UNCCenter for Environmental Health Susceptibility Facilitate Research Susceptibility
UNC-Center for Environmental Health & Susceptibility Facilitate Research Susceptibility (CEHS) Training, Education, Community Engagement Translating interdisciplinary research on environmental health threats to improve public health in North Carolina. Integrated Health Sciences Facility Core Jeannette T. Bensen, MS, Ph. D, Director IHSFC jbensen@med. unc. edu
IHSFC Structure and Function THEME LEADERS ENVIRONMENTAL CANCER PILOT PROJECTS PROGRAM & IAC CARDIO PULMONARY DISEASE DEVELOPMENTAL DISORDERS SUBSEQUENT NIEHS APPLICATION
Integrated Health Sciences Core Facility Specific Aims Jeannette Bensen, IHSFC Director Provide scientific consultation for clinical and translational human subjects studies. RESEARCH Assist with collection, processing, analysis, and storage of biospecimens. Facilitate access to collaborative human studies. CONTINUUM
Heavy Metal Well Water Contamination Geographically-based to Person-based CEHS investigator, Fry & Serre • • Members of COEC meet with state leaders at the NC-Division of Public Health to identify key concerns Historic well water data reported to 65, 000 home owners CEHS scientists define slate belt and arsenic contamination in well water Next…evaluate exposure in individuals with health outcomes
IHSFC – Integration with COEC IHSFC brings together CEHS Environmental Scientists and COEC with Cancer Epidemiology Researchers and Resources CEHS investigator, Fry
IHSFC – Key accomplishments Baby Connectome Project • 500 Typically Developing Children • 0 -5 years of age • Followed 4 years • Brain Imaging • 4 -6 MRIs Environmental Impacts on Early Brain Development *Link environmental toxicant exposures to longitudinal neuroimaging data • Parent Questionnaires • Direct Assessment of Cognitive & Behavioral Development CEHS Pilot Projects Program $$$ *Collecting exposures and specimens CEHS investigators, Piven, Lin, Engel
Integrated Health Sciences Offer Jeannette Bensen, IHSFC Director Ø CEHS-affiliate medical center, UNC Health Care, to facilitate clinical translation Ø Numerous, large, population-based and hospitalbased case-control, case-only, and cohort studies Ø Exposure assessment methodology and expertise (Mass Spec Core Facility) Ø Advanced genomic capabilities (TCGA Site) Ø Specialized animal models (Collaborative Cross) Health Registry Cancer Survivor Cohort
Integrated Health Sciences Ask • Challenged with integrating large amounts of genomic data with exposure data (Big Data) • Data sharing demands • • • Administratively taxing Requires infrastructure (tracking and secure transfer/websites) IRB, consent and data coding implications Date Use Agreements (DUA) Rarely this work is funded • Streamline models for data sharing and collaboration • Could IHSFC be the vehicle for integration and collaboration?
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