transcriptional control posttranscriptional control RNA RNA processing control

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• 主要调控水平： *－转录水平调控（transcriptional control） *－转录后水平调控（post-transcriptional control） RNA加 水平调控（RNA processing control） 翻译水平调控（translational control） －蛋白质的翻译后修饰（post-translational

• 主要调控水平： *－转录水平调控（transcriptional control） *－转录后水平调控（post-transcriptional control） RNA加 水平调控（RNA processing control） 翻译水平调控（translational control） －蛋白质的翻译后修饰（post-translational modification）

（一）、转录的激活（transcriptional activation） 1，转录的起始 涉及一系列的DNA/protein, protein/protein 相互作用；转录 起始复合体（pre-initiation complex）的形成，etc. RNA polymerase II (side cutway) Aaron

（一）、转录的激活（transcriptional activation） 1，转录的起始 涉及一系列的DNA/protein, protein/protein 相互作用；转录 起始复合体（pre-initiation complex）的形成，etc. RNA polymerase II (side cutway) Aaron Klug, 2001, Science, 292: 1844 -46

真核基因转录的调控（gene control regions）

真核基因转录的调控（gene control regions）

（一）、m. RNA 的细胞定位 • m. RNA 在细胞质中的不均一性（见前）：如何定位？ 决定： 3’-UTR 中的信息，可能涉及蛋白质的参与； 转运：微管（microtubule）的作用； 锚定：微丝（microfilaments）的作用。 m. RNA

（一）、m. RNA 的细胞定位 • m. RNA 在细胞质中的不均一性（见前）：如何定位？ 决定： 3’-UTR 中的信息，可能涉及蛋白质的参与； 转运：微管（microtubule）的作用； 锚定：微丝（microfilaments）的作用。 m. RNA 定位的几种方式: Left: travel by associateion with cytoskeleton motor; Center: random diffusion; Right: degradation of unanchored m. RNAs; Black open circus: anchor complex

Control of gene expression Transcriptional Posttranscriptional Epigenetics andControl of gene expression Transcriptional Posttranscriptional Epigenetics and
Control of gene expression Transcriptional Posttranscriptional Epigenetics andControl of gene expression Transcriptional Posttranscriptional Epigenetics and
Posttranscriptional Processes Processing of eukaryotic prem RNA cappingPosttranscriptional Processes Processing of eukaryotic prem RNA capping
t RNA t RNA Transfer RNA t RNAt RNA t RNA Transfer RNA t RNA
RNA RNA RNA ribonucleic acid RNA is aRNA RNA RNA ribonucleic acid RNA is a
RNA m RNA informacijska RNA r RNA ribosomskaRNA m RNA informacijska RNA r RNA ribosomska
Transcriptional Regulation of Eukaryotic Genes 1 Transcriptional initiationTranscriptional Regulation of Eukaryotic Genes 1 Transcriptional initiation
Chap 8 Posttranscriptional Gene Control Topics Processing ofChap 8 Posttranscriptional Gene Control Topics Processing of
Transcription RNA Processing and Transcriptional Regulation A BTranscription RNA Processing and Transcriptional Regulation A B
PostTranscriptional Gene Silencing PTGS Also called RNA interferencePostTranscriptional Gene Silencing PTGS Also called RNA interference
Posttranscriptional Modification of RNA A primary transcript isPosttranscriptional Modification of RNA A primary transcript is
POLYADENYLATION Posttranscriptional Processes II Pre m RNA PolyadenylationPOLYADENYLATION Posttranscriptional Processes II Pre m RNA Polyadenylation
Posttranscriptional Modification of RNA Effect on Biology andPosttranscriptional Modification of RNA Effect on Biology and
Posttranscriptional Modification of RNA A primary transcript isPosttranscriptional Modification of RNA A primary transcript is
Serum Withdrawalinduced Posttranscriptional Stabilization of Cyclooxygenase2 m RNASerum Withdrawalinduced Posttranscriptional Stabilization of Cyclooxygenase2 m RNA
RNA PROCESSING AND RNPs RNA Processing Very fewRNA PROCESSING AND RNPs RNA Processing Very few
RNA PROCESSING Part1 m RNA processing Transcription mRNA PROCESSING Part1 m RNA processing Transcription m
Posttranscriptional events III others 1 Processing of rPosttranscriptional events III others 1 Processing of r
DATA PROCESSING EDITING CODING PROCESSING Data Processing ProcessingDATA PROCESSING EDITING CODING PROCESSING Data Processing Processing
DNA DNA RNA DNA RNA DNA RNA DNADNA DNA RNA DNA RNA DNA RNA DNA
RNA and Protein Synthesis RNA Compare RNA toRNA and Protein Synthesis RNA Compare RNA to
RNA polimerasi eucariotiche RNA polymerases RNA polymerase IRNA polimerasi eucariotiche RNA polymerases RNA polymerase I
m RNA t RNA y r RNA CAm RNA t RNA y r RNA CA
circular RNA 10 circ RNA RNAmessenger RNAm RNAcircular RNA 10 circ RNA RNAmessenger RNAm RNA