Utilizing Ne SSI for Analytical Applications New SamplingSensor

Utilizing Ne. SSI™ for Analytical Applications New Sampling/Sensor Initiative (Ne. SSI™) Dave Veltkamp, CPAC

Overview of Talk Describe the features of Ne. SSI™ most likely to impact lab applications Discuss how Ne. SSI™ can facilitate laboratory applications and how current development fits lab needs Outline some outside proposals recently written to help fund Ne. SSI™ development & demonstration Mention some web-based resources at CPAC

What does Ne. SSI™ Provide Simple “Lego-like” assembly Easy to re-configure No special tools or skills required Standardized flow components “Mix-and-match” compatibility between vendors Growing list of components Standardized electrical and communication (soon) “Plug-and-play” integration of multiple devices Simplified interface for programmatic I/O and control Advanced analytics and measurement environment Mini or Micro-analyzers Integrated analysis or “smart” systems Expose students to “Industrial” techniques & needs

Ne. SSI™: Enabler for Micro. Analytical (the “rail” concept) Standard “connectivity” Standard Electrical (Digital) Interface “Rail” Anyone’s Sensor P Anyone’s Actuator V Standard Mechanical Interface “Rail” *Sensor/Actuator Manager SAM* Standard “hockey-puck PC”

How Does Ne. SSI™ Fit in the Lab Instrument/Sensor Interfaces Design standards make development simpler n n Reduced toolset to be mastered Reduced sample variability to account for Calibration/validation built-in n n Consistent physical environment for measurement Stream switching and/or mixing allow generation of standards to match analytical requirements Reaction monitoring Microreactors and continuous flow reactors Batch reactors (with fast loop) Sample Preparation Gas handling (mixing, generation, delivery) Liquid handling (mixing, dilution, conditioning, etc. )

Special Lab Ne. SSI™ Requirements Flowing streams Need to move liquid and gas streams through Ne. SSI™ Most laboratory analysis involves discrete samples rather than sample streams Analytical characterization of flow in Ne. SSI™ needed Heating and Cooling Laboratory applications need both May require more rapid thermal response Integration with other lab apparatus Serial communication most common Integration with lab software systems Low cost Competing with other solutions that don’t carry some of Ne. SSI’s more exotic features

Recent proposals featuring Ne. SSI™ NSF Instrumentation for Materials Research (IMR) Involves Ne. SSI™ and Microreactors to elucidate reaction kinetics and mechanisms for polymer modification chemistry Builds on previous CPAC concepts for Ne. SSI™ as fluidic delivery AND analysis platform for microreactors Includes development and testing of Synovec’s μ -MMS in Ne. SSI™ 3 years, $718 K

Ne. SSI™ Proposals (cont. ) NSF Chemistry Research Instrumentation and Facilities: Instrument Development (CRIF-ID) Provides basic research and testing to characterize Ne. SSI™ flows and develop needed support sub-systems for utilizing Ne. SSI™ in laboratory applications Funding to develop 3 (gas, liquid, and student lab) demonstration Ne. SSI™ systems 3 years, $642 K

Ne. SSI™ Proposals (cont. ) NSF Sensors and Sensor Networks Involves using Ne. SSI™ as a platform for characterizing vapochromatic compounds and development of gas phase sensors 2 identical Ne. SSI™ systems at UW and UM 3 years, $612 K Washington Technology Center (WTC) Development of prototype sensor/actuator manager (SAM) Collaborative effort with Infometrix Phase I, 6 months, $40 K

Ne. SSI™ Fermentation System Switching filter system to handle particulate laden liquid streams Cells in fermentation broth Supplied by Bob Sherman, Circor Interested in plugging, cleaning, and other issues related to bio/pharma applications 2 Filters

Circor Ferm. I Filter System

Building Automated Ne. SSI™ Swagelok provided 5 pneumatic valves, flow components and pressure transducers Parker providing solenoid pilot valve manifold for actuating pneumatic valves Brooks (Emerson) provided MFC’s and electronics Honeywell providing funds for data I/O and control system Thanks to all these contributions, we are very close to having an automated Ne. SSI™ system

Current CPAC Ne. SSI™ system

Ne. SSI™ Knowledge Network Main topic page divided into 4 sections News and Information Discussion (Ne. SSI Q&A) Component List n Only Manufacturers group may post here Testing and Examples Main Ne. SSI™ web site http: //www. cpac. washington. edu/Ne. SSI. htm NKN can be found at http: //www. cpac. washington. edu/Ne. SSI/NKN. html

Component List Sub-topics Page shown from the “Valve, Manual” topic Listing of topics under manual valve main topic Number of posts will correspond to different available components

Component List Page Example post from the component list page URL from Vendor Spec. sheet or link Picture, description, or link to more information Other Vendors are currently working to populate the list with more components

Component List Page

User Self-Registration Allows users to setup accounts Selecting to join “Manufacturers” group will queue user’s registration until a moderator approves it. Membership in other groups automatically approved immediately Profile data will be used for Ne. SSI™ mailing list Check the options available from the “Edit Profile” link once user activates account Once user submits registration form, they are sent an email with instructions for activating their new account Your account is not active till you log in and follow the instructions in the email

NKN Conclusion New software and web site ready to be used Thanks to Michelle Cohn, UOP for helping CPAC buy a new server to host Ne. SSI™ and NKN web sites Site functions well on the new server – much easier to use for both posting and browsing Ne. SSI Component List is becoming populated Major manufacturers (Parker, Circor, Swagelok) already signed up and starting to supply content Still need to get smaller suppliers to do the same Need to get user community to register and start using it

Ne. SSI™ Sensor Survey The purpose of this survey is to gather information on the sensors and actuators needed for Ne. SSI Sample Systems, Analytical Systems, and Cluster Applications. This data will be shared with sensor and instrument vendors to help them prioritize development of the devices needed across industries and applications. The more information you can provide, the faster better products and performance can be delivered

Ne. SSI™ Sensor Survey (cont. ) On-line survey form on the CPAC Ne. SSI™ web site http: //www. cpac. washington. edu/Ne. SSI/CPAC_Ne. SSI_ Sensor_Survey. htm Questions about condition sensors Are you interested How would you rank their importance Operating ranges Questions about analytical sensors Are you interested How would you rank their importance Operating ranges Questions about actuators Questions about “Clusters” Optional contact information

Sample Survey Questions

Ne. SSI™ Sensor Survey Results Condition Sensors Analytical Sensors

Ne. SSI™ Sensor Survey Results Actuators Clusters 14 of the 21 respondents indicated they would share information with Vendors

Ne. SSI™ Sensor Survey (cont. ) Plan is to continue to solicit responses from users Additions to survey questions or content welcome May expand survey activities to help provide market directions to suppliers Other aspects of Ne. SSI™ development n n Applet Software and other issues relate to SAM New opportunities or innovations Need to reach beyond the normal Ne. SSI™ enthusiasts Combined with the discussion board, surveys provide a valuable resource for both end-users and manufacturers of Ne. SSI

Summary & Conclusion Automated Ne. SSI™ ready for development Working spec/prototype design complete Prototypes demonstrated in real applications Resolution of the Ne. SSI™ bus issue For some laboratory applications Components and systems currently available will immediately work and provide benefits For other applications New components/architecture will be needed to “fit” current lab practices The future holds a lot of promise!!