Tilskuddsparadiset USA Erfaringer med bruk av tilskudd i

Tilskuddsparadiset USA: Erfaringer med bruk av tilskudd i klinisk praksis sammenlignet med Norge Vitamindagene, Sandvika 23. mars, 2019 Oddveig Myhre, Naturterapeut (Norge) Naturopathic Medical Doctor (USA), MS Neuroimmunology, MA Food Studies (USA)

Min utdannelse og erfaring • 1997: San Diego State University: BS Microbiology • 2002: Arizona State University: Masters of Science • • Microbiology/Neuroimmunology 2005: Southwest College of Naturopathic Medicine and Health Sciences: Naturopathic Medical Doctor (NMD / ND) Lege i USA med egen praksis (Phoenix Naturopathic Center i Scottsdale, AZ) o Lisens nr: 06935 o National Provider ID: 1386761443 Skrevet 3 skolebøker for naturmedisin (med 2 kollegaer) 2014: Chatham University, Pittsburgh: MA in Food Studies o Flyttet tilbake til Norge • Mars 2016 – Godkjent som Naturterapeut • Jobber hos Optimalhelse Senter Skien – OSS – som Naturterapeut. o www. velkommentiloss. no

Part I: Del 1: 5 deler – 4. 5 timer Del 2: praktisk eksam Part II (embedseksamen): Går over 5 dager Del 1: Biomedical Science: 2 deler, hver på 2. 5 timer Del 2: Core Clinical Science: 3 deler over 3 d, 3. 5 t hver Del 3: Clinical Electives: 3 deler, 1. 5 time hver

www. scnm. edu

Forskningskilder • Kilder: o US National Library of Medicine/ National Institutes of Health – PUBMED o PMID: 28682528 • Google Scholar • Referanser/Kilder oppgitt

Intravenøs ernæringsbehandling • Ernæring administrert rett inn i blodårer enten som et push (direkte fra sprøyte) eller fra bag (sterilt vann/Ringers/0. 9% Na. Cl) • Premisser: o Når oral behandling ikke fungerer • Mye brukt med fordøyelsesproblemer o Når behandlingsdosen er høyere enn hva fordøyelsen tåler o Pasienten skal sjekkes for: • Serum chemistry profile with electrolytes (metabolisk panel/BMP) • Complete blood count (CBC) with differential • Complete urinalysis o Weight

Mest vanlige og populære intravenøse ernæringsbehandlinger • Glutathione IV o Grå stær, grønn stær, alkoholisme, astma, kreft, hjerte og karsykdommer, høyt kolesterol, AIDs, ME, Alzheimers, osteoartrose, Parkinson’s, diabetes, COPD/KOLS, allergier, IBS, Crohn’s og redusert lever funksjon. • Alpha Lipoic Acid IV o diabetes, diabetes neuropathy, lever sykdommer, slag og andre nevrologiske sykdommer • Chelation IV o Calcium EDTA/disodium EDTA – fjerner tungmetaller i kroppen (bly, kvikksølv), øker blodsirkulasjonen, høyt blodtrykk, CVD, demens, autisme, diabetes med mer

Mest vanlige og populære IV behandlinger • Rapid Mineral Replacement (RMR) IV o Øker mineraler og elektrolytter i kroppen – øker energi, ME, stress relaterte problemer, utmattelse, generell følelse av tretthet • Magnesium IV o Atrial eller ventrikulær arrhythmia (som resultat av hjerteinfarkt), astma, KOLS, nervesmerter, hypertensjon, PVCs, tretthet, fibromyalgi, ME og hjerte og karsykdommer • High-dose Vitamin C IV o For immunforsvaret, mot kreft, motvirke bivirkningene av cellegift og stråle behandling. o Brukes av Cancer Treatment Center of America hvor MD, DO og NMD jobber sammen

Høye doser av Vitamin C • For immunforsvaret • Ekstra tester: o Red blood cell G 6 PD (must be normal) • Glucose 6 phosphate dehydrogenase deficiency o Hemachromatose [1] Hoffer LJ, Levine M, Assouline S, Melnychuk D, Padayatty SJ, Rosadiuk K, Rousseau C, Robitaille L, Miller WH, Jr. : Phase I clinical trial of i. v. ascorbic acid in advanced malignancy. Ann Oncol 2008, 19: 1969 -1974. [2] Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, Levine M: Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci U S A 2005, 20; 102: 13604 -13609. [3] Espey MG, Chen P, Chalmers B, Drisko J, Sun AY, Levine M, Chen Q: Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer. Free Radic Biol Med 2011, 50: 1610 -1619. [4] Monti DA, Mitchell E, Bazzan AJ, Littman S, Zabrecky G, Yeo CJ, Pillai MV, Newberg AB, Deshmukh S, Levine M: Phase I evaluation of intravenous ascorbic Acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. PLo. S One 2012, 7: e 29794.

