Thrombomodulin Alfa Chemical formula C 2230 H 3357

Thrombomodulin Alfa Chemical formula: C 2230 -H 3357 -N 633 -O 718 -S 50

Description : Thrombomodulin Alfa is a novel, recombinant and soluble thrombomodulin (ART-123). It is a human protein with both thrombin inhibiting and protein C stimulating activities, for the potential treatment of thromboembolism and blood clotting disorders, such as disseminated intravascular thromboembolism.

Indication : Investigated for use/treatment in blood preservative, blood (blood forming organ disorders, unspecified), sepsis and septicemia, and thrombosis.

Mechanism of action : Thrombomodulin alfa is a soluble form of recombinant human thrombomodulin comprising all extracellular domains of thrombomodulin. Bound to thrombin, Thrombomodulin alfa inhibits procoagulant activity and promotes activation of protein C. Thrombomodulin alfa inhibits thrombin generation by the activation of protein C and the subsequent inactivation of factor Va in the presence of protein S. Thrombomodulin alfa attenuates the extension of the clot by inhibiting further thrombin generation on clots, while other anticoagulants inhibit the initiation of clot formation. A higher concentration of Thrombomodulin alfa is needed to affect clotting time and platelet aggregation than thrombin generation.

Brands : Recomodulin (in Japan only) Manufactures: Asahi Kasei Pharma Corp Description : It is a recombinant thrombomod ulin and was approved in Japan on 25 Jan-2008. Categories : Anticoagulant agent, Antiplatelet agent.

Route of administration : Intravenous administration

References https: //www. drugs. com/international/thrombomodulin-alfa. html http: //www. genome. jp/dbget-bin/www_bget? dr: D 06410 https: //www. pharmacodia. com/web/drug/1_1433. html :