The Urinary System Mosby items and derived items

Learning Objectives List and describe the functions of the kidneys. Describe the gross and microscopic anatomy of the kidneys. List the main blood vessels associated with the kidneys. Define the terms glomerular filtration, renal threshold, polyuria, polydypsia, urolithiasis, and uremia. Describe the production of urine. Describe the mechanisms that affect urine volume. Describe the structures and functions of the ureters and urinary bladder. Describe the processes involved in micturition. Describe the structure and functions of the urethra. Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

The Urinary System Parts of urinary system: Two kidneys Two ureters Urinary bladder Urethra

Kidney Functions Maintain homeostasis through: Ø Ø Filtration, reabsorption, secretion Fluid balance regulation Acid-base balance regulation Production of hormones Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Kidneys Located in dorsal abdominal area ventral to and on either side of the first few lumbar vertebrae Retroperitoneal to abdominal cavity; between peritoneum and dorsal abdominal muscles In most domestic animals, right kidney is more cranial than the left Thick layer of perirenal fat usually surrounds kidneys to help protect them from pressure exerted by surrounding organs Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Gross Anatomy of Kidneys Fibrous connective tissue capsule Hilus: indented area on medial side of the kidney Ø Ureters, nerves, blood and lymph vessels enter and leave kidney Renal Pelvis: funnel-shaped area inside hilus Forms beginning of the ureter Ø Lined with transitional epithelium Ø Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Gross Anatomy of Kidneys Renal cortex: outer portion of the kidney Renal medulla: inner portion around the renal pelvis Calyx: cuplike extension of the renal pelvis into which the medullary pyramids fit Ø Calyces act as funnels to direct fluid into renal pelvis Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Microscopic Anatomy of Kidneys Nephron: basic functional unit of kidneys Number of nephrons per kidney varies Each nephron consists of a renal corpuscle, proximal convoluted tubule, loop of Henle and distal convoluted tubule Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Renal Corpuscle Located in renal cortex Function: filters blood in first stage of urine production Composed of glomerulus surrounded by Bowman’s capsule Ø Glomerulus: “tuft” of capillaries Fluid filtered out of blood is called glomerular filtrate Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Proximal Convoluted Tubule (PCT) Continuation of capsular space of Bowman’s capsule Lined with cuboidal epithelial cells with a brush border on lumen side Twisting path through the cortex Glomerular filtrate now called the tubular filtrate Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Loop of Henle Descends from PCT into medulla, turns, heads upward into cortex Descending loop has epithelial cells similar to those of PCT At bottom of loop, epithelial cells flatten to simple squamous epithelial cells and lose their brush border Ascending loop wall becomes thicker again Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Distal Convoluted Tubule (DCT) Continuation of ascending loop of Henle DCT from all nephrons in the kidney empty into collecting ducts Carry tubular filtrate through medulla Ø Empty into renal pelvis Ø Primary site of action of ADH and regulation of potassium and acidbase balance Ø Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Blood Supply Renal artery enters the kidney at the hilus Ø Divides into smaller

Blood Supply Afferent glomerular arterioles carry blood into the glomerular capillaries of renal corpuscle Glomerular capillaries filter some of the plasma out of blood and put it in the capsular space of Bowman’s capsule Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Blood Supply Efferent glomerular arterioles receive blood form glomerular capillaries Mosby items and derived