• • • • • • • • • • Forskning REFERENCES Agus, D. , Vera, J. & Golde, D. , 1999. Stromal cell oxidation: a mechanism by which tumors obtain vitamin C. Cancer Res. , Volume 59, pp. 4555 -8. Ashino, H. et al. , 2003. Novel function of ascorbic acid as an angiostatic factor. Angiogenesis, Volume 6, pp. 259 -69. Belin, S. et al. , 2009. Antiproliferative effect of ascorbic acid is associated with inhibition of genes necessary to cell cycle progression. PLo. S ONE, Volume 4, p. e 4409. Benade, L. , Howard, T. & Burk, D. , 1969. Synergistic killing of Ehrlich ascites carcinoma cells by ascorbate and 3 -amino-1, 2, 4 -triazole. Oncology, Volume 23, pp. 33 -43. Berlin, S. et al. , 2009. Antiproliferative effect of ascorbic acid is associated with inhibition of genes necessary for cell cycle progression. PLo. S ONE, Volume 4, pp. E 44 -0. Block, K. et al. , 2008. Impact of antioxidant supplementaion on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials. Int J Cancer, Volume 123, pp. 1227 -39. Cameron, E. & Pauling, L. , 1976. Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer. PNAS USA, Volume 73, pp. 3685 -9. Cameron, E. , Pauling, L. & Leibovitz, B. , 1979. Ascorbic acid and cancer, a review. Cancer Res, Volume 39, pp. 663 -81. Campbell, A. & Jack, T. , 1979. Acute reactions to mega ascorbic acid therapy in malignant disease. Scott Med J, Volume 24, p. 151. Campbell, G. , Steinberg, M. & Bower, J. , 1975. Letter: ascorbic acid induced hemolysis in a G-6 -PD deficiency. . Ann Intern Med, Volume 82, p. 810. Casciari, J. , Riordan, H. , Miranda-Massari, J. & Gonzalez, M. , 2005. Effects of high dose of ascorbate administration on L-10 tumor growth in guinea pigs. PRHSJ, Volume 24, pp. 145 -50. Casciari, J. , Riordan, N. S. T. M. X. , Jackson, J. & Riordan, H. , 2001. Cytotoxicity of ascorbate, lipoic acid, and other antioxidants in hollow fibre in vitro tumours. Br. J. Cancer, Volume 84, pp. 1544 -50. Chen, Q. et al. , 2008. Pharmaologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. PNAS USA, Volume 105, pp. 11105 -9. Chen, Q. et al. , 2005. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. PNAS USA, Volume 205, pp. 13604 -13609. Creagan, E. et al. , 1979. Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer: A controlled trial. NEJM, Volume 301, pp. 687 -690. Drisko, J. , Chapman, J. & Hunter, V. , 2003. The use of antioxidants with first-line chemotherapy in two cases of ovarian cancer. Am J Coll Nutr, Volume 22, pp. 118 -23. Du, J. et al. , 2010. Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer. Clin Cancer Res, Volume 16, pp. 509 -20. Espey, M. et al. , 2011. Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer. Free Radic Biol Med, Volume 50, pp. 1610 -19. Espey, M. , Chen, Q. & Levine, M. , 2009. Comment re: vitamin C antagonizes the cytotoxic effects of chemotherapy. Cancer Research , Volume 69, p. 8830. Frei, B. & Lawson, S. , 2008. Vitamin C and cancer revisited. PNAC USA, Volume 105, pp. 11037 -8. Fromberg, A. et al. , 2011. Ascorbate exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells toward cytostatic drugs. . Cancer Chemother Pharmacol, Volume 67, pp. 1157 -66. Fujita, K. et al. , 1982. Reduction of adriamycin toxicity by ascorbate in mice and guinea pigs. Cancer Res, Volume 309 -16, p. 42. Geeraert, L. , 2012. CAM-Cancer Consortium. Intravenous high-dose vitamin C. [Online] Available at: http: //www. cam-cancer. ort/CAM-Summaries/Other-CAM/Intravenous-high-dose-vitamin-C. Ginter, E. , Bobeck, P. & Vargova, D. , 1979. Tissue levels and optimal dosage of vitamin C in guinea pigs. . Nutr Metab, Volume 27, pp. 217 -26. Gonzalez, M. et al. , 2002. Inhibition of human breast cancer carcinoma cell proliferation by ascorbate and copper. . PRHSJ, Volume 21, pp. 21 -3. Heaney, M. et al. , 2008. Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs. Cancer Res. , Volume 68, pp. 8031 -8. Henson, D. , Block, G. & Levine, M. , 1991. Ascorbic acid: biological functions and relation to cancer. JNCI, Volume 83, pp. 547 -50. Hoffer, L. et al. , 208. Phase I clinical trial of i. v. ascorbic acid in advanced malignancy. Ann Oncol, Volume 1969 -74, p. 19. Hoffman, F. , 1985. Micronutrient requirements of cancer patients. . Cancer, 55(Supl. 1), pp. 145 -50. Hornig, D. , 1975. Distribution of ascorbic acid metabolites and analogues in man and animals. Ann NY Acad Sci, Volume 258, pp. 103 -18. Jackson, J. & Hunninghake, R. , 2006. False positive blood glucose readings after high-dose intravenous vitamin C. J Ortho Med, Volume 21, pp. 188 -90. Jackson, J. , Riordan, H. , Hunninghauke, R. & Riordan, N. , 1995. High dose intravenous vitamin C and long time survival of a patient with cancer of the head and pancreas. J Ortho Med, Volume 10, pp. 87 -8. Keith, M. & Pelletier, O. , 1974. Ascorbic acid concentrations in leukocytes and selected organs of guinea pigs in response to increasing ascorbic acid intake. Am J Clin Nutr, Volume 27, pp. 368 -72. Kuether, C. , Telford, I. & Roe, J. , 1988. The relation of the blood level of ascorbic acid to tissue concentrations of this vitamin and the histology of the incisor teeth in the guinea pig. J Nutrition, Volume 28, pp. 347 -58. Kurbacher, C. et al. , 1996. Ascorbic acid (vitamin C) improves the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro. Cancer Lett, Volume 103, pp. 183 -9. Levine, M. et al. , 1996. Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. PNAS USA, Volume 93, pp. 3704 -9. Lin, A. , Chen, K. , Chung, H. & Chang, S. , 2010. The significance of plasma c-reactive protein in patients with elevated serum prostate-specific antigen levels. Urological Sci, Volume 21, pp. 88 -92. • • • • • • • • • Mayland, C. , Bennett, M. & Allan, K. , 2005. Vitamin C deficiency in cancer patients. Palliat Med, Volume 19, pp. 17 -20. Mc. Cormick, W. , 1959. Cancer: a collagen disease, secondary to nutrition deficiency. Arch. Pediatr. , Volume 76, pp. 166 -171. Mikirova, N. , Casciari, J. & Riordan, N. , 2012. Ascorbate inhibition of angiogenesis in aortic rings ex vivo and subcutaneous Matrigel plugs in vivo. J Angiogenesis Res, Volume 2, pp. 2 -6. Mikirova, N. , Casciari, J. , Taylor, P. & Rogers, A. , 2012. Effect of high-dose intravenous vitamin C on inflammation in cancer patients. J Trans Med, Volume 10, pp. 189 -99. Mikirova, N. , Ichim, T. & Riordan, N. , 2008. Anti-angiogenic effect of high doses of ascorbic acid. . J Transl Med, Volume 6, p. 50. Mikirova, N. , Rogers, A. , Casciari, J. & Taylor, P. , 2012. Effects of high dose intravenous ascorbic acid on the level of inflammation in patients with rheumatoid arthritis. Mod Res Inflamm, Volume 1, pp. 26 -32. Moertel, C. et al. , 1985. High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have no prior chemotherapy: a randomized double-blind comparison. . NEJM, Volume 312, pp. 137 -41. Monti, D. et al. , 2012. Phase I evaluation of intravenous ascorbic acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. PLo. S One, Volume 7, p. e 29794. Murata, A. , Morishige, F. & Yamaguchi, H. , 1982. Prolongation of survival times of terminal cancer patients by administration of large doses of ascorbate. Int J Vitam Res Suppl, Volume 23, pp. 103 -13. Okunieff, P. & Suit, H. , 1987. Toxicity, radiation sensitivity modification, and combined drug effects of ascorbic acid with misonidazole in vivo on FSa. II murine firbosarcomas. JNCI, Volume 79, pp. 377 -81. Padayatti, S. et al. , 2006. Intravenous vitamin C as a cancer therapy: three cases. CMAJ, Volume 174, pp. 937 -42. Padayatty, S. & Levine, M. , 2000. Reevaluation of ascorbate