The Uses of Nanosensors From Smart Dust to

The Uses of Nanosensors: From Smart Dust to Nano “Mother Ships” Jack Ealy Workshop La Jolla, CA July 2006 Professor Michael J. Sailor UC San Diego Dept. of Chemistry and Biochemistry msailor@ucsd. edu http: //chem-faculty. ucsd. edu/sailor/

Death on the Danube The Economist, 2/15/00

Environmental sampling Lab Field

Smart Dust Kris Pister, UCB (1996) Available: • wireless radios • data processing • networking protocols

Smart Dust Kris Pister, UCB (1996) Need: • sensors • power sources

Silicon vapor sensors

Making a silicon nanostructure 20 mm Electrochemical machining of nanopores

Silicon nanostructures mimic the Calloodes grayanus beetle shell 2 mm Chitin multilayer

Silicon nanostructures mimic the beetle shell Silicon multilayer

Silicon Microsensors

William R. Freeman, M. D. and Lingyun Cheng, M. D. Jacobs Retina Center UCSD

Mother-Ships for Nanotherapies Porous silicon micro-particle in the eye color changes when particle releases drug

Targeted Nanomachines Diagnostic Targeting Self-Destruct Activation Sensor UCSD Moores Cancer Center NIH nano. TUMOR center Erkki Ruoslahti, Burnham Inst. Sangeeta Bhatia, MIT Michael Sailor, UCSD Therapeutic Ruoslahti, Cancer Cell, 2002

Backup slides

Hazards of nanotechnology Asbestos fibers (Nikon, inc) University of Wisconsin, Madison Asbestos Management Program Heating/Chilling Plant: Furnace/Boiler Abatement (December 1997 January 1998) As with any new technology, reasonable concerns about potential hazards are appropriate.

Hazards of nanotechnology Shvedova, A. A. et al. Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J. Toxicol. Environ. Health A 66, 1909 -1926 (2003). Derfus, A. , Chan, W. & Bhatia, S. N. Probing the Cytotoxicity of Semiconductor Quantum Dots. Nano Lett. (2004). 5 nm Cd. Se (A. Paul Alivisatos, UC Berkeley)

Making a silicon nanostructure 20 mm

Encoded particles self-assemble

Magnetic manipulation of microparticles Nature Mater. 2004, 3, 896 -899.