Trisomy 12 chronic lymphocytic leukemia expresses a unique Slides: 7 Download presentation Trisomy 12 chronic lymphocytic leukemia expresses a unique set of activated and targetable pathways by Lynne V. Abruzzo, Carmen D. Herling, George A. Calin, Christopher Oakes, Lynn L. Barron, Haley E. Banks, Vikram Katju, Michael J. Keating, and Kevin R. Coombes haematol Volume 103(12): 2069 -2078 November 30, 2018 © 2018 by Ferrata Storti Foundation Patients’ characteristics of the discovery set. Lynne V. Abruzzo et al. Haematologica 2018; 103: 2069 -2078 © 2018 by Ferrata Storti Foundation Patients’ characteristics of the validation set. Lynne V. Abruzzo et al. Haematologica 2018; 103: 2069 -2078 © 2018 by Ferrata Storti Foundation Kaplan Meier plots stratified by cytogenetic subtype. Lynne V. Abruzzo et al. Haematologica 2018; 103: 2069 -2078 © 2018 by Ferrata Storti Foundation Results of two-way clustering according to cytogenetic subtype using the genes found to be differentially expressed. Lynne V. Abruzzo et al. Haematologica 2018; 103: 2069 -2078 © 2018 by Ferrata Storti Foundation Ingenuity Pathway Analysis of differentially-regulated canonical pathways. Lynne V. Abruzzo et al. Haematologica 2018; 103: 2069 -2078 © 2018 by Ferrata Storti Foundation Construction of a specific trisomy 12 (+12) CLL gene expression network. Lynne V. Abruzzo et al. Haematologica 2018; 103: 2069 -2078 © 2018 by Ferrata Storti Foundation