in cancer treatment: emerging evidence, open minds and serendipity. J Am Coll Nutr. , Volume 19, pp. 423 -5. Padayatty, S. et al. , 2010. Vitamin C: intravenous use by complementary and alternative medical practitioners and adverse effects. PLo. S ONE, Volume 5, p. 11414. Padayatty, S. et al. , 2004. Vitamin C pharmacokinetics: implications for oral and intravenous use. Ann. Intern. Med. , Volume 140, pp. 533 -37. Page, E. et al. , 2007. Hypoxia incudible factor-1 (alpha) stabilization in nonhypoxic conditions: role of oxidation and intracellualr ascorbate depletion. Mol Biol Cell, Volume 19, pp. 86 -94. Pollard, H. , Levine, M. , Eidelman, O. & Pollard, M. , 2010. Pharmacological ascorbic acid supresses syngenic tumor growth and metastases in hormone-refractory prostate cancer. In VIvo, Volume 2012, pp. 249 -55. Raloff, J. , 2000. Antioxidants may help cancers thrive. Science News, Volume 157, p. 5. Riordan, H. et al. , 2005. A pilot clinical study of continuous intravenous ascorbate in terminal cancer patients. PR Health Sci J, Volume 24, pp. 269 -76. Riordan, H. et al. , 2003. Intravenous ascorbic acid: protocol for its application and use. PR Health Sci. J. , Volume 22, pp. 225 -32. Riordan, H. , Jackson, J. , Riordan, N. & Schultz, M. , 1998. High-dose intravenous vitamin C in the treatment of a patient with renal cell carcinoma of the kidney. J Ortho Med, Volume 13, pp. 72 -3. Riordan, N. , JA, J. & Riordan, H. , 1996. Intravenous vitamin C in a terminal cancer patient. J Ortho Med, Volume 11, pp. 80 -2. Riordan, N. , Roirdan, H. & Meng, X. , 1995. Intravenous ascorbate as a tumor cytotoxic chemotherapeutic agent. Med Hypotheses, Volume 44, pp. 207 -13. Rivers, J. , 1987. Safety of high-level vitamin C ingestion. In: Third Conference on Ascorbic Acid. Ann NY Acad Sci, Volume 489, pp. 95 -102. Shinozaki, K. et al. , 2011. Ascorbic acid enhances radiation-induced apoptosis in an HL 60 human leukemia cell line. J Ratiat Res, Volume 52, pp. 229 -37. Simone, C. , Simone, N. S. V. & CB, S. , 2007. Antioxidants and other nutrients do not inferfere with chemotherapy or radiation therapy and can increase survival, part 1. Atlern Ther Health Med, Volume 13, pp. 22 -8. St. Sauver, J. et al. , 2009. Associations betweeen c-reactive protein and benigh prosaic hyperplasia lower urinary tract outcomes in a population based cohort. Am J Epidemiol, Volume 169, pp. 1281 -90. Taper, H. , Keyeux, A. & Roberfroid, M. , 1996. Potentiation of radiotherapy by nontoxic pretreatment with combined vitamins C and K 3 in mice bearing solid transplantable tumor. Anticancer Res, Volume 16, pp. 499 -503. Verrax, J. et al. , 2004. Ascorbate potentiates the cytotoxicity of menadione leading to an oxidative stress that kills cancer cells by a non-apoptotic capsase-3 independent form of cell death. Apoptosis, Volume 9, pp. 223 -33. Verrax, J. & Calderon, P. , 2009. Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects. Free Radic Biol Med, Volume 47, pp. 32 -40. Vollbracht, C. et al. , 2011. Intravenous vitamin C administration improves quality of life in breast cacner patients during chemo-radiotherapy and aftercare: results of a retrospective, multicentre, epidemiological cohort study in Germany. In Vivo, Volume 82, pp. 983 -90. Wong, K. et al. , 1994. Acute oxalate nephropathy after a massive intravenous dose of vitamin C. Aust ZN J Med, Volume 24, pp. 410 -1. Yeom, C. , Jung, G. & Song, K. , 2007. Changes of terminal cancer patietns health related qualtiy of life after high dose vitamin C administration. Korean Med Sci, Volume 22, pp. 7 -11. Yeom, C. et al. , 2009. High-dose concentration administration of ascorbic acid inhibits tumor growth in BALB/C mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis. J Transl Med, Volume 7, p. 70.

