Utilizing Ne SSI for Analytical Applications Brian Marquardt
Utilizing Ne. SSI™ for Analytical Applications Brian Marquardt Dave Veltkamp Center for Process Analytical Chemistry (CPAC) University of Washington, Seattle, WA
Project Overview Goal is to support Ne. SSI™ related development within CPAC Developing infrastructure and platforms Developing sensors and applications Promote and support wider Ne. SSI™ adoption and use Web based support Interaction with Ne. SSI community
What does Ne. SSI™ Provide Simple “Lego®-like ” assembly (√) Easy to re-configure No special tools or skills required Overall lower cost of build – reduce time to configure/install by 75% Improved reliability Lower cost of ownership – reduce total cost by 40% Standardized flow components (√) “Mix-and-match” compatibility between vendors Growing list of components Standardized electrical and communication (+) “Plug-and-play” integration of multiple devices Simplified interface for programmatic I/O and control Advanced analytics (+) Micro-analyzers Integrated analysis or “smart” systems √ now + soon
The Ne. SSI™ “rail” Concept Standard “connectivity” Enabler for Micro Analytical Standard Electrical (Digital) Interface “Rail” Ne. SSI™ Bus Anyone’s Sensor P Anyone’s Actuator V SAM* Standard “Applets” *Sensor/Actuator Manager ISA/ANSI SP 76 Standard Mechanical Interface “Rail” Opportunities exist to exploit Ne. SSI™ standards in other laboratory applications
Ne. SSI™ Sensing Technologies Chromatography Thermal Desorption (? ) GC (+) LC (chip based) (+) SEC, IC (? ) Dielectric (√) Spectroscopies IR (+), NIR (+) UV- Vis (+) Raman (√) Fluorescence (+) Refractive Index (√) Vapochromic Sensors (+) GLRS (+) Particle Sizing Light scattering (? ) Conductivity (√) Turbidity (+) p. H (√) SPR (+) Mass Spectrometry (√) Impedance (+) Terrahertz (? ), NMR (? ) √ now + soon ? maybe
Where Does Ne. SSI™ Fit in the Lab Instrument/Sensor Interfaces Design standards make development simpler Simplified design, construction, and reconfiguration Reduced sample variability to account for Calibration/validation built-in Consistent physical environment for measurement Stream switching and/or mixing allow generation of standards to match analytical requirements Bridge to micro analytical developments Reaction monitoring Microreactors and continuous flow reactors Batch reactors (with fast loop) Sample Preparation Gas handling (mixing, generation, delivery) Liquid handling (mixing, dilution, conditioning, etc. )
Agilent Ne. SSI™ Dielectric Sensor Cable to Agilent Network Analyzer Dielectric Probe Close up of Coaxial Probe Tip Inner Body O-ring (inside) Swagelok 2 -Port Valve Base Outer Body Exploded View
Vapochromic Sensor Interface Optical sensor based on vapochromatic compounds Responds to different analytes by intensity and wavelength shifts in fluorescence signal Optical detection using simple spectrometer LED excitation light source Simple reflectance 2 fiber optical measurement Use of Ball. Probe™ to provide single-sided optical interface Vapochrome coated on ball surface Inserted into standard Ne. SSI™ tube fitting block Ne. SSI™ system provides controlled delivery and mixing of gas streams to sensor
Ne. SSI™ Gas Mixing System Using a customized Ballprobe™ reflectance probe for vapochromic detection Swagelok Ne. SSI™ system Brooks MFC’s and controller Ocean optics USB VIS spectrometer Ballprobe™ coated with vapochrome
Vapochromic O 2 Sensor Response
New Gas Sensor Testing System More capability to generate analytical vapors, gas blending, and on-line dilution of vapor streams for method development work Vapor generation initially off-system – research opportunity for integrating onto Ne. SSI™ platform Serial dilution possibilities allows wide concentration range to be investigated
Ne. SSI Raman Sampling Block Parker Intraflow Ne. SSI substrate Sample conditioning to induce backpressure to reduce bubble formation and the heated substrate allows analysis at reactor conditions
Ne. SSI™ Microreactor Delivery /Calibration System Pump 1 Reactor Feed 1 Product Stream Reactor Feed 2 Real-time Calibration waste prod Pump 2 Raman Probe
IMM Microreactors and Micro. Mixers Liquid Microreactor Micro Mixer Heat Exchanger Mixer-Heat Exchanger Caterpillar Mixer Backbone Block Ne. SSI™ Adapter
Fuel Cell Research Goal: to study the water uptake properties of Nafion 112 by varying the relative humidity of the input gas streams to better understand membrane hydration and its effects on fuel cell performance. Ne. SSI™ System for gas flow and humidity sensing H 2 in 3 Voltmeters, 1 Ammeter Thermocouple and Humidity sensors PEM Fuel Cell Both Streams Purge to outside environment Air in Fan/Blower Or Pump Tank (might run system without a tank)
Where Are We Now? Development continues on control system Data I/O, comm. , and control hardware Software for DAQ, automation and control Ne. SSI microreactor system becoming reality Parker Intraflow™ fluidic system designed and being built IMM, Microglass, CPC mixers and reactor components here or coming soon LC, Raman, dielectric, RI detection demonstrated or close to Headspace and media sampling systems RGA analyzer, Thermo MS systems running Filter system from CIRCOR functionally tested Vapochromatic sensor test and development platform operational and providing good results Large improvement over traditional lab gas handling systems Ne. SSI™ flexibility allows for evolutionary improvements
What’s Ahead Continue gas sensing work with focus on application development Vapochromatic BTEX sensor (array) Vapochromatic humidity sensor fuel cells Fermentation headspace/off-gas monitoring Continue development of control and acquisition software Begin characterizing flows and dispersion in the Ne. SSI™ systems Important for analytical and mixing applications Continue developing analytical interfaces to bring more instrumentation to Ne. SSI™ Working with Vendors of new technology In-house fiber optic flow cell for Ne. SSI™
Acknowledgements Swagelok, CIRCOR, and Parker (Ne. SSI™ systems and components) Brooks Instruments and Flowmatrix (MFCs) Thermo and Merk/Horiba (Mass Spec. ) Agilent (Dielectric) IMM, Microglass, and CPC (microreactors) UOP (server for Ne. SSI™ web sites) Exxon. Mobil, Kraft, others (applications) Ne. SSI™ Steering Team CPAC
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