Upregulation of homeodomain genes DLX 1 and DLX
- Slides: 7
Up-regulation of homeodomain genes, DLX 1 and DLX 2, by FLT 3 signaling by Julia Starkova, Sharvari Gadgil, Yi Hua Qiu, Nianxiang Zhang, Ivana Hermanova, Steven M. Kornblau, and Harry A. Drabkin haematol Volume 96(6): 820 -828 June 1, 2011 © 2011 by Ferrata Storti Foundation
Effect of PKC 412 on DLX 1 and DLX 2 gene expression (A). Julia Starkova et al. Haematologica 2011; 96: 820 -828 © 2011 by Ferrata Storti Foundation
DLX 1 expression in samples from AML patients and effect of PKC 42 ex vivo (A) Box plots showing results of RPPA analysis in AML patients characterized according to FLT 3 status (NEG – FLT 3 wt; POS – FLT 3/ITD) using the ANOVA test (B) Box plot illustrating the. . . Julia Starkova et al. Haematologica 2011; 96: 820 -828 © 2011 by Ferrata Storti Foundation
Expression of p 15, CUTL-1 and PAI-1 genes (A) Graphs show fold-change of p 15, CUTL-1 and PAI-1 gene expression in MV 4; 11 cells after PKC 412 (0. 1 μM) and TGFβ 1 (1, 2, 3, 5 ng/m. L) treatment, alone or in combination, normalized to untreated control cells and t. . . Julia Starkova et al. Haematologica 2011; 96: 820 -828 © 2011 by Ferrata Storti Foundation
Knockdown of DLX 1 (si. DLX 1) alters response to TGFβ 1 and FLT 3 ligand. Julia Starkova et al. Haematologica 2011; 96: 820 -828 © 2011 by Ferrata Storti Foundation
Cytostatic effect of PKC 412, TGFβ 1 and their combination. Julia Starkova et al. Haematologica 2011; 96: 820 -828 © 2011 by Ferrata Storti Foundation
Effect of PKC 412 on phosphorylation of Smad 2. Julia Starkova et al. Haematologica 2011; 96: 820 -828 © 2011 by Ferrata Storti Foundation