De mest vanlige IV Cocktails • Meyer’s/Myers’ Cocktail o Mineral og vitamin blanding brukt for ME, tretthet, fibromyalgi, depresjon, muskel spasmer, astma, allergier/utslett, CHF/hjertesvikt (veldig sakte drypp!), angina, infeksjoner, og demens. Brukt for å forhindre forkjølelse og influensa, styrke immunforsvaret og øke energi. • Liver Detoxification – o glutathione, alpha lipoic acid, hepar compositum and high dose vitamin C • Dr. Gallagher’s Cocktail – o Øke energi, forbedre enzym funksjoner og nerve funksjoner o vitamin c, glutathione, glyoxal compositum • Heart Health o magnesium, sporstoffer, cerecomp, vitaminer • Migraine o magnesium, riboflavin – kan gis som et push • Hangover Recovery Accelerator o Saline (0. 9% Na. Cl), B vitaminer, vitamin C and glutathione.

Myers’ Cocktail • Utviklet av John Myers, MD • Begynte i 1954 • John Hopkins sykehus, Maryland • Alan Gaby, MD, treated thousands of patients with the Myers’ Cocktail over many years

Fibromyalgi – smerte behandling • 2 cc Mg. SO 4 50% IV pushes: o Føles som om man blir fryktelig varm og tisser på seg …. o Traumeel – homeopatisk traume medisin i sterile ampuller o Methyl kobalamin – hjelper ofte på energien

Enzymer og HCl Betaine • Wobenzyme (4 -8 tab x 3 -4/d akutt) o Betennelse og smerter, ledd problemer o Tysk produsert • Serrapeptase o Betennelse, smerter, etter kirurgi/traumer, blodpropper • Nattokinase o Blodpropper (bryter ned fibrinogen), CVD, kronisk bihulebetennelse, øker HDL • Super oxide dismutase (SOD) o Autoimmun reaksjoner PMID: 29896077 o Alzheimers, Parkinson • Diamine Oxidase (DAO) o Histamin intolerance (HIT) syndromet Fordøyelsen: • HCl Betaine (400 -800 mg/tab) o Din dose? Øk med 1 til brenning i magen o Først beskytt slimhinnen i magesekken • Lipase o For bruk av fordøyelse av fett /GB problematikk • Pepsin, trypsin, amylase, cellulase, protease, sukralase, laktase. …. . o Super Digest. Away – inneholder glutamin o Superzym • DPP IV o Bryter ned gluten og kasein o DPP IV inhibitors/Gliptins: DM 2

1. . Kilder "The story behind Wobenzym". Wobenzym. com. Retrieved 2016 -04 -12. "Science". Wobenzym. com. Retrieved 2016 -04 -12 Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990; 18: 379 -88. . View abstract. Nakamura S, Hashimoto Y, Mikami M, et al. Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease. Respirology 2003; 8: 316 -20. . View abstract. Shimizu H, Ueda M, Takai T, et al. A case of serratiopeptidase-induced subepidermal bullous dermatosis. J Int Med Res 1990; 18: 379 -88. . View abstract. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in postantrotomy buccal swelling. Pharmatherapeutica 1984; 3: 526 -30. . View abstract. https: //www. sciencedirect. com/topics/neuroscience/superoxide-dismutase Allergol Int. October 2017; 66 (4), 594 -602 Doctor Murray 2018 Integr Blood Press Control. 2016 October 13; 9: 95– 104 Int J Mol Sci. Acta Haematol. 1990; 84(3): 139 -43 Biol Pharm Bull 1995 September; 18(9): 1194 -6 Life Extension December 2016 Life Sci. 2003 July 25; 73(10): 1289 -98 Nutr Res. 2009 March; 29(3): 190 -6 Angiology. 2003 September-October; 54(5): 531 -9 Experimentia. 1987 October 15; 43(10): 1110 -1 Bioski Biotechnol Biochem. 2013; 77(2): 392 -4 Smart Publications Nattokinase — The Natural Blood Thinner The Baseline of Health Foundation 1999 -2017 Hum Exp Toxicol. 2013 July; 32(7): 721 -35

