천식의 중증도 주간증상(매일), 야간증상(1/주) 기준으로 CLASSIFY SEVERITY Clinical Features Before Treatment Symptoms STEP 4 Severe Persistent STEP 3 Moderate Persistent STEP 2 Mild Persistent Nocturnal Symptoms Continuous Limited physical activity Daily Attacks affect activity > 1 time a week but < 1 time a day Frequent > 1 time week > 2 times a month FEV 1 or PEF � 60% predicted Variability > 30% 60 - 80% predicted Variability > 30% � 80% predicted Variability 20 - 30% < 1 time a week STEP 1 Intermittent Asymptomatic and normal PEF between attacks � 2 times a month � 80% predicted Variability < 20% The presence of one feature of severity is sufficient to place patient in that category.
용법의 차이 Controller Reliever Inhaled CS Systemic CS Methylxanthine Inhaled LABA Oral LABA Anti-leukotrienes Inhaled SABA Systemic CS Anticholinergics Methylxanthine Oral SABA 매일 사용 증상이 없어도 사용 규칙적으로 사용 악화시에만 사용 단기간만 사용 GINA guideline, 2002 (2006 update)