Tumor necrosis factor receptor signaling is a driver

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Tumor necrosis factor receptor signaling is a driver of chronic lymphocytic leukemia that can

Tumor necrosis factor receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin by Claudia Dürr, Bola S. Hanna, Angela Schulz, Fabienne Lucas, Manuela Zucknick, Axel Benner, Andrew Clear, Sibylle Ohl, Selcen Öztürk, Thorsten Zenz, Stephan Stilgenbauer, Min Li-Weber, Peter H. Krammer, John G. Gribben, Peter Lichter, and Martina Seiffert haematol Volume 103(4): 688 -697 March 23, 2018 © 2018 by Ferrata Storti Foundation

Elevated s. TNFR-1 serum levels have prognostic relevance in CLL. (A) Serum levels of

Elevated s. TNFR-1 serum levels have prognostic relevance in CLL. (A) Serum levels of s. TNFR-1 in 247 CLL patients and 50 age and sex-matched healthy donors were assessed by flow cytometry using bead arrays. Claudia Dürr et al. Haematologica 2018; 103: 688 -697 © 2018 by Ferrata Storti Foundation

TNFR-1 expression in CLL cells is regulated by the microenvironment. Claudia Dürr et al.

TNFR-1 expression in CLL cells is regulated by the microenvironment. Claudia Dürr et al. Haematologica 2018; 103: 688 -697 © 2018 by Ferrata Storti Foundation

TNFR-1 is expressed by proliferating B cells in bone marrow and lymph nodes. Claudia

TNFR-1 is expressed by proliferating B cells in bone marrow and lymph nodes. Claudia Dürr et al. Haematologica 2018; 103: 688 -697 © 2018 by Ferrata Storti Foundation

TNF-α-induced NFκB activity in CLL cells is inhibited by wogonin. Claudia Dürr et al.

TNF-α-induced NFκB activity in CLL cells is inhibited by wogonin. Claudia Dürr et al. Haematologica 2018; 103: 688 -697 © 2018 by Ferrata Storti Foundation

CLL-associated TNFR-1 expression in Eμ-TCL 1 mice. Claudia Dürr et al. Haematologica 2018; 103:

CLL-associated TNFR-1 expression in Eμ-TCL 1 mice. Claudia Dürr et al. Haematologica 2018; 103: 688 -697 © 2018 by Ferrata Storti Foundation

Wogonin reduces leukemia development in the TCL 1 adoptive transfer model. Claudia Dürr et

Wogonin reduces leukemia development in the TCL 1 adoptive transfer model. Claudia Dürr et al. Haematologica 2018; 103: 688 -697 © 2018 by Ferrata Storti Foundation

Wogonin impacts on TNFR-1 expression in vivo. Claudia Dürr et al. Haematologica 2018; 103:

Wogonin impacts on TNFR-1 expression in vivo. Claudia Dürr et al. Haematologica 2018; 103: 688 -697 © 2018 by Ferrata Storti Foundation

Tumor Necrosis Factor Receptor Expression and Signaling inTumor Necrosis Factor Receptor Expression and Signaling in
Interleukin1 and Tumor Necrosis Factor Receptor Signaling IsInterleukin1 and Tumor Necrosis Factor Receptor Signaling Is
Interleukin1 and Tumor Necrosis Factor Receptor Signaling IsInterleukin1 and Tumor Necrosis Factor Receptor Signaling Is
CELL DEATH or NECROSIS What is Necrosis NecrosisCELL DEATH or NECROSIS What is Necrosis Necrosis
Interferon ReceptorMediated but Not Tumor Necrosis Factor ReceptorInterferon ReceptorMediated but Not Tumor Necrosis Factor Receptor
Reduced Display of Tumor Necrosis Factor Receptor IReduced Display of Tumor Necrosis Factor Receptor I
Summary Proteolytic signaling by TNFalpha 1 Tumor necrosisSummary Proteolytic signaling by TNFalpha 1 Tumor necrosis