Kjertelmedisin • Aktive ingredienser: o Hormoner, enzymer • Næringsrik o Vitaminer, mineraler, aminosyrer, fettsyrer, DNA/RNA, polypeptider…. . • Adaptogenisk effekt o Polypeptider påvirker hormoner o PMID: 22347152 • Sparer egne kjertler o (Hans Selye) • • 1925 textbook Medical Glandular Therapy was published as a joint project between the American Medical Association and the University of Chicago Glandular Physiology and Therapy: Prepared Under the Auspices of the Council on Pharmacy and Chemistry of the American Medical Association o Astwood, E B et al 1955

Stoffskifte - kjertelmedisin Blod test: f. T 3, f. T 4, TSH, anti TPO, anti TG, r. T 3 • Armour • Erfa • Naturethroid • Westhroid • WP Thyroid • Thyrolar • Compounded thyroid: o Apoteket lager blanding av T 2, T 3 og T 4 spesifisert til pasientens behov

Binyre kjertelmedisin Test: Spytte test x 4 + 24 timers urin • • • Adrenal Cortex Adrenal glandulars Adrenal health Adrenavive Adrenal _______

Pankreas/Bukspyttkjertelmedisin • Pankreas o Diabetes – spesielt type 1 o Tidligere histore av pankreatisk sykdommer o Cystisk fibrose o Redusert pankreas funksjon o Kreft

Lever/GB kjertelmedisin • Ox bile (galle fra okse), Lipase o o o De som har fjernet GB Får diare med feit mat Lys avføring Kvalm etter måltider Tørr hud (lite opptak av fett)

Mild depresjon/Lavt stoffskifte/kroniske smerter • Tarmhelse- probiotika!! • Tester for nevrotransmittere i 24 timers urin • Mest vanlig mangler: o Dopamin: lite tiltak/lite energi/sitter fast i sofaen -Tyrosin o Serotonin: gråter mye, trist, søvn - 5 HTP, Inositol o Gamma-aminobutyric acid; uro/angst, søvnforstyrrelser – GABA, Inositol? o Acetylcholine; lærevansker, hukommelse, mentalt trøtt, Alzheimers, demens, Parkinsons PMID: 23202919 • S-Adenosyl L-methionine (SAM-e) o Antidepressive effekt/smertelindring PMID: 28682528

