Therapeutic Agents in Phase III Clinical Trials for

Therapeutic Agents in Phase III Clinical Trials for Alzheimer’s (Registration Trials) ALZT-OP 1: Mast cell stabilizer + antiinflammatory AZTherapies ANAVEX 2 -73: Muscarinic agonist and sigma receptor agonist Anavex Life Sciences BAN 2401: antibody binding to large, soluble Aβ protofibrils Eisai CAD-106: amyloid vaccine Novartis CNP 520: BACE inhibitor Novartis COR 388: Peptide hydrolase inhibitors Cortexyme Crenezumab: amyloid antibody Levetiracetam: beta-amyloid production inhibitor Agene. Bio Masitinib (Masivet): tyrosine kinase inhibitor AB Science MB 2 (TRx 0237, Methylene Blue): tau aggregation inhibitor Tau. Rx Therapeutics Ltd Pimavanserin: selective inverse agonist of serotonin 5 -HT 2 A receptor Acadia Pharmaceuticals For related symptoms: AVP-786 (agitation): combination of Deuterated [d 6]-Dextromethorphan Hydrobromide and Quinidine Sulfate Avanir Pharmaceuticals Brexpiprazole (agitation): dopamine D 2 receptor partial agonist Otsuka Pharmaceuticals Pimavanserin (psychosis): selective inverse agonist of serotonin 5 -HT 2 A receptor Acadia Pharmaceuticals Solanezumab: amyloid antibody Eli Lilly Trigriluzole: Pro-drug of riluzole, a glutamate modulator agent Biohaven Pharmaceuticals Hoffmann-La Roche Elenbecestat (E 2609): BACE inhibitor Eisai, Biogen Gantenerumab: amyloid antibody Hoffmann-La Roche As of 04/2019 1

Therapeutic Agents in Phase III Clinical Trials for Alzheimer’s (Academic Trials) Curcumin: nutritional supplement University of Florida Ergothioneine: nutritional supplement National University Hospital, Singapore Gantenerumab: amyloid antibody Washington University School of Medicine, Hoffmann-La Roche Guanfacine: α 2 A receptor agonist Imperial College London Human neural stem cells: pluripotent cell line Second Affiliated Hospital of Soochow University Icosapent Ethyl/ Omega-3 fatty acid: nutritional VA Office of Research and Development; University of Southern California; University Hospital, Toulouse As of 04/2019 JNJ-54861911 (atabecestat): BACE inhibitor Washington University Losartan, Amlodipine & Atorvastatin combination therapy: blood pressure reducers University of Texas Southwestern Medical Center Octohydroaminoacridine Succinate: acetylcholinesterase inhibitor Shanghai Mental Health Center Vitamin D 3: nutritional supplement University Hospital, Tours For related symptoms: Escitalopram (agitation): selective serotonin reuptake inhibitor (SSRI) Johns Hopkins School of Public Health Center for Clinical Trials Methylphenidate: norepinephrine–dopamine reuptake inhibitor (NDRI) (Apathy) Johns Hopkins Bloomberg School of Public Health Mirtazapine (agitation): atypical antidepressant University of Sussex Nabilone/ Dronabinol (agitation): synthetic cannabinoid Sunnybrook Health Sciences Centre Zolpidem (sleep): Short-acting nonbenzodiazepine Brasilia University Hospital Zoplicone (sleep): Nonhypnotic sleep aid Brasilia University Hospital 2