Types of Research Fellowship Research Science Course September
“Types of Research” Fellowship Research Science Course September 5, 2019 Marina Reznik, MD, MS Associate Professor of Pediatrics Division of Academic General Pediatrics Department of Pediatrics
Marina Reznik, MD, MS Associate Professor of Pediatrics Division of Academic General Pediatrics Department of Pediatrics Clinical and Community Based Research
Clinical and Community-Based Research • Clinical Research – NIH definition: • Research in which people, or data or samples of tissue from people, are studied to understand health and disease. • Clinical research helps find new and better ways to detect, diagnose, treat, and prevent disease. • Types of clinical research include clinical trials, which test new treatments for a disease, and natural history studies, which collect health information to understand how a disease develops and progresses over time. • Community-Based Research is in the community and benefits community: • Takes place in community settings and involves collaboration with community members in the design and implementation of research projects.
Clinic Home Eliminating Disparities in Asthma Care and Outcomes Disparities in Asthma Care at Different Levels Community Schools Child + Family
Current studies 1. PRAGMATIC (Promoting Asthma Guidelines and Management through Technology-Based Intervention and Care Coordination) (Role: PI) 2. EM-ASTHMA (Electronic Monitoring of Medication Adherence in Moderate to Severe Asthma Patients) (Role: PI) 3. CAM Study (Use of Complementary (Integrative) Therapy by Adolescents with Asthma: A Fifteen Year Follow-up) (Role: PI) 4. Spacer Device Study (Provider Prescription Practices and Pharmacy Availability and Dispensing of Spacer Devices Used with Asthma Inhalers) (Role: PI) 5. Adapting and Evaluating an Enhanced ASTHMAXcel Mobile Application for Youth with Asthma (Role: PI, multi-PI) 6. Adapting, Scaling, and Spreading an Algorithmic Asthma Mobile Intervention to Promote Patient-Reported Outcomes Within Primary Care Settings (Role: Co-I)
Todd Cassese MD, FACP Assistant Dean for Clinical Sciences Education Associate Professor of Medicine Albert Einstein College of Medicine Educational Scholarship
Career Trajectory - Todd Cassese Medical School - University of Chicago. Plan: Physician Scientist (considering MD/Ph. D) Howard Hughes Medical Institute Research Fellowship at NIH (‘definitely’ Ph. D) Epiphany Final Year – University of Chicago Resident IM - UCSF. Resident Teaching Fellowship, Medical Education Area of Distinction, Frequent Med School small group instructor. Chief Resident IM
Educational Scholarship 1. Curriculum Development 2. Curriculum Assessment 3. Perspective Pieces: Application of educational theories to medical education practice 4. Perspective Pieces: Application of theories outside of medical education to medical education practice 5. Professionalism and Professional Identity Formation 6. Burnout and wellness C Laverty (Used without permission)
Kaitlyn Philips, DO, MSc Assistant Medical Director of Pediatric Quality Assistant Professor of Pediatrics Pediatric Hospital Medicine Quality Improvement Research
QI Research
My path • • AIM CLABSI Asst Med Director of Pediatric Quality PI Coach EXPLORE/K 12 PHM Fellowship IHI QI Mentorship MEDRITES Hospital Collaborative CRTP, MS
Preeti Viswanathan, MD Assistant Professor of Pediatrics Division of Pediatric Gastroenterology Basic/ Translational Research
Basic/Translational Research Definition of basic science/translational research. Location of research: Lab/Einstein Campus Scope of work to be done: • Identify a project relevant to your clinical interest/work • Learn Lab techniques and possibly animal work • Data compilation/analysis • Grant/Manuscript writing Lab etiquette: Timeliness, planning, care of material/reagants. Become independent early! Career trajectory: manuscript grants More manuscripts More grants promotion nobel prize Ongoing projects: Acute liver failure, mechanisms in liver injury and regeneration, role of DNA damage in pediatric fatty liver disease T 1 T 2 T 3 T 4
Ongoing projects RESEARCH FOCUS: Mechanisms in liver injury and regeneration- Role of DNA damage and inflammation 1. Acute liver failure Ø Cell cycle restrictions following APAP toxicity Ø Role of liver stem cells in acute liver failure Ø Role of micro. RNA in determining susceptibility to ALF and reversal by gene therapy Ø GCSFR as a therapeutic target in ALF 2. Pediatric fatty liver disease Ø Role of DNA damage response in disease progression Experimental systems used: human liver samples, cell culture systems, mouse models Experimental methods: immune histochemical and fluorescence staining, image analysis, DNA, RNA, protein expression, pathway analysis,
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