Kilder References 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. Tiwari, Prashant; Dwivedi, Shubhangi; Singh, Mukesh Pratap; Mishra, Rahul; Chandy, Anish (2017 -05 -15). "Basic and modern concepts on cholinergic receptor: A review". Asian Pacific Journal of Tropical Disease. 3 (5): 413– 420. doi: 10. 1016/S 2222 -1808(13)60094 -8. ISSN 2222 -1808. PMC 4027320. Baig AM, Rana Z, Tariq S, Lalani S, Ahmad HR (March 2018). "Traced on the Timeline: Discovery of Acetylcholine and the Components of the Human Cholinergic System in a Primitive Unicellular Eukaryote Acanthamoeba spp". ACS Chem Neurosci. 9 (3): 494– 504. doi: 10. 1021/acschemneuro. 7 b 00254. PMID 29058403. Baig AM, Ahmad HR (June 2017). "Evidence of a M 1 -muscarinic GPCR homolog in unicellular eukaryotes: featuring Acanthamoeba spp bioinformatics 3 D-modelling and experimentations". J. Recept. Signal Transduct. Res. 37 (3): 267– 275. doi: 10. 1080/10799893. 2016. 1217884. PMID 27601178. Smythies J (2009). "Philosophy, perception, and neuroscience". Perception. 38 (5): 638– 51. doi: 10. 1068/p 6025. PMID 19662940. Smythies J, d'Oreye de Lantremange M (2016). "The Nature and Function of Digital Information Compression Mechanisms in the Brain and in Digital Television Technology". Front Syst Neurosci. 10: 40. doi: 10. 3389/fnsys. 2016. 00040. PMC 4858531. PMID 27199688. Miller RD, Eriksson LI, Fleisher LA, Wiener-Kronish JP, Young WL, eds. (2009 -01 -01). Miller's Anesthesia (7 th ed. ). Elsevier Health Sciences. pp. 343– 47. ISBN 0 -443 -06959 -X. Kellogg DL, Zhao JL, Coey U, Green JV (February 2005). "Acetylcholine-induced vasodilation is mediated by nitric oxide and prostaglandins in human skin". J. Appl. Physiol. 98 (2): 629– 32. doi: 10. 1152/japplphysiol. 00728. 2004. PMID 15649880. Jones BE (November 2005). "From waking to sleeping: neuronal and chemical substrates". Trends Pharmacol. Sci. 26 (11): 578– 86. doi: 10. 1016/j. tips. 2005. 09. 009. PMID 16183137. Himmelheber AM, Sarter M, Bruno JP (June 2000). "Increases in cortical acetylcholine release during sustained attention performance in rats". Brain Res Cogn Brain Res. 9 (3): 313– 25. doi: 10. 1016/S 0926 -6410(00)00012 -4. PMID 10808142. Ridley RM, Bowes PM, Baker HF, Crow TJ (1984). "An involvement of acetylcholine in object discrimination learning and memory in the marmoset". Neuropsychologia. 22 (3): 253– 63. doi: 10. 1016/0028 -3932(84)90073 -3. PMID 6431311. Francis PT, Palmer AM, Snape M, Wilcock GK (February 1999). "The cholinergic hypothesis of Alzheimer's disease: a review of progress". J. Neurol. Neurosurg. Psychiatry. 66 (2): 137– 47. doi: 10. 1136/jnnp. 66. 2. 137. PMC 1736202. PMID 10071091. Platt B, Riedel G (August 2011). "The cholinergic system, EEG and sleep". Behav. Brain Res. 221 (2): 499– 504. doi: 10. 1016/j. bbr. 2011. 017. PMID 21238497. Woolf NJ, Butcher LL (May 1986). "Cholinergic systems in the rat brain: III. Projections from the pontomesencephalic tegmentum to the thalamus, tectum, basal ganglia, and basal forebrain". Brain Res. Bull. 16 (5): 603– 37. doi: 10. 1016/0361 -9230(86)90134 -6. PMID 3742247. Woolf NJ, Butcher LL (December 1989). "Cholinergic systems in the rat brain: IV. Descending projections of the pontomesencephalic tegmentum". Brain Res. Bull. 23 (6): 519– 40. doi: 10. 1016/0361 -9230(89)90197 -4. PMID 2611694. Goldberg JA, Reynolds JN (December 2011). "Spontaneous firing and evoked pauses in the tonically active cholinergic interneurons of the striatum". Neuroscience. 198: 27– 43. doi: 10. 1016/j. neuroscience. 2011. 08. 067. PMID 21925242. Morris G, Arkadir D, Nevet A, Vaadia E, Bergman H (July 2004). "Coincident but distinct messages of midbrain dopamine and striatal tonically active neurons". Neuron. 43 (1): 133– 43. doi: 10. 1016/j. neuron. 2004. 06. 012. PMID 15233923. Crow TJ, Grove-White IG (October 1973). "An analysis of the learning deficit following hyoscine administration to man". Br. J. Pharmacol. 49 (2): 322– 7. doi: 10. 1111/j. 1476 -5381. 1973. tb 08379. x. PMC 1776392. PMID 4793334. Ridley RM, Murray TK, Johnson JA, Baker HF (June 1986). "Learning impairment following lesion of the basal nucleus of Meynert in the marmoset: modification by cholinergic drugs". Brain Res. 376 (1): 108– 16. doi: 10. 1016/0006 -8993(86)90904 -2. PMID 3087582. Easton A, Ridley RM, Baker HF, Gaffan D (July 2002). "Unilateral lesions of the cholinergic basal forebrain and fornix in one hemisphere and inferior temporal cortex in the opposite hemisphere produce severe learning impairments in rhesus monkeys". Cereb. Cortex. 12 (7): 729– 36. doi: 10. 1093/cercor/12. 7. 729. PMID 12050084. Dean B (November 2009). "Evolution of the human CNS cholineric system: has this resulted in the emergence of psychiatric disease? ". Aust N Z J Psychiatry. 43 (11): 1016– 28. doi: 10. 3109/00048670903270431. PMID 20001397. • • • References: Alzheimer’s disease medication fact sheet. (n. d. ). National Institute on Aging. Retrieved from http: //www. nia. nih. gov/alzheimers/publication/alzheime rs-disease-medications-fact-sheet American Psychological Association. APA Concise Dictionary of Psychology. Washington, DC: American Psychological Association, 2009. Print. Background to Parkinson’s Disease. (n. d. ). Brown University Division of Biology and Medicine. Retrieved from http: //biomed. brown. edu/Courses/BI 108_1999_Gro ups/Neuroelectrodes_Team/background. html Colman, A. M. (2006). Oxford Dictionary of Psychology. New York, NY: Oxford University Press.

