UVA Research Administrators Meeting Karen C Johnston coDirector

UVA Research Administrators Meeting Karen C. Johnston, co-Director – THRIV, i. THRIV Sandra G. Burks, Program Director – THRIV, i. THRIV September, 2018

Agenda Foundational THRIV i. THRIV Overview CTSA proposal updates i. THRIV Impact on the research community i. THRIV Education / training Workforce KL 2 development

THRIV Translational Health Research Institute of Virginia Using data to improve health Foundational program at UVA Cross-Grounds initiative supported primarily by SOM Focus-integration research Collaborative of data science w/clinical/trans research infrastructure support Collaborative education/training

integrated THRIV Leadership Cross-state research team UL 1 Principal Investigators Karen CTSA proposal C. Johnston, MD, MSc Donald Partner John E. Brown, Ph. D Site Leadership Warren KL 2 Bickel, Ph. D (VTC) Niederhuber, MD (Inova) Leadership Bradford Jason Council: B. Worrall, MD A. Papin, Ph. D Affiliate Leadership: COS: Brian Nosek LVG: Michael Straightiff

i. THRIV Vision Integrated Connects research community across geography and discipline Establishes Promotes Major technical and sociological frameworks team science challenges: Chasm between data scientist and clinical translational researchers Chasm between patient communities and clinical scientists

Using Data to Improve Health Integrated communities – using data and informatics systems Leverages and builds on existing local and cross-state infrastructures i. THRIV footprint covers ~60% population in Virginia Allow connection across geography and discipline Significant emphasis on community engagement

NIH Clinical & Translational Science Awards “CTSA”-funded Premier by NIH-NCATS since 2006 clinical and translational research sites in US Innovative programs to turn scientific observations into interventions that improve the health of the public ~60 sites funded (UVA has never been funded) Traditional Our CTSA funds ~40% of program costs innovative program relates to data science/informatics

Required Core Components of the CTSA Administrative Core Informatics Community and Collaboration Translational Research Hub Endeavors Methods Research Capacity Network Capacity Institutional Career Development Core (KL 2)

CTSA Timeline Submission: January 2018 Review: June 2018 - Score 21(negligible weaknesses) Council: September 27, 2018 Anticipated CTSA NOA: January 2019 budget proposal (5 years): CTSA Budget (Directs) $15, 564, 505 (including partner site directs) UVA Total (direct + indirect) CTSA Budget (Directs + Indirects) $14, 583, 506 $22, 964, 056 **CTSA funds expected to cover ~ 40% of total anticipated costs for program

How do THRIV and i. THRIV add value for the research community? Combines human and technologic support Builds community engagement Fosters team science

Human and Technologic Support Integrates and optimizes existing research services Includes services at partner and affiliate sites Developing shared tools and resources

Human and Technologic Support Cross state shared technological/data infrastructure Personalized access to data, tools, resources Harmonized across partner sites Epic EHR I 2 b 2/OMOP/Tri. Net. X/SHRINE Red. Cap, Music, On. Core Casis (biorepository) Ivy/Rivanna Elements/VIVO Others

Research Concierge Portal Phase I Implement a Virtual Map of Translational health Resources Across i. THRIV Institutions Orient investigators to research topics, tools, and resources Promote resource sharing and collaboration Demonstrate our joint identity and diverse expertise Introduce i. THRIV services (T-RECS, BERD, RKS, studios) and tools (Tri. Net. X, VIVO, etc. ) Build connection between researchers and the communities we serve (education, study recruitment, dissemination of results) Johanna Loomba – i. THRIV Research Concierge Services Manager

FIND RESOURCES INTERFACE

Community Engagement Build community relationships Train research teams Reduce barriers to research participation Increase special populations in trials Expand community based participatory research i. THRIV Community Engagement Advisory Boards Dedicated i. THRIV Partnership Manager (Kristin Miller)

Team Science: Seed Grants First round – UVA/Inova Collaboration Awards (2017 -2018) 8 funded projects Co-PIs UVA and Inova faculty Several 1 abstracts presented grant submitted Manuscripts Future CTSA in preparation seed grants both internal and via

Team Science: THRIV/i. THRIV Studios Moderated forum to share expertise, foster team science, promote excellence CTSA/Vanderbilt University model i. THRIV Studio Lead: Jaideep Kapur Studio Manager: Johanna Loomba Initial Programs at UVA Brain Institute THRIV scholars K to R transition Opportunities: All i. THRIV sponsored seed grants Other….

i. THRIV Education and Training: i. THRIV mission includes commitment to growing the next generation of clinical translational researchers. Workforce development KL 2/THRIV Scholars

Education and Training: Workforce Development Developing efficiencies for training and supporting research teams Core competencies for clinical translational research CRC Best education practices for research process

Education and Training: THRIV / i. THRIV KL 2 Scholars Junior faculty mentored career development program THRIV Scholars – internally funded UVA program THRIV Scholars: Foundational for proposed i. THRIV KL 2 program VT Scholars: developing program i. THRIV KL 2 to integrate VTC & Inova faculty

THRIV / i. THRIV KL 2 Scholars Jason Papin, Ph. D Bradford Worrall, MD, MSc

2017 -2019 UVA THRIV Scholars Scholar Jessica Keim-Malpass, Ph. D, RN, Acute & Specialty Care, SON Research Proposal Primary Mentor A pragmatic clinical trial J. Randall Moorman, MD evaluating impact of continuous predictive monitoring on nursedriven outcomes in a dynamic intensive care setting. Kyle J. Lampe, Ph. D, Chemical Engineering, SEAS Bioengineered hydrogels to facilitate 3 D neural stem cell survival and growth in a stroke environment. Kathleen Mc. Manus, MD, MS, Infectious Disease, SOM Affordable care act's effects on Rebecca Dillingham, MD, MPH persons living with HIV (PLWH) in Virginia. Brynne Sullivan, MD, Pediatrics, SOM Pulse oximetry cardiorespiratory scores to predict adverse events and outcomes in premature infants. Dustin Walters, MD, Surgery, SOM The role of CD 8+ TCell Sasha Krupnick MD mediated tolerance in non-small cell lung cancer. Brad Worrall, MD J. Randall Moorman, MD

2018 -2020 UVA THRIV Scholars THRIV Scholar J. Nicholas Brenton, MD, Neurology and Pediatrics, SOM Research Proposal Application of a ketogenic diet in relapsing-remitting multiple sclerosis Primary Mentor Karen Johnston, MD, MSc Myla Goldman, MD, MSc Meghan Mattos, Ph. D, RN, CNL, Acute-Specialty Care, SON Use of an internet-based intervention to prevent cognitive decline in older adults with mild cognitive impairment Predicting injury risk after motor vehicle collision using occupant / vehicle telemetry data Lee Ritterband, Ph. D, Carol Manning, Ph. D Computational modeling of intestinal mucosa: image analysis and multiomics Sean Moore, MD Thomas Hartka, MD, MS, Emergency Medicine, SOM Sana Syed, MBBS, MS, Pediatrics, SOM Neuro. Next Scholar (1 year) Andrew Schomer, MD, Neurology, SOM Primary Mentor Jaideep Kapur, MBBS, Ph. D Mark Sochor, MD

i. THRIV cross state team