration? Limited lasts < 3 months; persistent > 3 months Acute, recurrent and chronic course? Acute uveitis comes on suddenly and resolves fairly quickly. Recurrent uveitis eventually relapses, but is quiescent off-treatment for at least 3 months. Chronic uveitis also relapses, but its quiescent periods off-treatment will last less than 3 months.

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score With respect to uveitis, what is the difference between… Sudden vs insidious onset? Sudden-onset uveitis presents with abrupt development of symptoms (pain, photophobia) and signs (injection); insidious uveitis is largely sign- and symptom-free Limited vs persistent duration? Limited lasts < 3 months; persistent > 3 months Acute, recurrent and chronic course? Acute uveitis comes on suddenly and resolves fairly quickly. Recurrent uveitis eventually relapses, but is quiescent off-treatment for at least 3 months. Chronic uveitis also relapses, but its quiescent periods off-treatment will last less than 3 months.

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score With respect to uveitis, what is the difference between… Sudden vs insidious onset? Sudden-onset uveitis presents with abrupt development of symptoms (pain, photophobia) and signs (injection); insidious uveitis is largely sign- and symptom-free Limited vs persistent duration? Limited lasts < 3 months; persistent > 3 months Acute, recurrent vs chronic course? Acute uveitis comes on suddenly and resolves fairly quickly. Recurrent uveitis eventually relapses, but is quiescent off-treatment for at least 3 months. Chronic uveitis also relapses, but its quiescent periods off-treatment will last less than 3 months.

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score With respect to uveitis, what is the difference between… Sudden vs insidious onset? Sudden-onset uveitis presents with abrupt development of symptoms (pain, photophobia) and signs (injection); insidious uveitis is largely sign- and symptom-free Limited vs persistent duration? Limited lasts < 3 months; persistent > 3 months Acute, recurrent vs chronic course? Acute uveitis comes on suddenly and resolves fairly quickly. Recurrent uveitis eventually relapses, but is quiescent off-treatment for at least 3 months. Chronic uveitis also relapses, but its quiescent periods off-treatment last less than 3 months.

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score How is the severity of the AC cellular reaction graded? By counting the number of WBCs visible within a 1 x 1 mm slit-lamp beam What are the six grades employed in the SUN criteria, and how many cells/field correlate with each grade?

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score How is the severity of the AC cellular reaction graded? By counting the number of WBCs visible within a 1# xx # 1 mm slit-lamp beam What are the six grades employed in the SUN criteria, and how many cells/field correlate with each grade?

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score How is the severity of the AC cellular reaction graded? By counting the number of WBCs visible within a 1 x 1 mm slit-lamp beam What are the six grades employed in the SUN criteria, and how many cells/field correlate with each grade?

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? Grade Number of Cells/Field To standardize uveitis nomenclature ? ? ? --Anterior --Intermediate? --Posterior --Panuveitis ? ? The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis ? ? The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score How is the severity of the AC cellular reaction graded? By counting the number of WBCs visible within a 1 x 1 mm slit-lamp beam What are the six grades employed in the SUN criteria, and how many cells/field correlate with each grade?

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? Grade Number of Cells/Field To standardize uveitis nomenclature 0 <1 0. 5+ 1 -5 1+ 6 -15 The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate 2+ --Posterior --Panuveitis 3+ 4+ The onset, duration and course of the uveitis 16 -25 --Onset: Sudden vs insidious --Duration: Limited vs persistent 26 -50 --Course: Acute vs recurrent vs chronic >50 The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score How is the severity of the AC cellular reaction graded? By counting the number of WBCs visible within a 1 x 1 mm slit-lamp beam What are the six grades employed in the SUN criteria, and how many cells/field correlate with each grade?

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic In addition to location, onset/duration/course, and severity, what other aspects of presentation are important in classifying a case of uveitis? --Laterality (ie, whether it is univs bilateral) --The appearance of keratic precipitates (KP) --Iris changes The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic In addition to location, onset/duration/course, and severity, what other aspects of presentation are important in classifying a case of uveitis? --Laterality (ie, whether it is univs bilateral) --The character of keratic precipitates (KP) if present --Iris changes The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic In addition to location, onset/duration/course, and severity, what other aspects of presentation are important in classifying a case of uveitis? --Laterality (ie, whether it is univs bilateral) --The character of keratic precipitates (KP) if present --Iris changes Broadly, what two characteristics of KP are important? --Their appearance and their distribution The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score In addition to location, onset/duration/course, and severity, what other aspects of presentation are important in classifying a case of uveitis? --Laterality (ie, whether it is univs bilateral) The distribution of KP is most often --The character of keratic precipitates (KP) if present described with one of two terms. What --Iris changes Broadly, what two characteristics of KP are important? are they? --Their appearance and their distribution --Diffuse --Confined to Arlt’s triangle