Sex Hormoner

DHEA- dehydroepiandrosterone • Teste binyrebark funksjonen • Overlevelseshormonet • Kvinner: 5 -10 mg o Libido • Menn: 25 -50 mg o Kan øke testosteron (+ Sink og MACA) • 7 -keto DHEA 100 -200 mg o Øker forbrenningen litt – ca 100 kalorier ekstra om dagen o Ingen effekt på sex hormonene (Likevel på WADA listen)

Progesteron • Blod eller spytte test • Skal ha en referanse verdi • Forholdet til østrogen er viktig • I USA solgt som tilskudd fordi de aller fleste er østrogen dominante • Wild Yam

Østrone/Østradiol/Østriol (E 1, E 2, E 3) • • • Test: Blodprøve eller spytteprøve Østrogen må være i balanse med progesteron Må også være i balanse seg i mellom – EQ • Henry Lemon, MD – 40 års forskning på risiko for brystkreft Jonathan Wright, MD, Seattle o Bio Identical hormone specialist • • o Kan være med på å balanser autoimmun reaksjoner Reduser østrogen med: o DIM, I 3 C, Linfrø/Fiber…. . o calcium-D-glucarate, milk thistle, choline, and taurine….

Behandlingsdoser av tilskudd tilgjengelig i Norge • Vitamin C: Daglig 1 -3 gram o Ved forkjølelse/influensa: • 3 gram hver 3. time til tarm toleranse • Vitamin D: Daglig 2000 -3000 IU o Ved sykdom: 5 -10000 IU hver 3. time o Ved mangler: • 10 000 IU daglig – test etter 1 måned • 50 000 IU IM + 5000 IU daglig – test etter 3 uker • N-acetyl cysteine: o 900 mg hver 3. time forkjølelse/slim til tarm toleranse o 900 mg daglig for KOLS, astma, slim i lunger/tarmer, lever problemer/detox, røykere • Magnesium: Daglig 900 -1200 mg o Ved mangler: • 400 -600 mg hver 3. time til tarm toleranse o Formen på magnesium viktig: • Carbonate, oxid, hydroxid, malate, lactate, citrate, orotate, chelate, bisglycate, taurate o Malate – ME/Fibromyalgi o PMID: 25170357 Til tarm toleranse – TTT: Til du får diare

Noen urter som jeg brukte i USA – restriksjoner på i Norge Ashwaganda/Indisk ginseng Holy Basil (Tulsi)/Hellig basilikum Ammi visnaga (Tannstikke) Raowolfia serpentina /Raovulfia/Indisk slangerot • Hawthorn/Crataegus/Hagtorn • Carditon – Ayush Herbs • • o Blodtrykkssenkende • Boswellia (Indisk frankincense) • Scutalleria lateriflora – Praktskjoldbærer • Thuja occidentalis • Piper methysticum /Kava • Valariana spp. • Eschscholzia californica/Kalifornia valmue/morfin

Takk for oppmerksomheten! • • Oddveig Myhre Tlf: 95 48 02 38 oddveig@velkommentiloss. no Facebook: o Dr. Oddveig Myhre o Optimalhelse Senter Skien – OSS o www. velkommentiloss. no