Transferrin receptor 2 and HFE regulate furin expression

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Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signalregulated kinase

Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signalregulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation by Maura Poli, Sara Luscieti, Valentina Gandini, Federica Maccarinelli, Dario Finazzi, Laura Silvestri, Antonella Roetto, and Paolo Arosio haematol Volume 95(11): 1832 -1840 October 31, 2010 © 2010 by Ferrata Storti Foundation

Effects of Tf. R 2 and HFE silencing. Maura Poli et al. Haematologica 2010;

Effects of Tf. R 2 and HFE silencing. Maura Poli et al. Haematologica 2010; 95: 1832 -1840 © 2010 by Ferrata Storti Foundation

Treatment of Hep. G 2 cells with BMP 2. Maura Poli et al. Haematologica

Treatment of Hep. G 2 cells with BMP 2. Maura Poli et al. Haematologica 2010; 95: 1832 -1840 © 2010 by Ferrata Storti Foundation

Effect of holotransferrin in cells expressing HFE and Tf. R 2. Maura Poli et

Effect of holotransferrin in cells expressing HFE and Tf. R 2. Maura Poli et al. Haematologica 2010; 95: 1832 -1840 © 2010 by Ferrata Storti Foundation

Furin expression in Tf. R 2−/− mice. Maura Poli et al. Haematologica 2010; 95:

Furin expression in Tf. R 2−/− mice. Maura Poli et al. Haematologica 2010; 95: 1832 -1840 © 2010 by Ferrata Storti Foundation

Inhibition of furin activity. Maura Poli et al. Haematologica 2010; 95: 1832 -1840 ©

Inhibition of furin activity. Maura Poli et al. Haematologica 2010; 95: 1832 -1840 © 2010 by Ferrata Storti Foundation

Treatment with dorsomorphin and U 0126. Maura Poli et al. Haematologica 2010; 95: 1832

Treatment with dorsomorphin and U 0126. Maura Poli et al. Haematologica 2010; 95: 1832 -1840 © 2010 by Ferrata Storti Foundation

Proposed scheme of the signaling pathway by Tf. R 2 and HFE. Holotransferrin by

Proposed scheme of the signaling pathway by Tf. R 2 and HFE. Holotransferrin by binding to Tf. R 2 in a complex with HFE, induces Erk 1/2 phosphorylation. Maura Poli et al. Haematologica 2010; 95: 1832 -1840 © 2010 by Ferrata Storti Foundation