The sorafenib plus nutlin3 combination promotes synergistic cytotoxicity

The sorafenib plus nutlin-3 combination promotes synergistic cytotoxicity in acute myeloid leukemic cells irrespectively of FLT 3 and p 53 status by Giorgio Zauli, Claudio Celeghini, Elisabetta Melloni, Rebecca Voltan, Manuele Ongari, Mario Tiribelli, Maria Grazia di Iasio, Francesco Lanza, and Paola Secchiero haematol Volume 97(11): 1722 -1730 November 2, 2012 © 2012 by Ferrata Storti Foundation

Synergistic cytotoxicity by the sorafenib+nutlin-3 combination in myeloid leukemic cell lines. Giorgio Zauli et al. Haematologica 2012; 97: 1722 -1730 © 2012 by Ferrata Storti Foundation

Sorafenib+nutlin-3 promote both apoptosis and autophagy in myeloid leukemic cells. Giorgio Zauli et al. Haematologica 2012; 97: 1722 -1730 © 2012 by Ferrata Storti Foundation

Sorafenib+nutlin-3 synergistically promote apoptosis and autophagy in both p 53 wild-type and p 53 deleted leukemic cells. p 53 wild-type (OCI) and p 53 deleted (HL 60) leukemic cells were exposed for 24 h to nutlin-3 and sorafenib used either alone or in combinatio. . . Giorgio Zauli et al. Haematologica 2012; 97: 1722 -1730 © 2012 by Ferrata Storti Foundation

Role of Bax in mediating the anti-leukemic activity of sorafenib+nutlin-3 in p 53 wild-type leukemic cells. Giorgio Zauli et al. Haematologica 2012; 97: 1722 -1730 © 2012 by Ferrata Storti Foundation

Role of Bak in mediating the anti-leukemic activity of sorafenib+nutlin-3 in p 53 deleted leukemic cells. Giorgio Zauli et al. Haematologica 2012; 97: 1722 -1730 © 2012 by Ferrata Storti Foundation