Effects of toxicants on the cardiovascular system There are several different injury mechanism associated with cardiac toxicants. � Generation of free redicals � Lipid peroxidation � Impaired membrane integrity � Mitochondrial dysfunction � Sarcoplasmic reticulum dysfunction � Altered calcium homeostasis
Cardiotoxicants and the associated injuries
Blood toxicology � Direct and indirect damage to the hematopoietic system may produce hypoxia, hemorrhage, infection and death. � Primary hematotoxicity � Secondary hematotoxicity