Transferrin receptor 2 and HFE regulate furin expression Slides: 8 Download presentation Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signalregulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation by Maura Poli, Sara Luscieti, Valentina Gandini, Federica Maccarinelli, Dario Finazzi, Laura Silvestri, Antonella Roetto, and Paolo Arosio haematol Volume 95(11): 1832 -1840 October 31, 2010 © 2010 by Ferrata Storti Foundation Effects of Tf. R 2 and HFE silencing. Maura Poli et al. Haematologica 2010; 95: 1832 -1840 © 2010 by Ferrata Storti Foundation Treatment of Hep. G 2 cells with BMP 2. Maura Poli et al. Haematologica 2010; 95: 1832 -1840 © 2010 by Ferrata Storti Foundation Effect of holotransferrin in cells expressing HFE and Tf. R 2. Maura Poli et al. Haematologica 2010; 95: 1832 -1840 © 2010 by Ferrata Storti Foundation Furin expression in Tf. R 2−/− mice. Maura Poli et al. Haematologica 2010; 95: 1832 -1840 © 2010 by Ferrata Storti Foundation Inhibition of furin activity. Maura Poli et al. Haematologica 2010; 95: 1832 -1840 © 2010 by Ferrata Storti Foundation Treatment with dorsomorphin and U 0126. Maura Poli et al. Haematologica 2010; 95: 1832 -1840 © 2010 by Ferrata Storti Foundation Proposed scheme of the signaling pathway by Tf. R 2 and HFE. Holotransferrin by binding to Tf. R 2 in a complex with HFE, induces Erk 1/2 phosphorylation. Maura Poli et al. Haematologica 2010; 95: 1832 -1840 © 2010 by Ferrata Storti Foundation Hepcidin ferroportinNovec hfeQuadratic formula examplesRegulate public conduct and set out duties owed to society.Effect of insulin on carbohydrate metabolismInsulin and insulin receptorWhat does mla regulateTriunghiuri isoscelePoligon convex cu 4 laturi