Towards Stem Materials A new generation of bioinspired

Towards Stem Materials: A new generation of bio-inspired materials: technological and scientific challenges “…Once you have tasted flight, you will forever walk the earth with your eyes turned skyward” Pier Francesco Moretti ULB, Brussels - 25 June 2019 Pier Francesco Moretti – CNR “…chi ha provato il volo, camminerà guardando il cielo”

Rationale What (do we expect) What (do we know) What (do we need to solve) Pier Francesco Moretti – CNR Why and how: the back-casting foresight

The different approaches of foresight Pier Francesco Moretti – CNR

Building the path towards the future Where are we going? vs Where do we want to go? BUILDING = backcasting Pier Francesco Moretti – CNR ADAPTING = forecasting

What we expect from Materials FOOD ENERGY WATER HEALTH Pier Francesco Moretti – CNR MATERIALS as enablers

Building the path towards the future: if in 1998…. Pier Francesco Moretti – CNR Facebook 2004 Smart phone 2008 DNA sequencing 2006 1 st CRISPR 2016 ? h g 1 quantum message 2015 u o r h t ak n, i e r e t First human transplantic of” stem cell 2017 b s n i E f , i r t u n e t st e s i a c 1 animal cloning 1996 P s , “ i t n o a c ar Wh e-commerce M , a t Amazon 1997 l s o e V i , r i … e n a v o c s Galvdrone arie-Curie… i Parrot 2010 d f ! o s y M n t , i i l o i i t m b s a 3 d-printing 1986 e t Fer c u i q d t e r h p g i n r u e Highway-capable electric vehicle 2014 h t f rom o F n o i t a First Nanomotor 2004 c i f i t n ide underwater com toinduced Laser 2016 AKIDA neuromorphic chip 2018 Non-invasive brain-computer interface 1999 AI 4 reason 2016

What do we expect for next generation of materials The dream Multi-Functionality Organisms! with limited number of primary components and chemical bonds, organized in complex systems capable to adapt to diversified environments. The visionary proposal Stem Materials: use of primitive units which, even if not able to differentiate spontaneously in several other types, undergo a process of transformation aimed to make them capable of adapt to specific requirements. Main questions: 1) Are there primitive units for materials? 2) Can we address functions to the units? 3) Can be these units assembled/transformed to adapt? Pier Francesco Moretti – CNR + sustainability + endurance + [performance] A clue

Is this science fiction? First scoping workshop, March 2017: what do we know or need to know better Chemical Synthetic Biology: from information to the adapting to the exposome 10 top-scientists: 3 ERC grantees et al. (Calarco, Vulpiani, Marzari, Luisi…) Pier Francesco Moretti – CNR Material Science: the genetic code for materials

What do we need to address The technological and scientific challenges: SYSTEMIC APPROACH CONTEXT DEPENDENCY MULTI-SCALE SUSTAINABILITY SYNTHETIC BIOLOGY QUASI-BIO MACHINE LEARNING COGNITION STRUCTURE ASSEMBLING INTEGRATION Pier Francesco Moretti – CNR NON-EQUILIBRIUM

Different paths foresight. cnr. it/working-groups/wg-materials www. pierfrancescomoretti. eu/pag%20 foresight. html Pier Francesco Moretti – CNR While experiments and analogies seem to drive the advances in these researches, we have two options: 1) to achieve a general and breakthrough mathematical framework for primitive units, as a sort of ribosome of Materials, and their combinations and/or 2) an accurate and flexible empirical framework to satisfy any request for functionality and performance of materials.

Multi-cross-disciplinarity Second face-to-face workshop, December 2018: 20 top-scentists from KR, CH, PT, DE, NL, IT…how to proceed. Living Materials systems Non-equilibrium of nanostructures The role of chaos and rhythms in order and functioning A whole-cell computational model: phenotype vs genotype …and: topology, neuromorphic circuits, 4 D materials, epigenetics, quantum mechanics. Pier Francesco Moretti – CNR The Materials' Genetic code

What do we need to focus on multi-states systems NETWORKS & SCALES Space-time organization & dynamics Transport/ meaning of info/energy Pier Francesco Moretti – CNR INTERFACES & Non-equilibr.

How to “focus” Medicine Material Science Chemistry Biology Sociology Maths Model 1 Model 2 … Model n Experiment 1 Experiment 2 … Experiment m Pier Francesco Moretti – CNR Physics

The ABra. CAdabra C B Can we design, test, learn? Pier Francesco Moretti – CNR A

KEY MESSAGES From “From ideas to market” to From a market which does not exist to an integration of ideas” Pier Francesco Moretti – CNR From “Internet OF Things” to “Internet IN Things”

Pier Francesco Moretti – CNR It is not fiction: organisms exist!