Tissue Engineering and Regenerative Medicine A Biomedical and

Tissue Engineering and Regenerative Medicine A Biomedical and Classroom Revolution

Tissue Engineering and Regenerative Medicine 1. 2. 3. It’s HOT! It’s Relevant! Everybody is a potential candidate for its application. It helps answer the dreaded question: “Why do we have to learn all this stuff? ” It’s multidisciplinary, a new trend in science and education It’s a ‘Burgh Thing!

Five hottest jobs for the next millennium will be bioengineering/biomedical related. Tissue Engineering Hottest job for 21 st Century

What is Tissue Engineering? n Broadly Defined: Tissue Engineering is the development and manipulation of artificial implants, laboratory-grown tissues, genetically engineered cells and/or molecules to replace or support the function of defective or injured parts of the body.

No One Discipline Can Tackle the Problem Alone Lee Weiss, Carnegie Mellon

Answering TE questions: Old School vs. New School Materials Science Chemical Engineering Genomics Molecular Biology Clinicians Robotics Cell Biology Biochemistry Computational Biology

Guided Tissue Repair Growth factors If needed, harvest cells from patient. Cells Biomimetic extracellular matrix Lee Weiss, Carnegie Mellon Culture Implant

Variations On a Theme Lee Weiss, Carnegie Mellon

Principles of TE & What are we made of? Cells ECM Defect Hormones Phil Campbell, Carnegie Mellon Regeneration Blood Supply

Tissue Structure and Function may be Compromised By: 1. 2. 3. 4. 5. 6. Inherent design flaws Hereditary/congenital defects or conditions Disease Trauma Environmental influences/insults Aging

Potential Solutions: 1. 2. 3. 4. 5. 6. 7. Surgical or physical manipulation Drug therapy Diet/lifestyle changes Transplants Artificial tissues/organs Gene therapy Tissue Engineering/Regenerative Medicine

The ‘burgh, THEN….

Same area, NOW…

Stephen Badylak, Ph. D, MD, DVM SIS ECM n SIS, ECM for repair of soft tissues. Once in place, the matrix, a 3 dimensional scaffold void of cells but with structural and functional proteins still intact, serves to recruit the appropriate cells for tissue remodeling without producing scarring.

First marine mammal application of ECM tissue repair! Meet Liko, 3 -year old dolphin at Dolphin Quest on Hawaii’s Big Island, Liko sustained a tear at base of his dorsal (top) fin -- likely in a game of “chase” with his dolphin cohorts. Thanks to Dr. Badylak’s SIS ECM, Liko has healed and is again performing.

An Ultimate Vision for Regenerative Medicine: Complete Tissue Regeneration Spinal Cord Retina and Lens Tail Upper and Lower Jaw Heart Limb The Newt Phil Campbell, Carnegie Mellon From Dr. Susan Bryant, Univ. from of Calif. , Irvine Adapted Brockes