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score In addition to location, onset/duration/course, and severity, what other aspects of presentation are important in classifying a case of uveitis? --Laterality (ie, whether it is univs bilateral) The distribution of KP is most often --The character of keratic precipitates (KP) if present described with one of two terms. What --Iris changes Broadly, what two characteristics of KP are important? are they? --Their appearance and their distribution --Diffuse twotriangle words --Confined to Arlt’s

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score In addition to location, onset/duration/course, and severity, what other aspects of presentation are important in classifying a case of uveitis? --Laterality (ie, whether it is univs bilateral) The distribution of KP is most often --The character of keratic precipitates (KP) if present described with one of two terms. What --Iris changes Broadly, what two characteristics of KP are important? are they? --Their appearance and their distribution --Diffuse --Confined to Arlt’s triangle

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis Where/what is and The onset, duration course of. Arlt’s the triangle? uveitis It’s a triangle with its --Onset: Sudden vs insidious apex at the corneal --Duration: Limited vs persistent center and base near --Course: Acute vs recurrent the inferior border of vs chronic the cornea The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score In addition to location, onset/duration/course, and severity, what other aspects of presentation are important in classifying a case of uveitis? --Laterality (ie, whether it is univs bilateral) The distribution of KP is most often --The character of keratic precipitates (KP) if present described with one of two terms. What --Iris changes Broadly, what two characteristics of KP are important? are they? --Their appearance and their distribution --Diffuse --Confined to Arlt’s triangle

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the Cornea International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature Arlt’s triangle The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis Where/what is and The onset, duration course of. Arlt’s the triangle? uveitis It’s a triangle with its --Onset: Sudden vs insidious apex at the corneal --Duration: Limited vs persistent center and base near --Course: Acute vs recurrent the inferior border of vs chronic the cornea The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score In addition to location, onset/duration/course, and severity, what other aspects of presentation are important in classifying a case of uveitis? --Laterality (ie, whether it is univs bilateral) The distribution of KP is most often --The character of keratic precipitates (KP) if present described with one of two terms. What --Iris changes Broadly, what two characteristics of KP are important? are they? --Their appearance and their distribution --Diffuse --Confined to Arlt’s triangle

Uveitis: Classification Diffusely distributed KP KP concentrated in Arlt’s triangle 114

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score In addition to location, onset/duration/course, and severity, what other aspects of presentation are important in classifying a case of uveitis? --Laterality (ie, whether it is univs bilateral) The appearance of KP is most often described --The character of keratic precipitates (KP) if present with one of three terms. What are they? --Iris changes Broadly, what two characteristics of KP are important? --Their appearance and their distribution --?

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score In addition to location, onset/duration/course, and severity, what other aspects of presentation are important in classifying a case of uveitis? --Laterality (ie, whether it is univs bilateral) The appearance of KP is most often described --The character of keratic precipitates (KP) if present with one of three terms. What are they? --Iris changes Broadly, what two characteristics of KP are important? --Granulomatous --Their appearance and their distribution --Nongranulomatous --Stellate

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score It can be tough to distinguish between nongranulomatous and stellate KP. Here is another In addition to location, onset/duration/course, and severity, what other distinguishing characteristic: : aspects of presentation are important in classifying a case of uveitis? --Laterality (ie, whether it is univs bilateral) The appearance of KP is most often described --The character of keratic precipitates (KP) if present with one of three terms. What are they? --Iris changes Broadly, what two characteristics of KP are important? --Granulomatous Always… --Their appearance and their distribution --Nongranulomatous Always… --Stellate

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score It can be tough to distinguish between nongranulomatous and stellate KP. Here is another In addition to location, onset/duration/course, and severity, what other distinguishing characteristic: : aspects of presentation are important in classifying a case of uveitis? --Laterality (ie, whether it is univs bilateral) The appearance of KP is most often described --The character of keratic precipitates (KP) if present with one of three terms. What are they? --Iris changes Broadly, what two characteristics of KP are important? --Granulomatous Always…in Arlt’s triangle --Their appearance and their distribution --Nongranulomatous Always…diffuse --Stellate

119 Uveitis: Classification Stellate KP Granulomatous KP

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic In addition to location, onset/duration/course, and severity, what other aspects of presentation are important in classifying a case of uveitis? --Laterality (ie, whether is uni-sorts vs bilateral) Broadly, it what of iris changes must be looked for? --The character of keratic precipitates (KP) if present --Atrophy --Iris changes --Synechiae --Nodules --Heterochromia The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score In addition to location, onset/duration/course, and severity, what other aspects of presentation are important in classifying a case of uveitis? The of atrophic changes is often described with one of --Laterality (ie, whether is univs character bilateral) Broadly, it what sorts of iris changes must be looked for? two terms. What are they? --The character of keratic precipitates (KP) if present --Atrophy --Iris changes --Synechiae --Diffuse --Sectoral --Nodules --Heterochromia