Blood Supply Efferent glomerular arterioles divide to form the peritubular capillaries Surrounds the rest of the nephron Ø Oxygen transfer to the cells of the nephron takes place here Ø Tubular reabsorption and secretion also occurs here Ø Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Blood Supply Peritubular capillaries converge to form venules, then larger veins, and finally the renal vein. The renal vein leaves the kidney at the hilus and joins the abdominal portion of the caudal vena cava. Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Filtration of Blood Glomerular capillaries contain many large fenestrations in capillary endothelium Ø Fenestrations not large enough to allow blood cells or large proteins to pass through High blood pressure in the glomerular capillaries forces some plasma out of the capillaries and into the capsular space of Bowman’s capsule Glomerular filtration rate (GFR): how fast plasma is filtered through glomerulus Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Reabsorption Substances to be reabsorbed pass out of the tubular lumen through or between tubular epithelial cells Substances to be reabsorbed then enter interstitial fluid and pass through endothelium into peritubular capillaries Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Sodium Reabsorption Sodium in tubular filtrate attaches to carrier protein that moves it into the cytoplasm of the PCT epithelial cell Ø Glucose and amino acids attach to same carrier protein and follow sodium into the cell by passive transport (sodium cotransport) Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Sodium Reabsorption Sodium is actively pumped out of cell into interstitial fluid, where it moves into peritubular capillaries Ø Glucose and amino acids move from the PCT cell into interstitial fluid and then into the peritubular capillaries by passive diffusion Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Reabsorption Sodium ions are also reabsorbed in ascending loop of Henle and DCT Ø Potassium and calcium reabsorption take place in the PCT, ascending loop of Henle and DCT Ø Usually exchanged for hydrogen, ammonium, or potassium ions Calcium moves from the filtrate under the influence of Vitamin D, parathyroid hormone (PTH), and calcitonin Magnesium is reabsorbed from the PCT, ascending loop of Henle, and the collecting duct Ø PTH release increases the reabsorption of magnesium Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Reabsorption Chloride (Cl–) diffuses from tubular filtrate into the epithelial cells and interstitial space in response to electrical imbalance created by (Na+) removal Some of the water in the filtrate moves into the interstitial space and peritubular capillaries by osmosis once sodium, glucose, amino acids, and chloride have left the tubular filtrate Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Secretion Primarily occurs in the DCT Hydrogen, potassium, and ammonia are eliminated by secretion Some medications are also eliminated from the body by secretion Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Urine Volume Regulation Determined by amount of water contained in the tubular filtrate when it reaches renal pelvis Controlled by actions of ADH and aldosterone ADH acts on the DCT and collecting ducts to promote water reabsorption Aldosterone increases reabsorption of sodium Ø Causes osmotic imbalance that encourages water to follow sodium out of the tubular filtrate and into blood Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Ureters Leave kidney at the hilus Outer fibrous layer, middle smooth muscle layer, and inner layer lined with transitional epithelium Transitional epithelium allows ureters to stretch as urine passes through them on its way to urinary bladder Ø Smooth muscle layer propels urine through ureter by peristaltic contractions Ø Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Ureters enter urinary bladder at an oblique angle When the bladder is full, it collapses the opening of the ureter, preventing urine from backing up into ureter Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Urinary Bladder Lined with transitional epithelium that stretches as the bladder becomes filled with urine Wall of the urinary bladder contains smooth muscle bundles Neck of the bladder extends caudally from the sac into the pelvic canal and joins the urethra Around the neck of the urinary bladder are circular muscles composed of skeletal muscle fibers Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Control of Urination Micturition or uresis: expulsion of urine from the urinary bladder into the urethra Urine accumulates until pressure of the filling bladder activates stretch receptors in bladder wall Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Control of Urination A spinal reflex returns a motor impulse to bladder muscles causing them to contract Ø Contraction gives the sensation of having to urinate Voluntary control of the muscular sphincter around the neck of the bladder results in temporary control of urination Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Urethra Continuation of the neck of the urinary bladder Carries urine from the urinary bladder to the external environment Lined with transitional epithelium which allows it to expand Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.

Urethra The female urethra is shorter and straighter than the long, curved male urethra. In the female the urethra opens on the ventral portion of the vestibule of the vulva. Ø In the male the urethra runs down the center of the penis and also functions in the reproductive system. Ø Mosby items and derived items © 2008 by Mosby, Inc. , an affiliate of Elsevier Inc.