Transient inhibition of NFB signaling enhances ex vivo

Transient inhibition of NF-κB signaling enhances ex vivo propagation of human hematopoietic stem cells by Mehrnaz Safaee Talkhoncheh, Agatheeswaran Subramaniam, Mattias Magnusson, Praveen Kumar, Jonas Larsson, and Aurélie Baudet haematol Volume 103(9): 1444 -1450 August 31, 2018 © 2018 by Ferrata Storti Foundation

The sh 758 -dependent ex vivo expansion effect is associated with a downmodulation of the NFκB pathway. Mehrnaz Safaee Talkhoncheh et al. Haematologica 2018; 103: 1444 -1450 © 2018 by Ferrata Storti Foundation

Targeting of the NF-κB regulator IKKβ increases the number of human hematopoietic stem and progenitor cells (HSPCs) in vitro without affecting cell proliferation and survival. Mehrnaz Safaee Talkhoncheh et al. Haematologica 2018; 103: 1444 -1450 © 2018 by Ferrata Storti Foundation

Targeting of the NF-κB regulator IKKβ improves the in vitro and in vivo function of cultured cord blood (CB)-derived hematopoietic stem and progenitor cells (HSPCs). Mehrnaz Safaee Talkhoncheh et al. Haematologica 2018; 103: 1444 -1450 © 2018 by Ferrata Storti Foundation

The benefit of NF-κB pathway inhibition is limited to a short time window, and results in downregulation of inflammatory signaling. Mehrnaz Safaee Talkhoncheh et al. Haematologica 2018; 103: 1444 -1450 © 2018 by Ferrata Storti Foundation