Uveitis: Classification Diffuse Sectoral Iris atrophy

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score In addition to location, onset/duration/course, and severity, what other aspects of presentation are important in classifying a case of uveitis? --Laterality (ie, whether is uni-sorts vs bilateral) Broadly, it what of iris changes must be looked for? --The character of keratic precipitates (KP) if present Synechiae typically are found in one of two locations--where? --Atrophy --Iris changes --Synechiae ---At the angle (these are called peripheral anterior synechiae--PAS) --Nodules --Heterochromia

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score In addition to location, onset/duration/course, and severity, what other aspects of presentation are important in classifying a case of uveitis? --Laterality (ie, whether is uni-sorts vs bilateral) Broadly, it what of iris changes must be looked for? --The character of keratic precipitates (KP) if present Synechiae typically are found in one of two locations--where? --Atrophy --Iris changes --Synechiae --At the pupillary margin (these are called posterior synechiae) --At the angle (these are called peripheral anterior synechiae) --Nodules --Heterochromia

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score In addition to location, onset/duration/course, and severity, what other aspects of presentation are important in classifying a case of uveitis? --Laterality (ie, whether is uni-sorts vs bilateral) Broadly, it what of iris changes must be looked for? --The character of keratic precipitates (KP) if present Synechiae typically are found in one of two locations--where? --Atrophy --Iris changes --Synechiae --At the pupillary margin (these are called posterior synechiae) two words --At the angle (these are called peripheral anterior synechiae) --Nodules --Heterochromia

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score In addition to location, onset/duration/course, and severity, what other aspects of presentation are important in classifying a case of uveitis? --Laterality (ie, whether is uni-sorts vs bilateral) Broadly, it what of iris changes must be looked for? --The character of keratic precipitates (KP) if present Synechiae typically are found in one of two locations--where? --Atrophy --Iris changes --Synechiae --At the pupillary margin (these are called posterior synechiae) --At the angle (these are called peripheral anterior synechiae) --Nodules --Heterochromia

Uveitis: Classification Posterior Peripheral anterior Iris synechiae

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score In addition to location, onset/duration/course, and severity, what other aspects of presentation are important in classifying a case of uveitis? --Laterality (ie, whether is uni-sorts vs bilateral) Broadly, it what of iris changes must be looked for? --The character of keratic precipitates (KP)typically if present Iris nodules are found in one of three locations--where? --Atrophy --Iris changes --Synechiae ---Nodules ----Heterochromia

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score In addition to location, onset/duration/course, and severity, what other aspects of presentation are important in classifying a case of uveitis? --Laterality (ie, whether is uni-sorts vs bilateral) Broadly, it what of iris changes must be looked for? --The character of keratic precipitates (KP)typically if present Iris nodules are found in one of three locations--where? --Atrophy --Iris changes --Synechiae --At the pupillary margin --Nodules --The mid-iris --At the angle --Heterochromia

Uveitis: Classification Marginal Mid-iris Iris nodules Near the angle

Uveitis: Classification 1) The uveitis is profiled 2) The profiled case is meshed 3) A differential diagnosis list is generated 4) Studies are obtained to identify the etiology 5) Treatment appropriate for the etiology is initiated In the context of uveitis, what does the acronym SUN stand for? Standardization of Uveitis Nomenclature, a working group appointed by the International Ocular Inflammation Society What was the task of the SUN Working Group? To standardize uveitis nomenclature The SUN classification system is based on three sets of criteria. What are they? The location of the uveitis --Anterior --Intermediate --Posterior --Panuveitis The onset, duration and course of the uveitis --Onset: Sudden vs insidious --Duration: Limited vs persistent --Course: Acute vs recurrent vs chronic The severity of the uveitis --AC cell grade --AC flare grade --Vitreous haze score In addition to location, onset/duration/course, and severity, what other aspects of presentation are important in classifying a case of uveitis? --Laterality (ie, whether is univs of bilateral) Broadly, itwhat sorts iris changes must be looked for? --The character of keratic precipitates (KP) if present --Atrophy --Iris changes --Synechiae In a pt with uveitis and heterochromia, which iris is more --Nodules likely to be the abnormal one--the lighter iris, or the darker? --Heterochromia The lighter

Uveitis: Classification Heterochromia iridis in a uveitis pt 136