Tirofiban MetaAnalysis 1 Tirofiban MetaAnalysis Efficacy at 30

Tirofiban Meta-Analysis 1

Tirofiban Meta-Analysis: Efficacy at 30 Days % of Patients Administration Pre-Angiography (Upstream) and PCI Likely (Downstream) P<. 00001 P=. 001 *12 g/kg bolus over 30 min (upstream) and 10 g/kg bolus & 25 g/kg bolus (downstream) Valgimigli M, et al. EHJ. Published online September 14, 2009. 2

Tirofiban Meta-Analysis: Death or MI at 30 Days % of Patients Administration Pre-Angiography (Upstream) and PCI Likely (Downstream) P=. 002 P=. 006 P=. 07 m m *Bolus over 30 Minutes (Upstream) Valgimigli M, et al. EHJ. Published online September 14, 2009. m During PCI (Downstream) 3

Tirofiban Meta-Analysis: Mortality at 30 Days % of Patients Administration Pre-Angiography (Upstream) and PCI Likely (Downstream) P=. 01 P=. 07 P=. 25 m m *Bolus over 30 Minutes (Upstream) Valgimigli M, et al. EHJ. Published online September 14, 2009. m During PCI (Downstream) 4

Tirofiban Meta-Analysis: Safety at 30 Days % of Patients Administration Pre-Angiography (Upstream) and PCI Likely (Downstream) P=. 002 P=. 24 *12 g/kg bolus over 30 min (upstream) and 10 g/kg bolus & 25 g/kg bolus (downstream) Valgimigli M, et al. EHJ. Published online September 14, 2009. 5

Tirofiban Meta-Analysis: Efficacy at 30 Days % of Patients Administration when PCI Likely or Planned (Downstream) P=. 11 P=. 70 *10 g/kg bolus & 25 g/kg bolus (downstream) Valgimigli M, et al. EHJ. Published online September 14, 2009. 6

Tirofiban Meta-Analysis: Death or MI at 30 Days Administration when PCI Likely or Planned (Downstream) % of Patients P=. 03 P=. 54 m m *10 g/kg bolus & 25 g/kg bolus (downstream) Valgimigli M, et al. EHJ. Published online September 14, 2009. 7

Tirofiban Meta-Analysis: Mortality at 30 Days % of Patients Administration when PCI Likely or Planned (Downstream) P=. 38 P=. 65 m m *10 g/kg bolus & 25 g/kg bolus (downstream) Valgimigli M, et al. EHJ. Published online September 14, 2009. 8

Tirofiban Meta-Analysis: Safety at 30 Days % of Patients Administration when PCI Likely or Planned (Downstream) P<. 001 P=. 04 *10 g/kg bolus & 25 g/kg bolus (downstream) Valgimigli M, et al. EHJ. Published online September 14, 2009. 9

Tirofiban Meta-Analysis: Death or MI at Long-Term Follow Up % of Patients Administration when PCI Likely or Planned (Downstream) P=. 34 P=. 10 m P=. 35 m *10 g/kg bolus & 25 g/kg bolus (downstream) Valgimigli M, et al. EHJ. Published online September 14, 2009. 10

Tirofiban Meta-Analysis: Key Points • Tirofiban when compared with placebo or bivalirudin at 30 days – Significantly reduced mortality and the composite of death or MI • 12 g/kg Bolus (label) administered over 30 minutes (Upstream) – Significantly reduced mortality and the composite of death or MI • 25 g/kg Bolus (Downstream) – Significantly reduced the composite of death or MI – Significantly increased TIMI minor bleeding and thrombocytopenia – Demonstrated no significant difference in TIMI major bleeding 11

Tirofiban Meta-Analysis: Key Points • Tirofiban when compared with abciximab (Downstream only) – Demonstrated no significant difference in mortality and the composite of death or MI at 30 days or long-term follow up • 10 g/kg Bolus – TARGET Trial (Downstream) – Demonstrated a significant increase in the composite of death or MI at 30 days, which was lost at long-term follow up – Demonstrated no significant difference in mortality at 30 days or at long-term follow up • 25 g/kg Bolus (Downstream) – Demonstrated no significant difference in mortality or the composite of death or MI at 30 days or at long-term follow up – Significantly reduced TIMI minor bleeding and thrombocytopenia – Demonstrated no significant difference in TIMI major bleeding 12