Understanding the Intersection Between Information Technology and the
Understanding the Intersection Between Information Technology and the Life Sciences The Terrain Bob Royce VP Business Development Bio-IT Workshop: Positioning Your Firm. January 21, 2003
I want to conquer death! I don’t want to be sick! Bio-IT Workshop: Positioning Your Firm. January 21, 2003
What is Bio-IT? Information Technology Life Sciences Bio-IT Workshop: Positioning Your Firm. January 21, 2003
“Biology is an information science” Leroy Hood, Michigan Life Science Core Technology Alliance Inauguration In vivo silico Bio-IT Workshop: Positioning Your Firm. January 21, 2003
“ the language of biology is sounding increasingly like the language of systems engineering ” MIT President Chuck Vest 103 of 341 MIT engineering school faculty use the term “bio” to describe the nature of their research. Systems Biology at MIT: It’s All Over the Place By Adrienne Burke, Genome Technology editor-in-chief CAMBRIDGE, Mass. , Jan. 9 Bio-IT Workshop: Positioning Your Firm. January 21, 2003
Biological Information Genotype -> Phenotype DNA Biological Function Scientific Process Information Hypothesis -> Experiment Design Analysis Optimization/ Archive Bio-IT Workshop: Positioning Your Firm. January 21, 2003
DNA: Where it all starts Adenine Thymine Cytosine Guanine The ultimate compression algorithm A 4 letter code, 3 billion letters long… … contains the recipe for building you and me Bio-IT Workshop: Positioning Your Firm. January 21, 2003
Genomics to Proteomics Bioinformatics Sequence Analysis Chemical DB’s, Combinatorial Chemistry, Docking studies Computational Chemistry and Protein Folding Homology Modeling Bio-IT Workshop: Positioning Your Firm. January 21, 2003
From Genotype to Phenotype Bio-IT Workshop: Positioning Your Firm. January 21, 2003
Complex, Deeply Nested Layers of Data Bio-IT Workshop: Positioning Your Firm. January 21, 2003
All this Produces an Information Explosion Bio-IT Workshop: Positioning Your Firm. January 21, 2003
…That must be managed in a both a Public and Private Context Data Domain no direct control of data format Public Partnerships/ Collaborations Present Future Past high level of control of data format Internal Static moderate control of data format Data Type Bio-IT Workshop: Positioning Your Firm. January 21, 2003 Dynamic
Bio-IT Workshop: Positioning Your Firm. January 21, 2003
“In 50 percent of the interactions that I have with vendors, they say, ‘We have a great technology that can help you…. Now tell me about drug discovery ’ ” Rainer Fuchs, vice president of research informatics at Biogen “There does seem to be a disconnect between the value proposition and what is offered, ” Shawn Ramer, vice president of R&D informatics at Bristol-Myers Squibb Bio-IT Workshop: Positioning Your Firm. January 21, 2003
Pharmaceutical R&D $800 M Fully Capitalized Cost to develop $350 M Sales Avg. per year Blockbusters (>$1 B) Carry the rest. . . e. g. Lipitor Bio-IT Workshop: Positioning Your Firm. January 21, 2003
Pharmaceutical R&D Bio-IT Workshop: Positioning Your Firm. January 21, 2003
Conclusion • Current focus is on applied technology… – Must understand the drug discovery process. • Complexity of industry should not be underestimated – Pace of discovery and innovation is staggering – Partnerships and alliances are key • Nobody has the “right” model…. – Everybody knows they need new ways to solve the problem – Fragmentation in solution space makes it difficult to get economies of scale for technology development • But the goal is noble and the prize is large! Bio-IT Workshop: Positioning Your Firm. January 21, 2003
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