Uterine Cancer Endometrial or uterine cancer will account

Uterine Cancer • Endometrial (or uterine) cancer will account for 50, 000 new cases and 8200 deaths in the United States in 2013. • Two genetic disorders are associated with abnormal genes – Lynch syndrome and Cowden syndrome. Lynch syndrome accounts for 2% of all uterine cancers. • In Lynch syndrome the risk of uterine cancer by age 70 is 50% (range 25% to 60%) compared to 2. 7% for the general population. • Average of onset is 48 • Like colon cancer patients with Lynch, women with Lynch and endometrial cancer have a better prognosis.

• The second disorder is Cowden Syndrome. • This is a mutation in the p. TEN protein, which is one of the proteins responsible for regulating cell growth. • Clinically, Cowden is not one finding but a constellation of factors that increase the chance of finding this altered gene. • The following is the consensus criteria for the diagnosis:

• To check for Cowden syndrome, you will be assessed to see if you meet criteria for a research study offered by the Cleveland Clinic. • If you meet criteria, the Cleveland Clinic has a grant to look for p. TEN mutations. • The test is also available through reference labs.

• Beyond these two syndromes there are other conditions that can increase your chances for uterine cancer. • Call for an appointment so we can discuss your family history and whether you might be a carrier of one of these genes.