UFN Synthetic Polymer Nanostructures Polymer nanoparticles Bennet D

UFN Synthetic Polymer Nanostructures

Polymer nanoparticles Bennet, D. Polymer Nanoparticles for Smart Drug Delivery 2014, ISBN: 978 -953 -51 -1628 -8. 2

Polymer nanoparticles Nicolas, J. et al. Chem. Soc. Rev. 2013, 42, 1147– 1235. 3

Polymer nanoparticles Nicolas, J. et al. Chem. Soc. Rev. 2013, 42, 1147– 1235. 4

Polymer nanoparticles Nicolas, J. et al. Chem. Soc. Rev. 2013, 42, 1147– 1235. 5

Conjugated polymer nanoparticles Feng, L. Chem. Soc. Rev. 2013, 42, 6620– 6633. 6

Polymer nanoparticles Lu, X. -Y. Progress in Molecular Biology and Translational Science 2011, 104, 299– 323. 7

Lipid-based nanoparticles Sapsford, K. -E. et al. Chem. Rev. 2013, 1904– 2074. 8

Lipid-based nanoparticles Sapsford, K. -E. et al. Chem. Rev. 2013, 1904– 2074. 9

Polymer nanoparticles Elsabahy, M. Chem. Soc. Rev. 2012, 41, 2545– 2561. 10

Polymer nanoparticles Elsabahy, M. Chem. Soc. Rev. 2012, 41, 2545– 2561. 11

Polymer nanoparticles Elsabahy, M. Chem. Soc. Rev. 2012, 41, 2545– 2561. 12

Polymer nanoparticles Elsabahy, M. Chem. Soc. Rev. 2012, 41, 2545– 2561. 13

Polymer nanoparticles Aiertza M. K. et al. Cell. Mol. Life Sci. 2012, 69, 337– 346. 14

Polymer nanoparticles Aiertza M. K. et al. Cell. Mol. Life Sci. 2012, 69, 337– 346. 15

Conjugated polymer nanoparticles Feng, L. Chem. Soc. Rev. 2013, 42, 6620– 6633. 16

Conjugated polymer nanoparticles Feng, L. Chem. Soc. Rev. 2013, 42, 6620– 6633. 17

Conjugated polymer NPs (CPN) ROS = reactive oxygen species Feng, L. Chem. Soc. Rev. 2013, 42, 6620– 6633. 18

Polymer nanoparticles PAA – polyacryclic acid PAAPBA – 3 -acrylamidophenylboronic acid Sapsford, K. -E. et al. Chem. Rev. 2013, 1904– 2074. 19

Lipid-based nanoparticles N O Sapsford, K. -E. et al. Chem. Rev. 2013, 1904– 2074. 20

Polymer nanoparticles PLGA – poly(lactic-co-glycolic acid) Nicolas, J. et al. Chem. Soc. Rev. 2013, 42, 1147– 1235. 21

Polymer nanoparticles Nicolas, J. et al. Chem. Soc. Rev. 2013, 42, 1147– 1235. 22

Polymer nanoparticles non-steroidal anti-inflammatory drug, indomethacin, IND Krovi, S. A. et al. Chem. Commun. 2010, 46, 5277– 5279. 23

Polymer nanoparticles Krovi, S. A. et al. Chem. Commun. 2010, 46, 5277– 5279. 24

Polymer nanoparticles O'Reilly, R. K. et al. Journal of Polymer Science Part A: Polymer Chemistry 2006, 44, 5203– 5217. 25

Polymer nanoparticles O'Reilly, R. K. et al. Journal of Polymer Science Part A: Polymer Chemistry 2006, 44, 5203– 5217. 26

Dendrimers Tomalia, D. A. Prog. Polym. Sci. 2005, 30, 294– 324. 27

Dendrimers Esfand, R. et al. Drug Discovery Today 2001, 6, 427– 436. 28

PAMAM Michael reaction http: //en. wikipedia. org/wiki/Poly(amidoamine) 29

PAMAM Tomalia, D. A. Prog. Polym. Sci. 2005, 30, 294– 324. 30

PAMAM Tomalia, D. A. Prog. Polym. Sci. 2005, 30, 294– 324. 31

PAMAM Tomalia, D. A. Prog. Polym. Sci. 2005, 30, 294– 324. 32

PAMAM Sadekar, S. et. al. Advanced Drug Delivery Reviews 2012, 64, 571– 588. 33

Ester dendrimers 34 4 -(dimethylamino)pyridinium p-toluenesulfonate (DPTS) Twibanire J. -d’A. K. et. al. Polymers 2012, 4, 794 -879.

Ester dendrimers 35 TFA – trifluoroacetic acid CDI – carbonyldiimidazole c. RGD – Arg-Gly-Asp The terminal amine groups were converted into carboxylic acids by reaction with glutaric acid. Carbonyldiimidazole was then used to couple a lysine-modified cyclic RGD peptide. Finally, the phenolic group of the tyrosine moieties were deprotected with trifluoroacetic acid in the presence of thioanisole and radiolabeled with 76 Br. Sapsford, K. -E. et al. Chem. Rev. 2013, 1904– 2074.