TRANSLATION PROTEIN RNA PROTEIN SYNTHESIS MAKING A PROTEIN

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TRANSLATION (PROTEIN RNA PROTEIN SYNTHESIS)

TRANSLATION (PROTEIN RNA PROTEIN SYNTHESIS)

MAKING A PROTEIN • Many RNAs needed • m. RNA, t. RNA, r. RNA

MAKING A PROTEIN • Many RNAs needed • m. RNA, t. RNA, r. RNA

MESSENGER RNA (MRNA) • Carries coded instructions for protein synthesis (translation) • From the

MESSENGER RNA (MRNA) • Carries coded instructions for protein synthesis (translation) • From the DNA in the nucleus to the ribosome

THE GENETIC CODE • Codons • instructions for making a protein, a series of

THE GENETIC CODE • Codons • instructions for making a protein, a series of three nucleotides on the m. RNA • Each codon signifies start, stop, or an amino acid

THE GENETIC CODE

THE GENETIC CODE

TRANSFER RNA (TRNA) • Brings amino acids to the ribosome so it can build

TRANSFER RNA (TRNA) • Brings amino acids to the ribosome so it can build proteins • It has Anticodons • 3 nucleotide sequence complementary to the m. RNA codon

RIBOSOMAL RNA (RRNA) • Makes up ribosomes

RIBOSOMAL RNA (RRNA) • Makes up ribosomes

MAKING A PROTEIN • m. RNA from nucleus Through cytoplasm to the ribosome m.

MAKING A PROTEIN • m. RNA from nucleus Through cytoplasm to the ribosome m. RNA start codon AUG signals beginning of protein

MAKING A PROTEIN • t. RNA with the complementary anticodon carries amino acid (a.

MAKING A PROTEIN • t. RNA with the complementary anticodon carries amino acid (a. a. ) to bind to the codon

MAKING A PROTEIN • • • Enzymes help form peptide bonds between amino acids

MAKING A PROTEIN • • • Enzymes help form peptide bonds between amino acids This continues until a stop codon is reached Protein is released into the cell Watch This one too!

DO WE NEED NEW MRNA EVERY TIME? • NO • The same m. RNA

DO WE NEED NEW MRNA EVERY TIME? • NO • The same m. RNA may be used to make many copies of the same protein.

MUTATIONS • Point mutation • Change in one or a few nucleotides

MUTATIONS • Point mutation • Change in one or a few nucleotides

MUTATIONS • Substitution • can have no effect • Protein could not be made

MUTATIONS • Substitution • can have no effect • Protein could not be made • Protein made w/ wrong amino acid (nonfunctional protein)

MUTATIONS • Insertions/deletions • 1 or more nucleotides added or deleted • Can result

MUTATIONS • Insertions/deletions • 1 or more nucleotides added or deleted • Can result in frame shift mutations