Urokinase Plasminogen Activator u PA and its Receptor

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Urokinase Plasminogen Activator (u. PA) and its Receptor u. PAR

Urokinase Plasminogen Activator (u. PA) and its Receptor u. PAR

The Importance of Cell Movements In Development Early embryogenesis Organ & tissue development Organ

The Importance of Cell Movements In Development Early embryogenesis Organ & tissue development Organ & tissue remodeling throughout life In defense & disease Immune responses Wound healing Invasion & metastasis

Hepatacyte Growth Factor (HGF) is a Powerful Inducer of Epithelial Cell Motility Figure 14.

Hepatacyte Growth Factor (HGF) is a Powerful Inducer of Epithelial Cell Motility Figure 14. 24 The Biology of Cancer (© Garland Science 2007)

EGF Secreted by Mθs Induces Motility in Breast Carcinoma Cells Recall: Figure 14. 23

EGF Secreted by Mθs Induces Motility in Breast Carcinoma Cells Recall: Figure 14. 23 b The Biology of Cancer (© Garland Science 2007)

Rho Family Small G Proteins Play Central Roles in Cell Motility and Invasiness Rac,

Rho Family Small G Proteins Play Central Roles in Cell Motility and Invasiness Rac, Cdc 42, Rho and their GEFs (eg Tiam 1 Rac) are all involved in the orchestration of extension/sensing/contraction and MMP secretion that are involved in the movement of cells across surfaces. A role for Rho proteins is demonstrated by studies of melanoma. filopodium

The Lymphatic System

The Lymphatic System

Draining Lymph Nodes Can be Destinations for Metastatic Cells Metastasis to draining lymph node

Draining Lymph Nodes Can be Destinations for Metastatic Cells Metastasis to draining lymph node Figure 14. 41 a The Biology of Cancer (© Garland Science 2007)

The ‘Seed and Soil’ Principle – Some Tissues are More Susceptible to Colonization by

The ‘Seed and Soil’ Principle – Some Tissues are More Susceptible to Colonization by Particular Tumors Than Others Figure 14. 42 The Biology of Cancer (© Garland Science 2007)

Figure 14. 44 The Biology of Cancer (© Garland Science 2007)

Figure 14. 44 The Biology of Cancer (© Garland Science 2007)

Breast Cancer Tends to be Osteolytic & Prostate Cancer Tends to be Osteoblastic Figure

Breast Cancer Tends to be Osteolytic & Prostate Cancer Tends to be Osteoblastic Figure 14. 46 The Biology of Cancer (© Garland Science 2007)

The Osteoblastic Cascade Figure 14. 48 The Biology of Cancer (© Garland Science 2007)

The Osteoblastic Cascade Figure 14. 48 The Biology of Cancer (© Garland Science 2007)

Table 14. 4 The Biology of Cancer (© Garland Science 2007)

Table 14. 4 The Biology of Cancer (© Garland Science 2007)

Cytokeratin-free Bone Marrow Augurs Well Figure 14. 50 a The Biology of Cancer (©

Cytokeratin-free Bone Marrow Augurs Well Figure 14. 50 a The Biology of Cancer (© Garland Science 2007)

Gene Expression Signatures Show Some Promise as Prognostic Indicators Figure 14. 51 a The

Gene Expression Signatures Show Some Promise as Prognostic Indicators Figure 14. 51 a The Biology of Cancer (© Garland Science 2007)

Instigators & Responders – Implications for Micrometastases Mc. Callister et al. , Cell 133:

Instigators & Responders – Implications for Micrometastases Mc. Callister et al. , Cell 133: 994 (2008)

Figure 14. 53 The Biology of Cancer (© Garland Science 2007)

Figure 14. 53 The Biology of Cancer (© Garland Science 2007)

Plasminogen Activator Inhibitor1 Reduces TissueType Plasminogen Activator DependentPlasminogen Activator Inhibitor1 Reduces TissueType Plasminogen Activator Dependent
Plasminogen activators tPA uPA Plasminogen activator inhibitors PAIPlasminogen activators tPA uPA Plasminogen activator inhibitors PAI
Specific Interference of Urokinasetype Plasminogen Activator Receptor andSpecific Interference of Urokinasetype Plasminogen Activator Receptor and
UVB Increases UrokinaseType Plasminogen Activator Receptor u PARUVB Increases UrokinaseType Plasminogen Activator Receptor u PAR
Prothrombinase Components Can Accelerate Tissue Plasminogen Activatorcatalyzed PlasminogenProthrombinase Components Can Accelerate Tissue Plasminogen Activatorcatalyzed Plasminogen
Recombinant Toxins That Bind to the Urokinase ReceptorRecombinant Toxins That Bind to the Urokinase Receptor
Circulating Fibronectin and Plasminogen Activator Inhibitor2 Levels asCirculating Fibronectin and Plasminogen Activator Inhibitor2 Levels as
Synergistic and Multidimensional Regulation of Plasminogen Activator InhibitorSynergistic and Multidimensional Regulation of Plasminogen Activator Inhibitor
Plasminogen Activator Inhibitor1 Levels and Activity Decrease AfterPlasminogen Activator Inhibitor1 Levels and Activity Decrease After
Increased Plasminogen Activator Inhibitor1 in Keloid Fibroblasts MayIncreased Plasminogen Activator Inhibitor1 in Keloid Fibroblasts May
Rice paper cont TPA Tissue plasminogen activator dissolvesRice paper cont TPA Tissue plasminogen activator dissolves
A Noncanonical Role for Plasminogen Activator Inhibitor TypeA Noncanonical Role for Plasminogen Activator Inhibitor Type
Tissue Plasminogen Activator for Acute Ischemic Stroke NationalTissue Plasminogen Activator for Acute Ischemic Stroke National
Dual Role for Plasminogen Activator Inhibitor Type 1Dual Role for Plasminogen Activator Inhibitor Type 1
Tissuetype Plasminogen Activator Acts as a Cytokine ThatTissuetype Plasminogen Activator Acts as a Cytokine That